SYRE
Spyre Therapeutics Inc.NASDAQ
Healthcare • Biotechnology
Factor tilt: Mid-Cap Momentum
$103.86+7.53%
Close Nov 6, 2026
- Market cap
- $8.8B
- 1 month
- +30.0%
- 3 months
- -1.4%
- 1 year
- +354.5%
- 52-week range
- $22.18$108.92
- Dividend
- No dividends on record
- Next-quarter EPS estimate
- -$0.84Quarter to Sep 30, 2026 · 13 analysts · -2.0% in 30d
- Short interest
- 15.2% of float12.5M shares · settled Oct 15, 2026 · -2.6% since Sep 30, 2026 · FINRA
Fundamentals · trailing 12 months to Jun 30, 2026
- Revenue
- $90.49M
- Net income
- -$178.92M
- Free cash flow
- -$208.94M
- Book value
- $1.1B
- Total debt
- —
- P/E
- —
- Price / sales
- 97.2×
- Price / book
- 8×
- FCF yield
- -2.4%
- Net margin
- -197.7%
EODHD (TTM) · as of Nov 6, 2026
End-of-day close from stored market data, not a live quote.
About Spyre Therapeutics Inc.
Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases.
Read more
The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 " anti-TL1A mAbs designed to bind to tumor necrosis factor-like ligand 1A (TL1A). It is also developing SPY003, a clinical-stage program, which is in phase-2 clinical stage designed to bind to interleukin 23 (IL-23); SPY120, a combination of anti-a4ß7 and anti-TL1A mAbs; SPY130, a combination anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. The company was incorporated in 2013 and is based in Waltham, Massachusetts.
- Website
- spyre.com
- Headquarters
- Waltham, MA, United States
- Employees
- 125
- Listed
- Apr 7, 2016
- Fiscal year ends
- December
Company profile from EODHD, stored Nov 5, 2026.
Quarterly results
The last 8 fiscal quarters as reported (EODHD). Year over year compares the same quarter a year earlier.
| Quarter | Revenue | YoY | Gross margin | Op. income | Net income |
|---|---|---|---|---|---|
| Jun 2026filed Aug 4, 2026 | — | — | — | -$41.6M | -$36.2M |
| Mar 2026filed May 5, 2026 | — | — | — | -$45.6M | -$69.0M |
| Dec 2025filed Feb 19, 2026 | $90.5M | — | 50.0% | -$57.2M | -$62.5M |
| Sep 2025filed Nov 4, 2025 | — | — | — | -$56.9M | -$11.2M |
| Jun 2025filed Aug 5, 2025 | — | — | — | -$41.9M | -$36.7M |
| Mar 2025filed May 8, 2025 | — | — | — | -$53.6M | -$44.8M |
| Dec 2024filed Feb 27, 2025 | — | — | — | -$61.3M | -$56.3M |
| Sep 2024filed Nov 18, 2024 | — | — | — | -$55.4M | -$69.0M |
Fiscal years · last 6
| Fiscal year | Revenue | YoY | Gross margin | Op. income | Net income |
|---|---|---|---|---|---|
| Dec 2025filed Feb 19, 2026 | — | — | — | -$209.6M | -$155.2M |
| Dec 2024filed Feb 27, 2025 | $886.0K | 0.0% | — | -$208.6M | -$208.0M |
| Dec 2023filed Feb 29, 2024 | $886.0K | -62.0% | -8.8% | -$242.3M | -$338.8M |
| Dec 2022filed Dec 31, 2022 | $2.3M | — | — | -$84.8M | -$83.8M |
| Dec 2021filed Dec 31, 2021 | — | — | — | — | — |
| Dec 2020filed Dec 31, 2020 | — | — | — | -$81.5M | -$80.9M |
Short-interest history
FINRA reports open short positions for a settlement date. The publication date is later. These are reported positions, with a separate date for each observation.
