Silexion Therapeutics Corp

PROPOSAL 2

REVERSE SHARE SPLIT PROPOSAL

Background

Nasdaq Minimum Bid Price Requirement

Our ordinary shares and warrants are listed on the Nasdaq Capital Market under the trading symbols “SLXN” and “SLXNW”, respectively, and we need to ensure that we continue to comply with all quantitative listing standards of the Nasdaq Listing Rules on an ongoing basis. One such listing standard with which we need to ensure our ongoing compliance is the minimum bid price rule. In particular, Nasdaq Listing Rule 5550(a)(2) requires that our ordinary shares maintain a minimum closing bid price of $1.00 per share on an ongoing basis in order to remain listed on the Nasdaq Capital Market (the “Minimum Bid Price Requirement”).

The business combination whereby we became a publicly-traded company with securities listed on Nasdaq was completed on August 15, 2024. Since that time, the closing price for our ordinary shares has traded at a range of prices.

We have failed to comply with the Minimum Bid Price Requirement and have received a listing deficiency notice on September 25, 2026, due to our closing bid price having been below $1.00 for 30 consecutive business days, and we have requested, at a Nasdaq hearings panel held on September 24, 2026, a compliance period, until late November 2026, to regain compliance with that requirement. If this Proposal 2 is approved, the Board, acting pursuant to the approval by our shareholders at the Meeting, will effect a reverse share split of all issued and outstanding, and all authorized, ordinary shares. In the aftermath of, and as a result of, that reverse share split, the trading price of our ordinary shares is expected to rise, and in late November 2026, we expect to receive a follow-up letter from Nasdaq notifying us that we have regained compliance with the Minimum Bid Price Requirement.

We have similarly effected 1-for-9, 1-for-15 and 1-for-10 reverse share splits of all of our issued and outstanding, and authorized but unissued, ordinary shares on November 27, 2024, July 28, 2025 and May 28, 2026, respectively, in order to prevent or remedy prior minimum bid price deficiencies under the Nasdaq Listing Rules.

If the Nasdaq hearings panel does not accept our request to be given time to remedy our current deficiency in meeting the Minimum Bid Price Requirement, and our ordinary shares are delisted from Nasdaq, such a delisting would be likely to adversely affect our company and the holders of our ordinary shares in many ways, as detailed below in this Proposal 2 and in the “Risk Factors Related to the Proposals— Risk Factors Related to Reverse Share Split” section of this proxy statement below.

The market price of our ordinary shares reflects a variety of factors, most importantly, the progress of, and prospects related to, the development of our product candidates, as well as additional factors such as our financial condition, market conditions for biotechnology companies generally, and conditions related to our location in Israel. Even if we continue to report positive results and progress towards the development of our product candidates, we may nevertheless not see an improvement in our share price, since many of the factors impacting that price are beyond our control.

Rationale for Increasing/Maintaining Market Price

Besides enabling us to avoid the delisting of the ordinary shares from Nasdaq and accompanying adverse consequences, our maintenance of a share price that is comfortably above the $1.00 minimum bid price level is furthermore a key strategic interest of ours, as it will assist us in raising capital to continue to support our clinical trials. We are advancing our Phase 2/3 clinical trials seeking statistically significant results with respect to our SIL204 product candidate in locally advanced pancreatic cancer subjects in Israel and Germany, and we expect our expenses to increase substantially in connection with our ongoing activities, particularly as we advance our product candidates through clinical studies. If we are unable to attract desirable investors that provide financing on a timely basis, we may be required to significantly curtail, delay, or discontinue one or more of our research, development or manufacturing programs or the commercialization of any product candidates, or be unable to expand our operations or otherwise capitalize on our business opportunities, as desired, which could materially adversely affect our business, financial condition, and results of operations.

To date, we have financed our operations primarily through the sale of equity securities, including public offerings of ordinary shares, pre-funded warrants and ordinary warrants completed in January 2025, September 2025 and August 2026, sales of ordinary shares into the public market under the ATM Agreement, and induced warrant exercise transactions completed in January 2025, August 2025, May 2026 and September 2026. Many potential desirable investors or financing sources may be unwilling to consider an investment in our company on reasonable terms or at all if our share price remains at or below the minimum $1.00 price level under the Nasdaq Listing Rules, in part due to a fear that our ordinary shares and warrants may be delisted from Nasdaq, which would likely reduce liquidity and increase volatility in our trading price.

