BeyondSpring Inc.

On September 29, 2026, the Company entered into an Open Market Sale Agreement (the “Sales Agreement”) with Citizens JMP Securities, LLC, as sales agent and/or principal (the “Agent”), in connection with the Company’s “at-the-market offering” program (the “ATM Program”) under which the Company may offer and sell up to 9,200,000 ordinary shares, par value $0.0001 per share (the “Ordinary Shares”).

Subject to the terms and conditions of the Sales Agreement, the Agent has agreed to use its commercially reasonable efforts to sell the Ordinary Shares from time to time, based upon the Company’s instructions. The Agent will be entitled to a commission at a rate of up to 3.0% of the gross proceeds of such Ordinary Shares sold pursuant to the Sales Agreement. Sales of Ordinary Shares under the Sales Agreement will be made by any method permitted by law that is deemed an “at-the-market offering” as defined in Rule 415 under the Securities Act of 1933, as amended (the “Securities Act”). The Sales Agreement contains customary representations and warranties of the parties and indemnification and contribution provisions under which the Company has agreed to indemnify the Agent against certain liabilities, including liabilities under the Securities Act. The Agent and the Company have the right, by giving written notice as specified in the Sales Agreement, to terminate the Sales Agreement.

The offering has been registered under the Securities Act pursuant to the Company’s shelf registration statement initially filed on Form F-3 and subsequently amended on Form S-3 (Registration Statement No. 333-280153), as supplemented by the Prospectus Supplement dated September 29, 2026 relating to the sale of the Ordinary Shares. This report shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of the Ordinary Shares in any state in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state.

A copy of the Sales Agreement is attached as Exhibit 1.1 hereto and is incorporated herein by reference. The foregoing description of the Sales Agreement does not purport to be complete and is qualified in its entirety by reference to such exhibit.

A copy of the opinion of Maples and Calder (Hong Kong) LLP relating to the validity of the securities to be issued pursuant to the Sales Agreement is filed herewith as Exhibit 5.1.

Item 8.01. Other Events.

On September 29, 2026, the Company issued a press release announcing, among other things, the transactions described above, a copy of which is attached hereto as Exhibit 99.1 and incorporated herein by reference.

Item 9.01. Financial Statements and Exhibits.