BICYCLE THERAPEUTICS PLC

Previous wording

Our internal programs are focused on oncology indications with high unmet medical need. Our product candidate, nuzefatide pevedotin (formerly BT5528), is a Bicycle Drug Conjugate, or a BDC® molecule, whereby the Bicycle molecules are chemically attached to a toxin that, when administered, is cleaved from the Bicycle molecule and kills the tumor cells. We are evaluating nuzefatide pevedotin, a BDC molecule targeting Ephrin type A receptor 2, or EphA2, and carryinga monomethyl auristatin E, or MMAE, cytotoxin payload, in both an ongoing company-sponsored Phase I/II clinical trial to assess the safety, pharmacokinetics and clinical activity of nuzefatide pevedotin in patients with advanced solid tumors and an ongoing company-sponsored Phase II clinical trial to evaluate the efficacy, safety and pharmacokinetics of nuzefatide pevedotin in adult patients with recurrent metastatic pancreatic ductal adenocarcinoma. The ongoing company-sponsored Phase II clinical trial commenced recruiting patients in the first quarter of 2026 and we announced that the first patient was dosed in April 2026. In addition, in April 2026, we announced Phase I/II clinical results for nuzefatide pevedotin in combination with nivolumab in patients with metastatic urothelial cancer at the American Association for Cancer Research, or AACR, Annual Meeting 2026. We also announced preclinical assessments of nuzefatide pevedotin anti-tumor activity in xenograft models of pancreatic ductal adenocarcinoma and head and neck squamous cell carcinoma.

Current wording

Our internal programs are focused on oncology indications with high unmet medical need. Our product candidate, nuzefatide pevedotin (formerly BT5528), is a Bicycle Drug Conjugate, or a BDC® molecule, whereby the Bicycle molecules are chemically attached to a toxin that, when administered, is cleaved from the Bicycle molecule and kills the tumor cells. We are evaluating nuzefatide pevedotin, a BDC molecule targeting Ephrin type A receptor 2, or EphA2, and carryinga monomethyl auristatin E, or MMAE, cytotoxin payload, in both an ongoing company-sponsored Phase I/II clinical trial to assess the safety, pharmacokinetics and clinical activity of nuzefatide pevedotin in patients with advanced solid tumors and an ongoing company-sponsored Phase II clinical trial to evaluate the efficacy, safety and pharmacokinetics of nuzefatide pevedotin in adult patients with recurrent metastatic pancreatic ductal adenocarcinoma. The ongoing company-sponsored Phase II clinical trial commenced recruiting patients in the first quarter of 2026 and we announced that the first patient was dosed in April 2026. In addition, in April 2026, we announced Phase I/II clinical results for nuzefatide pevedotin in combination with nivolumab in patients with metastatic urothelial cancer at the American Association for Cancer Research, or AACR, Annual Meeting 2026. We also announced preclinical assessments of nuzefatide pevedotin anti-tumor activity in xenograft models of pancreatic ductal adenocarcinoma and head and neck squamous cell carcinoma. In September 2026, the U.S. Food and Drug Administration, or FDA, granted nuzefatide pevedotin orphan drug designation for the treatment of pancreatic cancer.

Previous wording

We are also developing BT1702, a Bicycle Radioconjugate, or BRC®, molecule targeting Membrane Type 1 matrix metalloproteinase, or MT1-MMP, and carrying a lead-212, or 212 Pb, radioisotope payload for theranostic use. We are currently conducting Investigational New Drug application, or IND, -enabling activities for BT1702. We are also developing Bicycle Imaging Agents, or BIA molecules, whereby a Bicycle molecule is linked to achelated radiopharmaceutical imaging agent. We are using BIA molecules to potentially derisk novel targets prior to further clinical development and to efficiently triage cancer indications for subsequent treatment with both BRC and/or BDC

Current wording

We are also developing BT1702, a Bicycle Radioconjugate, or BRC®, molecule targeting Membrane Type 1 matrix metalloproteinase, or MT1-MMP, and carrying a lead-212, or 212 Pb, radioisotope payload for theranostic use. We are currently conducting Investigational New Drug application, or IND, -enabling activities for BT1702. We are also developing Bicycle Imaging Agents, or BIA molecules, whereby a Bicycle molecule is linked to achelated radiopharmaceutical imaging agent. We are using BIA molecules to potentially derisk novel targets prior to further

Previous wording

molecules. Our discovery pipeline in oncology includes next-generation BDC molecules, BRC molecules and BIA molecules. In April 2026, additional human imaging data of a BIA molecule targeting EphA2 in patients with pancreatic ductal adenocarcinoma was presented by the German Cancer Consortium, or DKTK, at the AACR Annual Meeting 2026.