In order to raise the market price of our ordinary shares should it remain below $1.00 per share, and thereby remedy the violation of Nasdaq’s Minimum Bid Price Requirement and accompanying delisting proceedings, we are proposing that our shareholders approve, at the meeting, a reverse share split at a set ratio, which will be between 1-for-15 and 1-for-25, inclusive. A reverse share split should have the immediate impact of boosting the bid price per share by a proportionate ratio, due to the deemed relatively higher value attributable to each ordinary share following such a reverse split. The actual ratio within the above-described range will be presented to our shareholders for approval at the meeting.

Impact of Reverse Share Split on Our Ordinary Shares

One principal effect of the reverse share split under any ratio at which it would be effected would be to decrease the number of our issued and outstanding ordinary shares. Except forde minimus adjustments that may result from the treatment of fractional shares as described below, however, the reverse split will not have any dilutive effect on our shareholders since each shareholder would hold the same percentage of our ordinary shares outstanding immediately following the reverse split as such shareholder held immediately prior to the reverse split. Therefore, voting and other rights that accompany the ordinary shares would not be affected by the reverse split.

In addition, the proportion of shares owned by our shareholders relative to the number of shares authorized for issuance will remain the same (disregarding the effect of the Authorized Share Capital Increase Proposal, which would be implemented prior to the reverse share split) because the authorized number of our ordinary shares (including authorized, unissued shares) will be decreased in proportion to the ratio at which the reverse split will be effected at the effective time of the reverse split, as the case may be. The remaining authorized shares may be used for various purposes, including, without limitation, raising capital, providing equity incentives to employees, officers or directors, and/or establishing strategic relationships with other companies. We currently plan to use the available authorized shares, if increased pursuant to Proposal 1, for financing transactions and/or business development transactions for our company that will help us to maintain compliance with the Nasdaq minimum $2.5 million shareholders’ equity requirement under the Equity Standard of the Nasdaq Capital Market. Beyond the foregoing purposes, we currently do not have any plans, proposals or arrangements to issue any of the available authorized shares for any other purposes.

Implementation of Reverse Share Split

The Board believes that it is in the best interest of the Company and its shareholders and is hereby soliciting shareholder approval to effect a reverse share split of all the Company’s issued and outstanding ordinary shares at a ratio of not less than 1-for-15 and not more than 1-for-25, inclusive. The exact ratio of the reverse split to be presented for approval by our shareholders at the extraordinary general meeting will be determined by our Board prior to the meeting based on market conditions and the market price of the ordinary shares during the period leading up to, and immediately prior to, the meeting. Our board of directors will determine which resolution- containing a specific reverse split ratio- will be presented for approval at the meeting, whereby, assuming shareholder approval of the proposal, on the effective date of the reverse share split, all of the Company’s issued and unissued ordinary shares will be, automatically and without any action on the part of the shareholders, combined, converted and changed into new ordinary shares in accordance with that reverse share split ratio. If the shareholders approve the Reverse Share Split Proposal, the Board will have the authority, but not the obligation, in its sole discretion, and without further action on the part of the shareholders, to effect a reverse share split at the approved ratio any time after the approval of the shareholders.

The Board will only effect a reverse share split pursuant to the Reverse Share Split Proposal, however (assuming that the proposal is approved), if the Board believes that a decrease in the number of ordinary shares outstanding is likely to improve the trading price of our ordinary shares, and to restore compliance with the Minimum Bid Price Requirement, and, furthermore, only if the implementation of a reverse share split is determined by the Board to be in the best interests of the Company and its shareholders.

The Board believes that our solicitation of shareholder approval of a reverse share split ratio within a range in connection with the Reverse Share Split Proposal, which will only be set by the Board immediately prior to the meeting, provides the Board with flexibility to achieve the purposes of any such reverse share split that may be effected. The additional time between the date of this proxy statement and the date of the extraordinary general meeting will enable the Board to analyze market conditions and our share price and determine what ratio within the range described in this Proposal 2 best fulfills the purposes of the reverse share split. The determination will be made by the Board with the intention to create the greatest marketability of the Company’s ordinary shares based upon prevailing market conditions at that time. The Board reserves its right to elect not to proceed, and abandon, the reverse share split if it determines, in its sole discretion, that implementing such reverse share split is not in the best interests of the Company and its shareholders. We currently anticipate, however, that the Board will implement the reverse share split promptly after (and subject to) shareholder approval of Proposal 2 at the meeting (which will be after implementation of an increase to our authorized share capital, which will occur immediately after (and subject to) the approval of Proposal 1 at the meeting).

