SPTX
Seaport Therapeutics, Inc. Common StockNASDAQ
Healthcare • Biotechnology
$21.50+5.44%
Close Nov 6, 2026
- Market cap
- $1.15B
- 1 month
- +20.0%
- 3 months
- -6.6%
- 1 year
- —
- Dividend
- No dividends on record
- Short interest
- 20.2% of float3.7M shares · settled Oct 15, 2026 · +1.9% since Sep 30, 2026 · FINRA
Fundamentals · trailing 12 months to Sep 30, 2026
- Revenue
- —
- Net income
- —
- Free cash flow
- —
- Book value
- $397.46M
- Total debt
- $4.69M
- P/E
- —
- Price / sales
- —
- Price / book
- 2.9×
- FCF yield
- —
- Net margin
- —
EODHD (TTM) · as of Nov 6, 2026
End-of-day close from stored market data, not a live quote.
About Seaport Therapeutics, Inc. Common Stock
Seaport Therapeutics, Inc., a clinical-stage therapeutics company, focuses on inventing and developing new medicines for patients with depression, anxiety, and other debilitating neuropsychiatric disorders. It is leveraging its proprietary Glyph platform to advance a pipeline of therapies to address the unmet needs in depression and anxiety.
Read more
The company's lead product candidate, GlyphAllo (SPT-300 or Glyph Allopregnanolone), is a novel, Glyphed oral prodrug of allopregnanolone, an endogenous molecule that has been clinically validated in third-party trials for the treatment of postpartum depression. Its second product candidate, GlyphAgo (SPT-320 or Glyph Agomelatine), is a novel, Glyphed oral prodrug of agomelatine, a clinically validated anxiolytic and antidepressant that is approved for the treatment of generalized anxiety disorder in Australia and major depressive disorder in Australia and the European Union. The company was founded in 2024 and is based in Boston, Massachusetts.
- Website
- seaporttx.com
- Headquarters
- Boston, MA, United States
- Employees
- 58
- Listed
- May 1, 2026
- Fiscal year ends
- December
Company profile from EODHD, stored Nov 4, 2026.
Quarterly results
The last 4 fiscal quarters as reported (EODHD). Year over year compares the same quarter a year earlier.
| Quarter | Revenue | YoY | Gross margin | Op. income | Net income |
|---|---|---|---|---|---|
| Sep 2026filed Nov 2, 2026 | — | — | — | -$30.3M | -$26.4M |
| Jun 2026filed Aug 3, 2026 | — | — | — | -$65.8M | -$62.6M |
| Mar 2026filed Mar 31, 2026 | — | — | — | -$27.5M | -$25.4M |
| Mar 2025 | — | — | — | -$16.2M | -$13.1M |
Fiscal years · last 1
| Fiscal year | Revenue | YoY | Gross margin | Op. income | Net income |
|---|---|---|---|---|---|
| Dec 2025filed Dec 31, 2025 | — | — | — | -$87.3M | -$74.9M |
Short-interest history
FINRA reports open short positions for a settlement date. The publication date is later. These are reported positions, with a separate date for each observation.
Compare the reported short exposure around the dates you bought, sold or watched SPTX. A long position benefits from price rises; a short position benefits from falls. A change in these counts does not predict either move.
Settlement Oct 15, 2026
3,718,915 shares short
+69,036 shares (+1.9%) vs Sep 30, 2026
20.2% of the stored float. Published Oct 26, 2026.
Settlement Sep 30, 2026
3,649,879 shares short
+500,998 shares (+15.9%) vs Sep 15, 2026
19.8% of the stored float. Published Oct 9, 2026.
Settlement Sep 15, 2026
3,148,881 shares short
-3,528 shares (-0.1%) vs Aug 31, 2026
11.1% of the stored float. Published Sep 24, 2026.
Settlement Aug 31, 2026
3,152,409 shares short
+139,532 shares (+4.6%) vs Aug 14, 2026
11.1% of the stored float. Published Sep 10, 2026.
Settlement Aug 14, 2026
3,012,877 shares short
+254,848 shares (+9.2%) vs Jul 31, 2026
Share of float unavailable. Published Aug 25, 2026.
Settlement Jul 31, 2026
2,758,029 shares short
+777,753 shares (+39.3%) vs Jul 15, 2026
Share of float unavailable. Published Aug 11, 2026.
Change = this settlement’s shares short − the previous recorded settlement’s shares short; percentage change divides by that earlier count. A zero earlier count has no percentage change. Split-spanning counts are left uncompared. Float percentages use the stored settlement observation, not today’s float.
Source: stored FINRA equity short-interest records, up to six settlements from the last 240 days. FINRA data and reporting dates · How to read short interest
Dividends and stock splits
See the recorded cash amounts and dates behind SPTX’s income, and the splits that change its share count. Dates below are stored event records, not confirmation of a payment to your account.
Cash-dividend records
No qualified cash-dividend records are stored. This does not establish that the company pays no dividend.
Up to six Polygon cash-dividend events, including recorded ex-dates within the next 120 days. Amounts retain their recorded currency and decimal precision. Historical amounts are not restated to a common split basis, annualized, or converted to dollars.
For a long holding, compare the ex-date with when you held the shares and check the pay date against your broker’s cash history. Owning the stock today does not establish past entitlement. For a short holding, a dividend can create a payment obligation to the share lender.