Current wording

clinical development and to efficiently triage cancer indications for subsequent treatment with both BRC and/or BDC molecules. Our discovery pipeline in oncology includes next-generation BDC molecules, BRC molecules and BIA molecules. In April 2026, additional human imaging data of a BIA molecule targeting EphA2 in patients with pancreatic ductal adenocarcinoma was presented by the German Cancer Consortium, or DKTK, at the AACR Annual Meeting 2026.

Previous wording

Our other product candidate, BT7480, is a Bicycle Tumor-Targeted Immune Cell Agonist®, or Bicycle TICA® molecule. A Bicycle TICA molecule links immune cell receptor binding Bicycle molecules to tumor antigen binding Bicycle molecules. BT7480, a Bicycle TICA molecule targeting Nectin-4 and agonizing CD137, is being evaluated in a company-sponsored Phase I/II clinical trial. After reporting certain data from the clinical trial in 2026, we will no longer develop BT7480 internally and intend to explore partnership opportunities for future development.

Current wording

Our other product candidate, BT7480, is a Bicycle Tumor-Targeted Immune Cell Agonist®, or Bicycle TICA® molecule. A Bicycle TICA molecule links immune cell receptor binding Bicycle molecules to tumor antigen binding Bicycle molecules. BT7480, a Bicycle TICA molecule targeting Nectin-4 and agonizing CD137, is being evaluated in a company-sponsored Phase I/II clinical trial. In October 2026, we presented updated Phase I/II clinical results for BT7480 in combination with nivolumab in patients with advanced solid tumors at the European Society for Medical Oncology, or ESMO, Congress 2026. We are no longer developing BT7480 internally and we intend to explore partnership opportunities for future development.

Previous wording

In March 2026, we announced the strategic reprioritization of our clinical portfolio to focus on our promising pipeline of next-generation therapeutics, including nuzefatide pevedotin as well as next-generation Bicycle conjugates, including BRC molecules. In connection with the strategic reprioritization, we announced a workforce reduction of approximately 30% of our workforce. Together, the workforce reduction and strategic reprioritization are expected to reduce our annual operating expenses by approximately 50% based on our current plans. We expect the workforce reduction to be substantially completed by the end of 2026, and that we will incur aggregate charges of approximately $6.5 million, representing cash expenditure for severance and other employee termination benefits, of which $1.3 million and $5.5 million was recognized during the three and six months ended June 30, 2026, respectively.

Current wording

In March 2026, we announced the strategic reprioritization of our clinical portfolio to focus on our promising pipeline of next-generation therapeutics, including nuzefatide pevedotin as well as next-generation Bicycle conjugates, including BRC molecules. In connection with the strategic reprioritization announced in March 2026, we announced a workforce reduction of approximately 30% of our workforce. Together, the workforce reduction and strategic reprioritization are expected to reduce our annual operating expenses by approximately 50% based on our current plans. We expect the workforce reduction to be substantially completed by the end of 2026, and that we will incur aggregate charges of approximately $6.1 million, representing cash expenditure for severance and other employee termination benefits, of which $0.3 million and $5.8 million was recognized during the three and nine months ended September 30, 2026, respectively.

Previous wording

Since our inception, we have devoted substantially all of our resources to developing our Bicycle platform and our product candidates, conducting research and development of our product candidates and preclinical programs, raising capital and providing general and administrative support for our operations. To date, we have financed our operations primarily with proceeds from the sale of equity securities; proceeds received from upfront payments, research and development payments, and development milestone payments from our collaboration agreements; and loan borrowings. From our inception through June 30, 2026, we have received gross proceeds of $1.4 billion from the sale of equity securities; and $240.2 million of cash payments under collaboration arrangements, including $46.8 million from

Current wording

operations primarily with proceeds from the sale of equity securities; proceeds received from upfront payments, research and development payments, and development milestone payments from our collaboration agreements; and loan borrowings. From our inception through September 30, 2026, we have received gross proceeds of $1.4 billion from the sale of equity securities; and $240.6 million of cash payments under collaboration arrangements, including $47.2 million from Bayer Consumer Care AG, or Bayer, $53.0 million from Novartis Pharma AG, or Novartis, $49.7 million from Ionis Pharmaceuticals, Inc., or Ionis, and $56.0 million from Genentech Inc., or Genentech. We do not have any products approved for sale and have not generated any revenue from product sales.