We cannot assure you that the price per share of our ordinary shares immediately after a reverse share split will increase proportionately to that reverse share split, or that any increase will be sustained for any period of time. We also cannot assure you that an active and liquid public market for our ordinary shares will exist or be maintained post-reverse split. Further, regardless of our compliance with the Minimum Bid Price Requirement, the listing of our shares on the Nasdaq Capital Market may be halted or discontinued if we are unable to maintain compliance with any other Nasdaq continued listing requirement for any reason. Please see the “Risk Factors Related to the Proposals- Risk Factors Related to the Reverse Share Split Proposal” section below.

Fractional Shares

Shareholders would not receive fractional ordinary shares in connection with the reverse share split. In lieu of any fractional shares, we will round up or round down to the nearest whole share the number of ordinary shares issuable to any record shareholder (as well as DTC participants) who would otherwise hold a fractional share divisible by the reverse split ratio. For example, if a record shareholder holds 150.75 ordinary shares following the reverse share split, that shareholder will be issued 151 ordinary shares. No shareholders will receive cash in lieu of fractional shares.

We do not expect the reverse share split and the rounding up or down of fractional shares to whole shares to result in a significant change in the relative percentage ownership of our various shareholders.

Effect on Ordinary Shares, Authorized Ordinary Shares and Par Value

If the reverse share split is approved by our shareholders and our Board implements the reverse share split, then as of the effective time of the reverse share split, all ordinary shares (issued and unissued) will automatically be combined into new ordinary shares in accordance with the reverse share split ratio and our ordinary shares will have a new CUSIP number. Additionally, the number of authorized ordinary shares would be reduced and the par value of all of the ordinary shares would be adjusted upwards in a corresponding manner, each proportionate to the reverse share split ratio. To the extent that Proposal 1 (the Authorized Share Capital Increase Proposal) is approved at the meeting, there will be an increase to the number of authorized, unissued ordinary shares immediately following the meeting prior to the reduction of that number pursuant to the implementation of the reverse share split.

Effect on Outstanding Equity Awards, Warrants, and Equity Plans

If the reverse share split is approved by our shareholders and our Board implements the reverse share split, as of the effective time, proportionate adjustments will be made to (i) the number of ordinary shares that are subject to all then-outstanding equity awards and warrants, such that fewer shares would underlie such awards and warrants, (ii) the exercise price of all then-outstanding options and warrants, such that the per share exercise price of each such option and warrant would be increased, and (iii) the number of ordinary shares available for issuance under our equity incentive plans, such that fewer shares will be subject to such plans.

Illustration

For purposes of illustration, the following table contains current pre-reverse split information and placeholders for post-reverse split information, which will be inserted once the Board determines the proposed reverse share split ratio and the Company confirms the related share information.

Accounting Consequences

The reverse share split will not have an effect on the stated capital attributable to ordinary shares on our balance sheet because the par value of each of the ordinary shares will be increased by the same ratio as the ratio contemplated by the reverse share split. Reported net income or loss per ordinary share and book value per ordinary share will be higher because there will be fewer ordinary shares.

Material U.S. Federal Income Tax Consequences

The following is a summary of the material U.S. federal income tax consequences of the reverse share split to U.S. Holders (as defined below) of our ordinary shares. This summary is based on the Internal Revenue Code of 1986, as amended (the “Code”), the Treasury regulations promulgated thereunder, and administrative rulings and court decisions in effect as of the date of this proxy statement, all of which may be subject to change, possibly with retroactive effect. No assurance can be given that the Internal Revenue Service (the “IRS”) will agree with the consequences described in this summary, or that a court will not sustain any challenge by the IRS in the event of litigation. No advance tax ruling has been or will be sought or obtained from the IRS regarding the tax consequences of the reverse share split.

