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CervoMed Inc

Filed May 10, 2024.

View on SEC.gov

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A company's registration of shares for sale to the public, often for a first offering. It describes the business, its risks and how the company plans to use the money.

period unavailable · Filed May 10, 2024

CRVO$1.42-2.1%Stored close · as of Nov 6, 2026
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Contents

INTRODUCTORY NOTES

Note Regarding Company References and Other Defined Terms

As previously disclosed in our Current Report on Form 8-K filed on August 17, 2023 with the SEC, on August 16, 2023, the Delaware corporation formerly known as “Diffusion Pharmaceuticals Inc.” completed a merger transaction in accordance with the terms and conditions of the Agreement and Plan of Merger, dated March 30, 2023 (the “Merger Agreement”) by and among Diffusion Pharmaceuticals Inc. (“Diffusion”), Dawn Merger Inc., a wholly-owned subsidiary of Diffusion (“Merger Sub”) and EIP Pharma, Inc. (“EIP”), pursuant to which Merger Sub merged with and into EIP, with EIP surviving the Merger a wholly-owned subsidiary of Diffusion (the “Merger”). Additionally, on August 16, 2023, Diffusion changed its name from “Diffusion Pharmaceuticals Inc.” to “CervoMed Inc.”

Prior to the Effective Time (as defined below), in connection with the transactions contemplated by the Merger Agreement, Diffusion effected a reverse stock split of the Company’s common stock, par value $0.001 per share (“Common Stock” or “common stock”), at a ratio of 1-for-1.5 (the “Reverse Stock Split”). At the Effective Time, each outstanding share of EIP capital stock was converted into the right to receive 0.1151 shares of Company common stock.

For accounting purposes, the Merger is treated as a reverse recapitalization under US GAAP and EIP is considered the accounting acquirer. Accordingly, EIP’s historical results of operations are deemed the Company’s historical results of operations for all periods prior to the Merger and, for all periods following the Merger, the results of operations of the combined company will be included in the Company’s consolidated financial statements. Following the completion of the Merger, the business conducted by the Company became primarily the business conducted by EIP.

Accordingly, unless the context otherwise requires, all references in this prospectus to (i) “CervoMed,” the “Company,” “we,” “our,” or “us,” refer to the business of EIP for all dates and periods prior to August 16, 2023 and to the business of CervoMed for all dates and periods subsequent to (and including) August 16, 2023 and (ii) “common stock” refer to the common stock, par value $0.001 per share, of the Company, after giving effect to the Reverse Stock Split. Historical share and per share figures of EIP have been retroactively restated based upon the exchange ratio of 0.1151.

We have also used several other defined terms in this prospectus, many of which are explained or defined below:

TermDefinition
2015 Equity PlanCervoMed Inc. 2015 Equity Incentive Plan, as amended
2018 Equity PlanCervoMed Inc. 2018 Employee, Director and Consultant Equity Incentive Plan, as amended
2020 Notesthe previously outstanding convertible promissory notes of EIP, dated as of December 4, 2020, as amended
2021 Notesthe previously outstanding convertible promissory notes of EIP, dated as of December 10, 2021, as amended
2022 Sales Agreementour At-The-Market Sales Agreement, dated July 22, 2022, with BTIG, as agent
2024 Private Placementour private placement of an aggregate of 2,532,285 units, each consisting of (i) (A) one share of common stock or (B) one Pre-Funded Warrant in lieu thereof and (ii) one Series A Warrant, for aggregate gross proceeds of up to approximately $149.4 million, completed on April 1, 2024
401(k) PlanCervoMed Inc. 401(k) Defined Contribution Plan
ADAlzheimer’s Disease
ACAAffordable Care Act and the Healthcare and Education Reconciliation Act
ACR20American College of Rheumatology 20
AIAAmerica Invents Act
AKSanti-kickback statute
Alpine RewardsAlpine Rewards LLC, outside independent consultant to the Compensation Committee
ANDAabbreviated new drug application
ASCAccounting Standard Codification of the FASB
AscenD-LB Trialour Phase 2a clinical trial evaluating neflamapimod for the treatment of patients with DLB, completed in the second half of 2021
Audit Committeethe Audit Committee of the Board
Bayh-Doyle ActBayh-Dole Act of 1980
BIDtwice daily
BFCbasal forebrain cholinergic
BTIGBTIG LLC
Boardthe board of directors of the Company
Boger Trustthe Joshua S. Boger 2021 Trust DTD 12/09/2021
Bylawsthe Bylaws, as amended, of the Company
CARES ActCoronavirus Aid, Relief, and Economic Security Act
CCPAthe California Consumer Privacy Act
CPRAthe California Privacy Rights Act
CDR-SBClinical Dementia Rating Sum of Boxes test
CGICthe Alzheimer’s Disease Cooperative Study-Clinician Global Impression of Change
cGMPcurrent good manufacturing practices
ChAT+ neuronsneurons staining positively for choline acetyl transferase
CMCchemistry, manufacturing and controls
CMOcontract manufacturing organization
CMSthe U.S. Centers for Medicare & Medicaid Services
Compensation Committeethe Compensation Committee of the Board
Convertible Notescollectively, the 2020 Notes and the 2021 Notes
CNScentral nervous system
Codethe U.S. Internal Revenue Code of 1986, as amended
CREATES Actthe Creating and Restoring Equal Access to Equivalent Samples Act of 2019
CRLComplete Response Letter
CROcontract research organization
CSFcerebrospinal fluid
DGCLDelaware General Corporation Law
DGMdeep grey matter
Diffusion Registration StatementAmendment No. 2 to our Registration Statement on Form S-4, filed with the SEC on July 11, 2023, as amended from time to time
DLBdementia with Lewy bodies
DNPthe FDA’s Division of Neurology Products
DSCSADrug Supply Chain Security Act
EEAEuropean Economic Area
EEGelectroencephalogram
Effective Timethe effective time of the Merger on August 16, 2023
EIP Common Stockthe common stock, par value $0.001, of EIP issued and outstanding prior to the Merger
EIP Convertible Notescollectively, the 2020 Notes and the 2021 Notes
EMAEuropean Medicines Agency
EOADEarly Onset Alzheimer’s Disease
EOTend of treatment
Exchange ActSecurities Exchange Act of 1934, as amended
Exchange Ratiothe “Exchange Ratio” as defined in the Merger Agreement
FASBFinancial Accounting Standards Board
FCPAthe Foreign Corrupt Practices Act
FDAU.S. Food and Drug Administration
FDCAFederal Food, Drug, and Cosmetic Act
FDICFederal Deposit Insurance Corporation
FTCFederal Trade Commission
FTDfrontotemporal dementia
GBMglioblastoma multiforme brain cancer
GCPgood clinical practice
GDPREuropean Union General Data Protection Regulation
GLPgood laboratory practice
HIPAAthe Health Insurance Portability and Accountability of Act of 1996
HVLTHopkins Verbal Learning Test
IMMirreversible morbidity and mortality
INDinvestigational new drug application
IRAInflation Reduction Act of 2022
IRBinstitutional review board
ITinformation technology
MAmarketing authorization
MCImild cognitive impairment
MRImagnetic resonance imaging
MSNmedial septal nucleus
NasdaqNasdaq Stock Market, LLC
NbMNucleus basalis of Meynert
NCEnew chemical entity
NDAnew drug application
NEOnamed executive officer, as defined in Rule 402(m) of Regulation S-K
NGFnerve growth factor
NIAthe National Institute on Aging of the National Institutes of Health
NIA Grantthe $21 million grant awarded to us by the NIA in January 2023 to support the RewinD-LB Trial
NIHNational Institutes of Health
NOLnet operating loss
NTBNeuropsychological Test Battery
NYSENew York Stock Exchange
p38αp38 mitogen-activated protein kinase alpha
PBMpharmacy benefit manger
PDParkinson’s disease
PDABprescription drug affordability board
PDDParkinson’s disease dementia
PDMAPrescription Drug Marketing Act
PDUFAPrescription Drug User Fee Act, as amended
PETpositron emission tomography
POCproof-of-concept
PPAprimary progressive aphasia
Pre-Funded Warrantsthe pre-funded warrants each to purchase one share of common stock at a purchase price of $0.001 per share issued in connection with the 2024 Private Placement
PREAPediatric Research Equity Act
ptau181plasma phosphorylated tau at position 181
RArheumatoid arthritis
R&Dresearch and development
Regulation S-KRegulation S-K promulgated under the Securities Act
REMSRisk Evaluation and Mitigation Strategy
RewinD-LB Trialour Phase 2b clinical trial evaluating neflamapimod for the treatment of patients with DLB, initiated in the second quarter of 2023
RLDreference-listed drug
SABscientific advisory board
SAEserious adverse events
SECU.S. Securities and Exchange Commission
Section 382Section 382 of the Code
Securities ActSecurities Act of 1933, as amended
Series A Warrantsthe warrants to purchase an aggregate of 2,532,285 shares of common stock at a purchase price of $39.24 per share issued in connection with the 2024 Private Placement
TCJATax Cuts and Jobs Act of 2017
TIDthree times daily
TSCtrans sodium crocetinate
TUGTimed Up and Go test
UPLupper payment limit
U.S.United States of America
US GAAPU.S. generally accepted accounting principles
USPTOU.S. Patent and Trademark Office
VertexVertex Pharmaceuticals Incorporated
Vertex Agreementthe Option and License Agreement, dated as of August 27, 2012, by and between EIP Pharma LLC and Vertex, as amended
ContentsView on SEC.gov

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