Previous wording

Since our inception, we have incurred significant operating losses. Our ability to generate product revenue sufficient to achieve profitability will depend on the successful development and eventual commercialization of one or more of our product candidates. Our net losses were $50.3 million and $111.2 million for the three and six months ended June 30, 2026, respectively. As of June 30, 2026, we had an accumulated deficit of $1.0 billion. These losses have resulted primarily from costs incurred in connection with research and development activities and general and administrative costs associated with our operations. We expect to continue to incur significant expenses and increasing operating losses for the foreseeable future.

Current wording

Since our inception, we have incurred significant operating losses. Our ability to generate product revenue sufficient to achieve profitability will depend on the successful development and eventual commercialization of one or more of our product candidates. Our net losses were $10.5 million and $121.6 million for the three and nine months ended September 30, 2026, respectively. As of September 30, 2026, we had an accumulated deficit of $1.0 billion. These losses have resulted primarily from costs incurred in connection with research and development activities and general and administrative costs associated with our operations. We expect to continue to incur significant expenses and increasing operating losses for the foreseeable future.

Previous wording

and governmental grants, monetization transactions or licensing arrangements. We may be unable to raise additional funds or enter into such other agreements or arrangements when needed on favorable terms, or at all. If we fail to raise capital or enter into such agreements as, and when, needed, we may have to significantly delay, scale back, or discontinue the development and commercialization of one or more of our product candidates. Because of the numerous risks and uncertainties associated with product development, we are unable to predict the timing or amount of increased expenses or when or if we will be able to achieve or maintain profitability. Even if we are able to generate product sales, we may not become profitable. If we fail to become profitable or are unable to sustain profitability on a continuing basis, we may be unable to continue our operations at planned levels and be forced to reduce or terminate our operations.

Current wording

As a result, we will need substantial additional funding to support our continuing operations and pursue our growth strategy. Until such time as we can generate significant revenue from product sales, if ever, we expect to finance our operations through a combination of equity offerings, debt financings, collaborations, strategic alliances, charitable and governmental grants, monetization transactions or licensing arrangements. We may be unable to raise additional funds or enter into such other agreements or arrangements when needed on favorable terms, or at all. If we fail to raise capital or enter into such agreements as, and when, needed, we may have to significantly delay, scale back, or discontinue the development and commercialization of one or more of our product candidates. Because of the numerous risks and uncertainties associated with product development, we are unable to predict the timing or amount of increased expenses or when or if we will be able to achieve or maintain profitability. Even if we are able to generate product sales, we may not become profitable. If we fail to become profitable or are unable to sustain profitability on a continuing basis, we may be unable to continue our operations at planned levels and be forced to reduce or terminate our operations.

Previous wording

As of June 30, 2026, we had cash and cash equivalents of $510.1 million. We believe that our existing cash and cash equivalents will enable us to fund our operating expenses and capital expenditure requirements for at least 12 months from the date of filing of this Quarterly Report. We have based this estimate on assumptions that may prove to be wrong, and we could deplete our available capital resources sooner than we expect. See “—Liquidity and Capital Resources” and “—Capital Resources and Funding Requirements.”

Current wording

As of September 30, 2026, we had cash and cash equivalents of $469.9 million. We believe that our existing cash and cash equivalents will enable us to fund our operating expenses and capital expenditure requirements for at least 12 months from the date of filing of this Quarterly Report. We have based this estimate on assumptions that may prove to be wrong, and we could deplete our available capital resources sooner than we expect. See “—Liquidity and Capital Resources” and “—Capital Resources and Funding Requirements.”

Previous wording

To date, we have not generated any revenue from product sales and we do not expect to generate any revenue from product sales for the foreseeable future. Our revenue primarily consists of collaboration revenue under our arrangements with our collaboration partners, including amounts that are recognized related to upfront payments, milestone payments and option exercise payments, amounts due to us for research and development services and reimbursement of certain expenses incurred. In the future, revenue may include additional milestone payments and option exercise payments, and royalties on any net product sales under our collaborations. In the near term, we expect that revenue may decrease as a result of the terminations of our collaboration agreements with Genentech and Novartis, effective in August 2025 and February 2026, respectively. In addition, in July 2026, Bayer provided us with a notice of termination of our collaboration agreement, to be effective in September 2026 after a contractual 60-day notice period, and as such the remaining deferred revenue under the arrangement of approximately $33.2 million is expected to be recognized in the third quarter of 2026. In the future, we expect that any revenue we generate will fluctuate from period to period as a result of the timing and amount of license, research and development services, milestone and other payments, as well as the exercise or expiration of options.