For purposes of this summary, a “U.S. Holder” is a beneficial owner of our ordinary shares that is (a) an individual who is a citizen of the United States or who is resident in the United States for U.S. federal income tax purposes, (b) an entity that is classified for U.S. federal income tax purposes as a corporation and that is organized under the laws of the United States, any state thereof, or the District of Columbia, or is otherwise treated for U.S. federal income tax purposes as a domestic corporation, (c) an estate the income of which is subject to U.S. federal income taxation regardless of its source, or (d) a trust (i) the administration of which is subject to the primary supervision of a court within the United States and all substantial decisions of which are subject to the control of one or more United States persons as described in Section 7701(a)(30) of the Code (“United States persons”), or (ii) that has a valid election in effect under applicable Treasury regulations to be treated as a United States person.

This summary does not discuss all U.S. federal income tax considerations that may be relevant to U.S. Holders in light of their particular circumstances or that may be relevant to certain beneficial owners that may be subject to special treatment under U.S. federal income tax law (for example, tax-exempt organizations, S corporations, partnership and other pass through entities (and investors therein), mutual funds, insurance companies, banks and other financial institutions, dealers in securities, brokers or traders in securities, commodities or currencies that elect to use a mark-to-market method of accounting, real estate investment trusts, regulated investment companies, individual retirement accounts, qualified pension plans, persons who hold our ordinary shares as part of a straddle, hedging, constructive sale, conversion, or other integrated transaction, U.S. Holders that have a functional currency other than the U.S. dollar, and persons who acquired our ordinary shares as a result of the exercise of employee stock options or otherwise as compensation or through a tax-qualified retirement plan). Furthermore, this summary does not discuss any alternative minimum tax consequences or the Medicare contribution tax on net investment income and does not address any aspects of U.S. state or local or non-U.S. taxation. This summary only applies to U.S. Holders holding our ordinary shares as “capital assets” within the meaning of Section 1221 of the Code (generally, property held for investment).

If an entity classified for U.S. federal income tax purposes as a partnership owns our ordinary shares, the tax treatment of a member of the entity will depend on the status of the member and the activities of the entity and such member. The tax treatment of such an entity, and of any member of such an entity, is not addressed in this summary. Any entity that is classified for U.S. federal income tax purposes as a partnership and that owns our ordinary shares, and any members of such an entity, are encouraged to consult their respective tax advisors.

U.S. HOLDERS OF OUR ORDINARY SHARES ARE ENCOURAGED TO SEEK ADVICE FROM THEIR OWN TAX ADVISORS REGARDING THE INCOME TAX CONSEQUENCES OF THE REVERSE SHARE SPLIT TAKING INTO ACCOUNT THEIR PARTICULAR SITUATIONS AS WELL AS ANY TAX CONSEQUENCES OF THE REVERSE SHARE SPLIT ARISING UNDER THE U.S. FEDERAL INCOME, ESTATE OR GIFT TAX LAWS OR UNDER THE LAWS OF ANY STATE, LOCAL OR NON-U.S. TAXING JURISDICTION OR UNDER ANY APPLICABLE INCOME TAX TREATY.

We intend for the reverse share split to qualify as a “recapitalization” for U.S. federal income tax purposes and, consequently, as a “reorganization” within the meaning of Section 368(a) of the Code. Assuming the reverse share split so qualifies:

U.S. Treasury regulations provide detailed rules for allocating the tax basis and holding period among our ordinary shares acquired by a shareholder on different dates and at different prices. U.S. Holders that acquired our ordinary shares on different dates or at different prices should consult their tax advisors regarding the allocation of the tax basis and holding period among such ordinary shares.

Procedures for Effecting Reverse Share Split

As soon as practicable after the effective date of the reverse share split, the Company’s shareholders will be notified that the reverse share split has been effected.

Registered “Book-Entry” Holders of Ordinary Shares

As all of the outstanding ordinary shares are held in book-entry form, you will not need to take any action to receive post-reverse share split ordinary shares. As soon as practicable after the effective time, the Company’s transfer agent will send to your registered address a transmittal letter along with a statement of ownership indicating the number of post-reverse share split ordinary shares you hold.

