Cibus, Inc.

Priority Pipeline Traits and Programs

•Weed Management (HT1 and HT3) in Rice

◦Cibus continues to make significant progress with its Rice herbicide tolerance traits, which represent the Company's priority pipeline program. Trait editing and introgression, field trials, and registration of traits remain on track for targeted initial commercial launches in Latin America in 2027-2028, followed by targeted expansion into the U.S. in 2028 and India/Asia (excluding China) in 2030.

◦To date, Cibus has signed seven Rice customer agreements. Together, the Company estimates that these seven customers represent approximately 5-7 million addressable acres (i.e., acres that would be potentially accessible to Cibus’ HT1 and HT3 traits in Rice) and, if fully developed, over $200 million in potential annual royalty opportunity.

◦In October, Cibus entered an agreement engaging AgVayā to develop a comprehensive strategy to support Cibus’ entry into India (the world’s second-largest producer and the largest exporter of rice, with approximately 125 million acres under cultivation). The engagement focuses on enabling joint development and commercialization relationships for advanced herbicide resistant and sustainability traits, creating opportunities for Indian Rice seed companies and public agencies to integrate cutting-edge gene editing solutions.

◦In August, signed a material transfer agreement with CIAT, which works with the Latin American Fund for Irrigated Rice (FLAR) and participates in the Hybrid Rice Consortium for Latin America (HIAAL). Through this agreement, Cibus will provide its HT3 clethodim herbicide tolerance trait to be introduced into HIAAL's elite Rice germplasm, representing significant market access in Latin America.

◦In July, signed a material transfer agreement with Colombian Rice producer Semillano.

◦Completed delivery of Rice lines with the HT3 trait to an existing US customer.

◦Following 2024 field trial results for stacked gene edited herbicide tolerance traits in Rice, in March 2025 the Company expanded its efforts to include additional trait stacking to broaden weed management for crop protection with additional field testing underway.

•Partner-Funded and/or Supported Sustainable Ingredients Program

◦Successfully completed pre-commercial pilot runs with its fermentation contractor during Q3 2025.

◦Received initial payment (partially offsetting related R&D expenses) in Q4 2025, marking the Company's first payment from this program and representing an important milestone.

◦Targeting commercial expansion planned in 2026.