Current wording

To date, we have not generated any revenue from product sales and we do not expect to generate any revenue from product sales for the foreseeable future. Our revenue primarily consists of collaboration revenue under our arrangements with our collaboration partners, including amounts that are recognized related to upfront payments, milestone payments and option exercise payments, amounts due to us for research and development services and reimbursement of certain expenses incurred. In the future, revenue may include additional milestone payments and option exercise payments, and royalties on any net product sales under our collaborations. In the near term, we expect that revenue will decrease as a result of the terminations of our collaboration agreements with Bayer, Novartis and Genentech effective in September 2026, February 2026 and August 2025, respectively. In the future, we expect that any revenue we generate will fluctuate from period to period as a result of the timing and amount of license, research and development services, milestone and other payments, as well as the exercise or expiration of options under collaboration arrangements.

Previous wording

Through our subsidiaries in the U.K., we receive reimbursements of certain research and development expenditures as part of a U.K. government research and development tax reliefs program. The Finance Act 2024, which was enacted in February 2024, replaced the legacy research and development expenditure credit and the Small and Medium-sized Enterprise, or SME, R&D Tax Relief program with a merged research and development expenditure credit scheme, or RDEC, and an enhanced research and development intensive support scheme, or ERIS. The Finance Act 2024 provides for a cash rebate that may be claimed for 26.97% of qualifying expenditure if we qualify as R&D intensive for an accounting period. We qualified as R&D intensive for the year ended December 31, 2025, and we expect to qualify as R&D intensive for the year ended December 31, 2026.

Current wording

Through our subsidiaries in the U.K., we receive reimbursements of certain research and development expenditures as part of a U.K. government research and development tax reliefs program. The Finance Act 2024, which was enacted in February 2024, replaced the legacy research and development expenditure credit and the Small and Medium-sized Enterprise, or SME, R&D Tax Relief program with a merged research and development expenditure credit scheme, or RDEC, and an enhanced research and development intensive support scheme, or ERIS. The Finance Act 2024 provides for a cash rebate that may be claimed for 26.97% of qualifying expenditure if we qualify as R&D intensive for an accounting period. We qualified as R&D intensive for the year ended December 31, 2025, and we expect to qualify as R&D intensive for the year ending December 31, 2026.

Previous wording

After consideration of our history of cumulative net losses in the U.K., we have concluded that it is more likely than not that we will not realize the benefits of our U.K. deferred tax assets and accordingly we have provided a valuation allowance for the full amount of the net deferred tax assets in the U.K. We intend to continue to maintain a full valuation allowance on our U.K. deferred tax assets until there is sufficient evidence to support the reversal of all or some portion of these allowances. The release of the valuation allowance would result in the recognition of certain deferred tax assets and an increase to the benefit from income taxes for the period the release is recorded. However, the exact timing and amount of the valuation allowance release are subject to change on the basis of the level of profitability that we are able to actually achieve.

Current wording

After consideration of our history of cumulative net losses in the U.K., we have concluded that it is more likely than not that we will not realize the benefits of our U.K. deferred tax assets and accordingly we have provided a valuation allowance for the full amount of the net deferred tax assets in the U.K. We will maintain a full valuation allowance on our U.K. deferred tax assets until there is sufficient evidence to support the reversal of all or some portion of these allowances. The release of the valuation allowance would result in the recognition of certain deferred tax assets and an increase to the benefit from income taxes for the period the release is recorded. However, the exact timing and amount of the valuation allowance release are subject to change on the basis of the level of profitability that we are able to actually achieve.