Ex-dates and special dividend rules · Short-sale dividend obligations · Dividend data definitions
Split history
No qualified split events are stored. This does not establish that the stock has never split.
Up to six stored split dates through Nov 7, 2026. Equivalent vendor ratios are combined; conflicting ratios are left out. This history may be incomplete.
A split changes the share count and per-share price basis; it does not by itself add investment value. Put your holding’s earlier and later share counts on the same basis before comparing them. This applies to both long shares and shares owed on a short position.
How stock splits workPortfolio context
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Smart money context
Holder IQ: MEDIUM
15 smart-money holders: institutions with a high Holder IQ
Q2 2026, filed Sep 22, 2026
Insider context
Sentiment: neutral
Last trade: buy 3 days ago
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What it means for you
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What happened
Stored recent-activity label: neutral. This context label is separate from the scored insider signal read.
Why it can matter
A count of reported activity describes a sample, not purchase conviction, an insider’s intent or a future price move. Neutral is not an all-clear, and absent direction is not neutral evidence.
How we got this
The current context rule reads at most 50 nonduplicate issuer/share-class records filed in the last 90 days. It counts a bullish direction or purchase code P toward bullish, and a bearish direction or sale code S toward bearish. A side must exceed the opposite count by more than two to set its label; otherwise nonzero directional counts produce neutral. Calculation unavailable for this saved label: its counts, exact records, as-of time and rule version are not supplied here. Do not substitute the separate scored read’s different window or denominator.
Where the data comes from
Stored SEC Forms 3/4/5 insider-signal records, ordered by filing date with amendment duplicates excluded. Filing date is not transaction date. The last-trade line locates recent reported activity; it does not date or reconstruct the complete count.
Red flags: 0
Read the insider context evidence
What it means for you
Sign in to read your holdings or watchlist context. No personal position or direction is inferred.
What happened
Stored recent-activity label: neutral. This context label is separate from the scored insider signal read.
Why it can matter
A count of reported activity describes a sample, not purchase conviction, an insider’s intent or a future price move. Neutral is not an all-clear, and absent direction is not neutral evidence.
How we got this
The current context rule reads at most 50 nonduplicate issuer/share-class records filed in the last 90 days. It counts a bullish direction or purchase code P toward bullish, and a bearish direction or sale code S toward bearish. A side must exceed the opposite count by more than two to set its label; otherwise nonzero directional counts produce neutral. Calculation unavailable for this saved label: its counts, exact records, as-of time and rule version are not supplied here. Do not substitute the separate scored read’s different window or denominator.
Where the data comes from
Stored SEC Forms 3/4/5 insider-signal records, ordered by filing date with amendment duplicates excluded. Filing date is not transaction date. The last-trade line locates recent reported activity; it does not date or reconstruct the complete count.
Largest 13-F holders · Q2 2026
55 filers reported a long position in SPTX for Q2 2026. 13-F holdings are filed up to 45 days after the quarter ends.
The top 10 hold
75.4%
of the 37.5M shares 13-F filers reported
Moves vs Q1 2026
No comparable changes
10 new
| Rank | Holder | Value | Shares | Shares vs Q1 2026 |
|---|---|---|---|---|
| 1 | ARCH Venture Management, LLC | $136.6M · 6.3M shares | 6.3M | New |
| 2 | GENERAL ATLANTIC, L.P. | $132.5M · 6.1M shares | 6.1M | New |
| 3 | Sofinnova Investments, Inc. | $77.4M · 3.6M shares | 3.6M | New |
| 4 | GOLDMAN SACHS GROUP INC | $47.3M · 2.2M shares | 2.2M | New |
| 5 | TRV GP VI, LLC | $44.8M · 2.1M shares | 2.1M | New |
| 6 | CANADA PENSION PLAN INVESTMENT BOARD | $42.9M · 2M shares | 2M | New |
| 7 | JPMORGAN CHASE & CO | $40.9M · 1.8M shares | 1.8M | New |
| 8 | Foresite Capital Management VI LLC | $38.7M · 1.8M shares | 1.8M | New |
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | $28.4M · 1.3M shares | 1.3M | New |
| 10 | FMR LLC | $25.7M · 1.2M shares | 1.2M | New |
Sign in to see each holder’s Holder IQ, factor-adjusted Holder IQ and rank, and compare these holders with all scored filers. Available on every plan.
Sign in5% holder filings (13D / 13G)
Holders of more than 5% of SPTX file with the SEC within days. A 13D holder may seek to influence the company; a 13G holder is passive. Each holder’s latest filing from the last three years.
| Filed | Holder | % of class |
|---|---|---|
| Aug 14, 2026 | PureTech LYT, Inc.13G · passive | 31.2% |
| Aug 5, 2026 | Zohar Daphne13G · passive | 9.1% |
| Aug 5, 2026 | PAUL STEVEN M13G · passive | 6.3% |
| May 11, 2026 | GENERAL ATLANTIC, L.P.13D · activist | 11.5% |
| May 11, 2026 | GOLDMAN SACHS GROUP INC13G · passive | 5.5% |
| May 6, 2026 | ARCH Venture Fund XII LP13D · activist | 11.9% |
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