TRINITY BIOTECH PLC

(Fourth Amendment)

Sixth Amended and Restated Credit Agreement and Guaranty 1

dated as of

August 7, 2025

among

Trinity Biotech, Inc.,

Clark Laboratories, Inc. (d/b/a Trinity Biotech (USA)),

Biopool U.S., Inc. (d/b/a Trinity Biotech Distribution),

Primus Corporation,

MarDx Diagnostics, Inc. and

IMMCO Diagnostics, Inc.

TRIB Biosensors Inc.

as the Borrowers,

The Guarantors from Time to Time Party hereto,

as Guarantors

and

Perceptive Credit Holdings III, LP,

as Administrative Agent and as a Lender

Conformed to reflect changes from the First Amendment to Sixth Amended and Restated Credit Agreement and Guaranty, dated as of October 16, 2025, the Second Amendment to Sixth Amended and Restated Credit Agreement and Guaranty, dated as of December 22, 2025, the Limited Waiver and Third Amendment to Sixth Amended and Restated Credit Agreement and Guaranty, dated as of April 30, 2026 and the Limited Waiver and Fourth Amendment to Sixth Amended and Restated Credit Agreement and Guaranty, dated as of August 12, 2026.

Table of Contents

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Schedules:

Schedule 1 — Term Loan Commitments

Schedule 2 — Notice Addresses

Schedule 3 — Products

Schedule 4 — Commercial Partners

Schedule 7.01 — Power and Authority

Schedule 7.05(a) — Obligor Owned Real Property

Schedule 7.05(b) — Obligor Material Intellectual Property

Schedule 7.06(a) — Litigation

Schedule 7.13A — Existing Indebtedness

Schedule 7.13B — Existing Liens

Schedule 7.14 — Material Agreements

Schedule 7.15 — Restrictive Agreements

Schedule 7.16 — Real Property

Schedule 7.17 — Pension Matters

Schedule 7.19(b) — Regulatory Approvals

Schedule 7.19(e) — Regulatory Authority Notices

Schedule 7.20 — Capitalization

Schedule 7.22 — Broker’s Fee

Schedule 7.23 — Trade Compliance

Schedule 7.26 — Royalty and Other Payments

Schedule 8.19 — Post Tranche F Term Loan Borrowing Date Obligations

Schedule 9.03 — Subsidiaries to be Dissolved

Schedule 9.05(a) — Existing Investments

Schedule 9.10 — Transactions with Affiliates

Exhibits:

Exhibit A — Form of Guarantee Assumption Agreement

Exhibit B — [Reserved]

Exhibit C — [Reserved]

Exhibit D — Form of U.S. Tax Compliance Certificate

Exhibit E — Form of Compliance Certificate

Exhibit F — Form of Assignment Agreement

Exhibit G-1 — Form of U.S. Security Agreement

Exhibit G-2 — Form of Canadian Security Agreement

Exhibit G-3 — Form of Irish Debenture

Exhibit H-1 — Form of Patent and Trademark Security Agreement

Exhibit H-2 — Form of Copyright Security Agreement

Exhibit I — Form of Collateral Questionnaire

Exhibit J — [Reserved]

Exhibit K — Form of Intercompany Subordination Agreement

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Exhibit L — Form of Investor Subordination Agreement

Exhibit M — Form of Effective Date Term Loan Borrowing Notice

Exhibit N — Form of Delayed Draw Term Loan Borrowing Notice

Exhibit O — Form of Third Amendment Term Loan Borrowing Notice

Exhibit P — Form of Fourth Amendment Term Loan Borrowing Notice

Exhibit Q — Form of Fifth Amendment Term Loan Borrowing Notice

Exhibit R — Form of Sixth Amendment Term Loan Borrowing Notice

Exhibit S — Form of Tranche C Term Loan Borrowing Notice

Exhibit T — Form of Tranche D Term Loan Borrowing Notice

Exhibit U — Form of Tranche E Term Loan Borrowing Notice

Exhibit V — Form of Tranche F Term Loan Borrowing Notice

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Sixth Amended and Restated Credit Agreement And Guaranty, dated as of August 7, 2025 (this“Agreement”), among Trinity Biotech, Inc., a Delaware corporation (“U.S. Holdings”), Clark Laboratories, Inc. (d/b/a Trinity Biotech (USA)), a New York corporation (“U.S. Clark”), Biopool U.S., Inc., a Delaware corporation (d/b/a Trinity Biotech Distribution) (“U.S. Biopool”), Primus Corporation, a Missouri corporation (“U.S. Primus”), MarDx Diagnostics, Inc., a California corporation (“U.S. MarDx”), IMMCO Diagnostics, Inc., a Delaware corporation (“U.S. Immco”), TRIB Biosensors Inc., a Delaware corporation (“U.S. TRIB”, and together with U.S. Holdings, U.S. Clark, U.S. Biopool, U.S. Primus, U.S. MarDx and U.S. Immco, each a “Borrower” and collectively, the“Borrowers”), certain Guarantors from time to time parties hereto, the lenders from time to time party hereto (each, as a “Lender” and collectively, the “Lenders”), and Perceptive Credit Holdings III, LP, a Delaware limited partnership (“Perceptive”), as administrative agent for the Lenders (in such capacity, together with its successors and assigns, the “Administrative Agent”).