TALPHERA INC

2024 Annual Meeting of Stockholders

Our Board of Directors has established June 24, 2024 as the date of our 2024 Annual Meeting of Stockholders, or the 2024 Annual Meeting, as previously announced on the Current Report on Form 8-K filed with the SEC on April 19, 2024. The time and location of the 2024 Annual Meeting are as set forth in our definitive proxy statement for the 2024 Annual Meeting filed with the SEC on April 29, 2024.

Stockholders who intended to present proposals for inclusion in the proxy materials for the 2024 Annual Meeting pursuant to Rule 14a-8 promulgated under the Exchange Act, must ensure that such proposals were received by us, in writing, at 1850 Gateway Drive, Suite 175, San Mateo, California 94404, and were directed to the attention of the Corporate Secretary, no later than April 23, 2024, which we determined to be a reasonable time before we expect to begin to deliver and make available our proxy materials, and must have furthermore complied with all applicable requirements of Rule 14a-8.

Pursuant to our Amended and Restated Bylaws, to be considered timely, stockholders who intended to present proposals for director nominations or any other proposal at the 2024 Annual Meeting must have provided notice in writing to us at 1850 Gateway Drive, Suite 175, San Mateo, California 94404, and have directed such notice to the attention of the Corporate Secretary, no later than the close of business on April 29, 2024, the tenth calendar day following the date of Current Report on Form 8-K filed with the SEC on April 19, 2024, publicly announcing the date of the 2024 Annual Meeting.