ORASURE TECHNOLOGIES INC

We are providing these proxy materials to stockholders of OraSure Technologies, Inc., a Delaware corporation (as used herein, “we,” “us,” “our”, “OraSure”, "OTI" or the “Company”), and we are mailing the materials on or about May 4, 2026, in connection with the Company’s solicitation of proxies for use at the Annual Meeting of Stockholders to be held on Wednesday, June 3, 2026 at 9:00 a.m. (Eastern time), and at any adjournment(s) or postponement(s) thereof (the “Annual Meeting”).

As a stockholder, you are invited to participate in the Annual Meeting and are requested to vote on the matters described in this Proxy Statement. The Annual Meeting will be conducted in a completely virtual manner through a live webcast that you can access online by going to http://www.cesonlineservices.com/osur26_vm. To participate in the Annual Meeting, you must pre-register at http://www.cesonlineservices.com/osur26_vm by 9:00 a.m. (Eastern Time) on June 2, 2026, using your control number. The webcast will not include a presentation by management. A question and answer session will be provided at the Annual Meeting only for questions that are germane to the matters being discussed and voted on at the meeting.

This summary highlights information contained elsewhere in this Proxy Statement but does not contain all of the information that you should consider. You should read the entire Proxy Statement carefully before voting your shares.