Compare the reported short exposure around the dates you bought, sold or watched SYRE. A long position benefits from price rises; a short position benefits from falls. A change in these counts does not predict either move.
Settlement Oct 15, 2026
12,505,491 shares short
-339,117 shares (-2.6%) vs Sep 30, 2026
15.2% of the stored float. Published Oct 26, 2026.
Settlement Sep 30, 2026
12,844,608 shares short
+715,165 shares (+5.9%) vs Sep 15, 2026
15.6% of the stored float. Published Oct 9, 2026.
Settlement Sep 15, 2026
12,129,443 shares short
+269,468 shares (+2.3%) vs Aug 31, 2026
15% of the stored float. Published Sep 24, 2026.
Settlement Aug 31, 2026
11,859,975 shares short
+104,541 shares (+0.9%) vs Aug 14, 2026
14.7% of the stored float. Published Sep 10, 2026.
Settlement Aug 14, 2026
11,755,434 shares short
-388,445 shares (-3.2%) vs Jul 31, 2026
14.5% of the stored float. Published Aug 25, 2026.
Settlement Jul 31, 2026
12,143,879 shares short
-364,831 shares (-2.9%) vs Jul 15, 2026
15% of the stored float. Published Aug 11, 2026.
Change = this settlement’s shares short − the previous recorded settlement’s shares short; percentage change divides by that earlier count. A zero earlier count has no percentage change. Split-spanning counts are left uncompared. Float percentages use the stored settlement observation, not today’s float.
Source: stored FINRA equity short-interest records, up to six settlements from the last 240 days. FINRA data and reporting dates · How to read short interest
Dividends and stock splits
See the recorded cash amounts and dates behind SYRE’s income, and the splits that change its share count. Dates below are stored event records, not confirmation of a payment to your account.
Cash-dividend records
No qualified cash-dividend records are stored. This does not establish that the company pays no dividend.
Up to six Polygon cash-dividend events, including recorded ex-dates within the next 120 days. Amounts retain their recorded currency and decimal precision. Historical amounts are not restated to a common split basis, annualized, or converted to dollars.
For a long holding, compare the ex-date with when you held the shares and check the pay date against your broker’s cash history. Owning the stock today does not establish past entitlement. For a short holding, a dividend can create a payment obligation to the share lender.
Ex-dates and special dividend rules · Short-sale dividend obligations · Dividend data definitions
Split history
1 for 25 · reverse split
Effective Sep 8, 2023
Each 25 pre-split shares become 1 post-split share.
Source: EODHD
Up to six stored split dates through Nov 7, 2026. Equivalent vendor ratios are combined; conflicting ratios are left out. This history may be incomplete.
A split changes the share count and per-share price basis; it does not by itself add investment value. Put your holding’s earlier and later share counts on the same basis before comparing them. This applies to both long shares and shares owed on a short position.
How stock splits workPortfolio context
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Smart money context
Holder IQ: MEDIUM
60 smart-money holders: institutions with a high Holder IQ
Q2 2026, filed Oct 27, 2026
Smart-money 13F trend: distributing (light)
Unlock crowding heatmapUnlock filer discoveryInsider context
Sentiment: bearish
Last trade: sell 36 days ago
Read the insider context evidence
What it means for you
Sign in to read your holdings or watchlist context. No personal position or direction is inferred.
What happened
Stored recent-activity label: bearish. This context label is separate from the scored insider signal read.
Why it can matter
A count of reported activity describes a sample, not purchase conviction, an insider’s intent or a future price move. Neutral is not an all-clear, and absent direction is not neutral evidence.
How we got this
The current context rule reads at most 50 nonduplicate issuer/share-class records filed in the last 90 days. It counts a bullish direction or purchase code P toward bullish, and a bearish direction or sale code S toward bearish. A side must exceed the opposite count by more than two to set its label; otherwise nonzero directional counts produce neutral. Calculation unavailable for this saved label: its counts, exact records, as-of time and rule version are not supplied here. Do not substitute the separate scored read’s different window or denominator.