Previous wording

Research and development expenses decreased by $40.0 million in the six months ended June 30, 2026 compared to the six months ended June 30, 2025, primarily due to decreases of $36.1 million in clinical program expenses for zelenectide pevedotin as the dose selection portion of the Duravelo-2 clinical trial was fully enrolled throughout the six months ended June 30, 2026, resulting in decreased expense period over period, $5.4 million and $2.9 million in employee and contractor related expenses and share-based compensation, respectively, primarily due to decreased headcount period over period resulting from our workforce reductions announced in August 2025 and March 2026, and $4.3 million in discovery, platform and other expense due to the timing of preclinical activities for our pipeline programs. These decreases were offset by $8.3 million of lower research and development incentives associated

Current wording

September 30, 2026, and the program has been deprioritized for internal development, resulting in decreased expense period over period, $5.9 million and $1.8 million in employee and contractor related expenses and share-based compensation, respectively, primarily due to decreased headcount period over period associated with our workforce reductions announced in August 2025 and March 2026, and $2.5 million in discovery, platform and other expense due to the timing of preclinical activities for our pipeline programs. These decreases were offset by $2.8 million lower research and development incentives associated with the corresponding decrease in qualifying research and development expenses period over period.

Previous wording

We begin to separately track program expenses at candidate nomination, at which point we accumulate all direct external program costs to support that program to date. Through June 30, 2026, we have incurred approximately $324.1 million and $61.9 million of direct external expenses for the development of zelenectide pevedotin and nuzefatide pevedotin, respectively, since their candidate nominations, an aggregate of $0.6 million for the development of BT1702 since its candidate nomination, and an aggregate of $52.2 million of direct external expenses for the development of our two named Bicycle TICA molecule candidates since their nominations.

Current wording

We begin to separately track program expenses at candidate nomination, at which point we accumulate all direct external program costs to support that program to date. Through September 30, 2026, we have incurred approximately $334.2 million and $64.0 million of direct external expenses for the development of zelenectide pevedotin and nuzefatide pevedotin, respectively, since their candidate nominations, an aggregate of $1.3 million for the development of BT1702 since its candidate nomination, and an aggregate of $52.2 million of direct external expenses for the development of our two named Bicycle TICA molecule candidates since their nominations.

Previous wording

General and administrative expenses decreased by $8.1 million in the six months ended June 30, 2026 compared to the six months ended June 30, 2025. This decrease was primarily due to decreases of $4.9 million in professional and consulting fees primarily associated with decreased legal and consulting fees period over period, and $2.8 million in share-based compensation primarily due to the impact of our workforce reductions announced in August 2025 and March 2026. In addition, for the six months ended June 30, 2026, we recognized $1.3 million of personnel-related costs for severance and other employee termination benefits associated with our workforce reduction announced in March 2026.

Current wording

General and administrative expenses decreased by $4.7 million in the three months ended September 30, 2026 compared to the three months ended September 30, 2025. This decrease was primarily due to decreases of $2.6 million and $1.6 million in personnel-related costs and share-based compensation, respectively, primarily due to decreased headcount period over period associated with our workforce reductions announced in August 2025 and March 2026.

Previous wording

Other income, net decreased by $3.1 million in the three months ended June 30, 2026 compared to the three months ended June 30, 2025, which was primarily due to a decrease in interest income of $3.1 million due to lower average interest rates as well as lower cash and cash equivalents balances period over period.

Current wording

Other income, net decreased by $2.5 million in the three months ended September 30, 2026 compared to the three months ended September 30, 2025, which was primarily due to a decrease in interest income of $2.5 million due to lower cash and cash equivalents balances period over period.

Previous wording

Research and development expenses decreased by $29.9 million in the three months ended June 30, 2026 compared to the three months ended June 30, 2025, primarily due to decreases of $24.8 million in clinical program expenses for zelenectide pevedotin as the dose selection portion of the Duravelo-2 clinical trial was fully enrolled throughout the three months ended June 30, 2026, resulting in decreased expense period over period, $5.6 million and $1.5 million in employee and contractor related expenses and share-based compensation, respectively, primarily due to decreased headcount period over period resulting from our workforce reductions announced in August 2025 and March

Current wording

Research and development expenses decreased by $65.0 million in the nine months ended September 30, 2026 compared to the nine months ended September 30, 2025, primarily due to decreases of $53.4 million in clinical program expenses for zelenectide pevedotin as the Duravelo-2 clinical trial was fully enrolled throughout the nine months ended September 30, 2026, and the program has been deprioritized for internal development, resulting in decreased expense period over period, $11.3 million and $4.7 million in employee and contractor related expenses and share-based

Previous wording

2026, and $3.5 million in discovery, platform and other expense due to the timing of preclinical activities for our pipeline programs. These decreases were offset by $5.0 million of lower research and development incentives associated with the corresponding reduction in qualifying research and development expenses period over period. In addition, for the three months ended June 30, 2026, we recognized $0.9 million of employee and contractor related expenses for severance and other employee termination benefits associated with our workforce reduction announced in March 2026.