Beneficial Holders of Ordinary Shares

Upon the implementation of the reverse share split, we intend to treat ordinary shares held by shareholders in “street name” (i.e., through a bank, broker, custodian, or other nominee), in the same manner as registered “book-entry” holders of our ordinary shares. Banks, brokers, custodians or other nominees will be instructed to effect the reverse share split for their beneficial holders holding our ordinary shares in street name. However, these banks, brokers, custodians or other nominees may have different procedures than registered shareholders for processing the reverse share split. If a shareholder holds our ordinary shares with a bank, broker, custodian, or other nominee and has any questions in this regard, he, she or it is encouraged to contact his, her or its bank, broker, custodian, or other nominee.

Proposed Resolutions

At the extraordinary general meeting, our Board will present to our shareholders a resolution that reflects a reverse split ratio of between 1-for-15 and 1-for-25 for approval within the range to be approved, subject to the determination of the Board based on market conditions and the market price of the ordinary shares during the period leading up to, and immediately prior to, the meeting. We have assumed the approval of the Authorized Share Capital Increase Proposal prior to the adoption of the Reverse Share Split Proposal, thereby increasing the current (pre-reverse share split) authorized share capital to US$69,646,500 divided into 515,900,000 ordinary shares of a par value of US$0.135 each. Text showing the proposed amendment to our Amended and Restated Memorandum of Association in respect of the Reverse Share Split Proposal is set forth inAnnex C to this proxy statement:

RESOLVED, as an ordinary resolution, that, subject to the determination, confirmation and approval of the board of directors of the Company that this resolution is an effective means of maintaining compliance with the minimum bid price requirement for the continued listing of the ordinary shares of the Company on the Nasdaq Capital Market, the authorized share capital of the Company (after increase pursuant to the adoption of the Authorized Share Capital Increase Proposal at the Meeting) be consolidated at a ratio of between 1-for-15 and 1-for-25 as follows:

from US$69,646,500 divided into 515,900,000 ordinary shares of a par value of US$0.135 each,

to US$69,646,500 divided into 34,393,333 ordinary shares of a par value of US$2.025 each

by

(a) the consolidation of all issued ordinary shares (as of September 30, 2026, 14,473,292 issued shares) of a par value of US$0.135 into issued ordinary shares (based on the number of issued shares as of such date, 964,886 issued ordinary shares) of a par value of US$2.025, and

(b) the consolidation of all unissued ordinary shares (as of September 30, 2026, as adjusted to reflect an increase due to the adoption of the Authorized Share Capital Increase Proposal at the meeting, 501,426,708 unissued shares) of a par value of US$0.135 into unissued ordinary shares (as of such date, and assuming the adoption of the Authorized Share Capital Increase Proposal at the meeting, 33,428,447 unissued shares) of a par value of US$2.025.

RESOLVED, as an ordinary resolution, that, subject to the determination, confirmation and approval of the board of directors of the Company that this resolution is an effective means of maintaining compliance with the minimum bid price requirement for the continued listing of the ordinary shares of the Company on the Nasdaq Capital Market, the authorized share capital of the Company (after increase pursuant to the adoption of the Authorized Share Capital Increase Proposal at the Meeting) be consolidated as follows:

from US$69,646,500 divided into 515,900,000 ordinary shares of a par value of US$0.135 each,

to US$69,646,500 divided into 20,636,000 ordinary shares of a par value of US$3.375 each

by

(a) the consolidation of all issued ordinary shares (as of September 30, 2026, 14,473,292 issued shares) of a par value of US$0.135 into issued ordinary shares (based on the number of issued shares as of such date, 578,932 issued ordinary shares) of a par value of US$3.375, and

(b) the consolidation of all unissued ordinary shares (as of September 30, 2026, as adjusted to reflect an increase due to the adoption of the Authorized Share Capital Increase Proposal at the meeting, 501,426,708 unissued shares) of a par value of US$0.135 into unissued ordinary shares (as of such date, and assuming the adoption of the Authorized Share Capital Increase Proposal at the meeting, 20,057,068 unissued shares) of a par value of US$3.375.

Vote Required for Approval

The approval of the Reverse Share Split Proposal requires the affirmative vote of an ordinary resolution under Cayman Islands law, being a resolution passed by an ordinary majority of Silexion’s shareholders as, being entitled to do so, vote in person or by proxy at the extraordinary general meeting and includes a unanimous written resolution.

Board Recommendation

The Board unanimously recommends a vote “FOR” the Reverse Share Split Proposal at a ratio (between 1-for-15 and 1-for-25) to be presented by the Board at the extraordinary general meeting.