ICON PLC

Cautionary Statement Regarding Forward-Looking Statements

Statements included herein which are not historical facts are forward-looking statements. Such forward-looking statements are made

pursuant to the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Examples of forward-looking

statements include, but are not limited to, statements regarding the following: anticipated financial results for 2026, 2027 and beyond;

contracted revenue; the Company's expectations regarding business momentum, market opportunity, demand trends, growth, and

commercial performance; and the Company's expectations with respect to its long-term value creation and competitive positioning. You

can identify many forward-looking statements by words such as “aims,” “anticipates,” “believes,” “continues,” “could,” “estimates,”

“expects,” “focused,” “guidance,” “intends,” “look,” “may,” “opportunities,” “plans,” “positions,” “potential,” “predicts,” “projects,” “seeks,”

“should,” “will,” “would” and other similar expressions and the negatives of such expressions. However, not all forward-looking statements

contain these words. These statements are based on management's current expectations and information currently available, including

current economic and industry conditions. The forward-looking statements involve a number of risks and uncertainties and are subject to

change at any time. In the event such risks or uncertainties materialize, our results could be materially adversely affected. The risks and

uncertainties include, but are not limited to, dependence on the pharmaceutical industry and certain clients, the need to regularly win

projects and then to execute them efficiently and correctly, the challenges presented by rapid growth, competition and the continuing

consolidation of the industry, the impact of market conditions on demand for the Company's services, risks related to the Company's

ability to execute on its commercial strategy and maintain relationships with large pharmaceutical customers, and risks relating to the

Company's strategic partnerships, the dependence on certain key executives, changes in the regulatory environment, exchange rate

fluctuations, inflation and rising labor costs. Please also refer to the section entitled "Risk Factors" of our Annual Report on Form 20-F for

the year ended December 31, 2025 filed on May 27, 2026 for a discussion of some of the principal risks that could adversely affect our

business, operations and financial results. The Company’s forward-looking statements speak only as of the date of this report or as of the

date they are made, and the Company undertakes no obligation to update its forward-looking statements.