ORAGENICS INC

APPENDIX A

PROXY CARD

PROXY

THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

FOR THE 2025 ANNUAL MEETING OF SHAREHOLDERS

TO BE HELD ON JUNE 29, 2026, AT 10:00 a.m.

The undersigned shareholder of Oragenics, Inc. (the “Company”) hereby appoints Janet Huffman with full power of substitution, as proxy of the undersigned to vote all shares of common stock of the Company that the undersigned is entitled to vote at the Annual Meeting of Shareholders of the Company to be held virtually on June 29, 2026 at 10:00 a.m. and all adjournments or postponements thereof, and to otherwise represent the undersigned at the Annual Meeting with all the powers possessed by the undersigned if personally present at the meeting. The undersigned revokes any proxy previously given to vote at such meeting. The undersigned hereby instructs said proxies or their substitutes to vote as specified on the reverse side of this card on each of the matters specified and in accordance with their judgment on any other matters which may properly come before the meeting or any adjournment or postponement thereof. In order to attend the meeting, you must register athttps://web.viewproxy.com/oragenics/2025 by 11:59 p.m. EDT on June 28, 2026. On the day of the Annual Meeting of Shareholders, if you have properly registered, you may enter the meeting by clicking on the link you received via email in your registration confirmations. Further instructions on how to attend and vote at the Annual Meeting of Shareholders are contained in the Proxy Statement.

▼PLEASE DETACH ALONG PERFORATED LINE AND MAIL IN THE ENVELOPE PROVIDED. ▼

This proxy, when properly executed, will be voted as directed. IF NO DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED FOR THE NOMINEES IN PROPOSAL 1, FOR PROPOSAL 2, FOR PROPOSAL 3 AND FOR PROPOSAL 4. ****

Signature

Date

Title

Signature (Joint Owners)

NOTE: Please sign exactly as name(s) appear(s) hereon. When signing as attorney, executor, administrator or other fiduciary, please give full title as such. Joint owners should each sign personally. If a corporation, limited liability company or partnership, please sign in full corporate, limited liability company, or partnership name by authorized officer or person.

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Important Notice Regarding the Availability of Proxy Materials for the

2025 Annual Meeting of Shareholders to be held on June 29, 2026:

The 2025 Proxy Statement and 2025 Annual Report are available at

https://web.viewproxy.com/oragenics/2025

When properly executed, your proxy card/voting instruction form will be voted in the manner you direct. If you do not specify your choices, your shares will be voted along with the Board’s recommendations.

The Board of Directors recommends you vote FOR each of the nominees in Proposal 1:

Please mark your votes like this ☒

Proposal 1. Elections of Directors:

The Board of Directors recommends you vote FOR Proposals 2, 3 and 4.

Proposal 2. Advisory vote on executive compensation.

Proposal 3. Approval of Reverse Stock Split Proposal.

Proposal 4. Ratification of the selection of Cherry Bekaert LLP as the Company’s independent auditors for the year ending December 31, 2026.

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