Matinas BioPharma Holdings Inc

This proxy statement contains information related to the Annual Meeting of Stockholders to be held on June 23, 2025 at 9 a.m. local time via the internet at www.virtualshareholdermeeting.com/MTNB2025, or at such other time and place to which the Annual Meeting may be adjourned or postponed. The enclosed proxy is solicited by the Board of Directors of Matinas BioPharma Holdings, Inc. (the “Board”). The proxy materials relating to the Annual Meeting are being mailed to stockholders entitled to vote at the meeting on or about May 12, 2025.

Important Notice of Availability of Proxy Materials for the Annual Meeting of Stockholders to be held on June 23, 2025.

Our proxy materials, including our Proxy Statement for the 2025 Annual Meeting, our Annual Report for the fiscal year ended December 31, 2024, and proxy card are available on the Internet at www.proxyvote.com.