Where the data comes from
Stored SEC Forms 3/4/5 insider-signal records, ordered by filing date with amendment duplicates excluded. Filing date is not transaction date. The last-trade line locates recent reported activity; it does not date or reconstruct the complete count.
Red flags: 0
Read the insider context evidence
What it means for you
Sign in to read your holdings or watchlist context. No personal position or direction is inferred.
What happened
Stored recent-activity label: bearish. This context label is separate from the scored insider signal read.
Why it can matter
A count of reported activity describes a sample, not purchase conviction, an insider’s intent or a future price move. Neutral is not an all-clear, and absent direction is not neutral evidence.
How we got this
The current context rule reads at most 50 nonduplicate issuer/share-class records filed in the last 90 days. It counts a bullish direction or purchase code P toward bullish, and a bearish direction or sale code S toward bearish. A side must exceed the opposite count by more than two to set its label; otherwise nonzero directional counts produce neutral. Calculation unavailable for this saved label: its counts, exact records, as-of time and rule version are not supplied here. Do not substitute the separate scored read’s different window or denominator.
Where the data comes from
Stored SEC Forms 3/4/5 insider-signal records, ordered by filing date with amendment duplicates excluded. Filing date is not transaction date. The last-trade line locates recent reported activity; it does not date or reconstruct the complete count.
Largest 13-F holders · Q2 2026
267 filers reported a long position in SYRE for Q2 2026. 13-F holdings are filed up to 45 days after the quarter ends.
The top 10 hold
49.2%
of the 95.8M shares 13-F filers reported
Moves vs Q1 2026
9 added1 trimmed
Net shares held
+15.2%
across the 10 holders with a comparable Q1 2026 book
| Rank | Holder | Value | Shares | Shares vs Q1 2026 |
|---|---|---|---|---|
| 1 | FMR LLC | $1.2B · 13M shares | 13M | +10.6% |
| 2 | BlackRock, Inc. | $577.7M · 6.5M shares | 6.5M | +17.8% |
| 3 | PERCEPTIVE ADVISORS LLC | $383.5M · 4.3M shares | 4.3M | +14.2% |
| 4 | RTW INVESTMENTS, LP | $377.5M · 4.3M shares | 4.3M | +1.9% |
| 5 | Paradigm Biocapital Advisors LP | $341M · 3.8M shares | 3.8M | +96.2% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | $306.2M · 3.4M shares | 3.4M | +12.8% |
| 7 | STATE STREET CORP | $271.4M · 3.1M shares | 3.1M | +17.3% |
| 8 | Venrock Adviser, LLC | $265M · 3M shares | 3M | -19% |
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | $262.9M · 3M shares | 3M | +85.2% |
| 10 | DRIEHAUS CAPITAL MANAGEMENT LLC | $248.5M · 2.8M shares | 2.8M | +0.3% |
Sign in to see each holder’s Holder IQ, factor-adjusted Holder IQ and rank, and compare these holders with all scored filers. Available on every plan.
Sign in5% holder filings (13D / 13G)
Holders of more than 5% of SYRE file with the SEC within days. A 13D holder may seek to influence the company; a 13G holder is passive. Each holder’s latest filing from the last three years.
| Filed | Holder | % of class |
|---|---|---|
| Oct 9, 2026 | Fairmount Funds Management LLC13D · activist · amended | 9.99% |
| Oct 1, 2026 | Paradigm Biocapital Advisors LP13G · passive | 5.1% |
| Aug 14, 2026 | RTW INVESTMENTS, LP13G · passive · amended | 4.8%under 5% |
| Aug 14, 2026 | PERCEPTIVE ADVISORS LLC13G · passive · amended | 4.9%under 5% |
| Mar 27, 2026 | VANGUARD GROUP INC13G · passive · amended | 0%under 5% |
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