Current wording

compensation, respectively, primarily due to decreased headcount period over period associated with our workforce reductions announced in August 2025 and March 2026 offset by increased employee and contractor related expenses for severance and other employee termination benefits period over period, and $6.7 million in discovery, platform and other expense due to the timing of preclinical activities for our pipeline programs. These decreases were offset by $11.1 million lower research and development incentives associated with the corresponding decrease in qualifying research and development expenses period over period, as well as an increase in program expenses of $1.3 million for BT1702 due to ongoing IND-enabling activities.

Previous wording

General and administrative expenses decreased by $4.5 million in the three months ended June 30, 2026 compared to the three months ended June 30, 2025. This decrease was primarily due to decreases of $1.8 million in professional and consulting fees primarily associated with decreased legal and consulting fees period over period, $1.5 million and $1.4 million in share-based compensation and personnel-related costs, respectively, primarily due to decreased headcount period over period resulting from our workforce reductions announced in August 2025 and March 2026. In addition, for the three months ended June 30, 2026, we recognized $0.4 million of personnel-related costs for severance and other employee termination benefits associated with our workforce reduction announced in March 2026.

Current wording

General and administrative expenses decreased by $12.9 million in the nine months ended September 30, 2026 compared to the nine months ended September 30, 2025. This decrease was primarily due to decreases of $5.3 million in professional and consulting fees primarily associated with decreased legal and consulting fees period over period, as well as decreases of $4.4 million and $3.5 million in share-based compensation and personnel-related costs, respectively, primarily due to decreased headcount period over period associated with our workforce reductions announced in August 2025 and March 2026, offset by increased employee and contractor related expenses for severance and other employee termination benefits period over period.

Previous wording

Other income, net decreased by $6.7 million in the six months ended June 30, 2026 compared to the six months ended June 30, 2025, which was primarily due to a decrease in interest income of $6.6 million due to lower average interest rates as well as lower cash and cash equivalents balances period over period.

Current wording

Other income, net decreased by $9.1 million in the nine months ended September 30, 2026 compared to the nine months ended September 30, 2025, which was primarily due to a decrease in interest income of $9.1 million due to lower cash and cash equivalents balances period over period.

Previous wording

The provision for income taxes of $0.3 million for the six months ended June 30, 2026, was primarily the result of timing differences associated with discrete items for the settlement of restricted share units. The benefit from income taxes of $1.3 million for the six months ended June 30, 2025, was primarily the result of deferred tax assets benefited in the United States that do not have a valuation allowance against them because of profits that will be generated by an intercompany service agreement.

Current wording

The provision for income taxes of $1.4 million for the nine months ended September 30, 2026 was primarily due to a decrease in income tax benefits related to the completion of a U.S. research and development tax credit study. The benefit from income taxes of $1.1 million for the nine months ended September 30, 2025, was primarily the result of deferred tax assets benefited in the United States that do not have a valuation allowance against them because of profits that will be generated by an intercompany service agreement.

Previous wording

Net cash used in operating activities for the six months ended June 30, 2026 was $115.5 million as compared to $159.2 million for the six months ended June 30, 2025. The decrease in cash used in operations of $43.6 million was primarily due to a decrease in cash payments for clinical program activities, primarily related to clinical trials for zelenectide pevedotin as the dose selection portion of the Duravelo-2 clinical trial was fully enrolled throughout the six months ended June 30, 2026, resulting in reduced cash payments, and the prior year included higher payments associated with the initiation of the Phase I/II clinical trial for zelenectide pevedotin in patients with NECTIN4 amplified advanced breast cancer.

Current wording

Net cash used in operating activities for the nine months ended September 30, 2026 was $155.8 million as compared to $230.3 million for the nine months ended September 30, 2025. The decrease in cash used in operations of $74.5 million was primarily due to a decrease in cash payments for clinical program activities, primarily related to clinical trials for zelenectide pevedotin as the Duravelo-2 clinical trial was fully enrolled throughout the nine months ended September 30, 2026, and the program has been deprioritized for internal development, resulting in reduced cash payments, and the prior year included higher payments associated with the initiation of the Phase I/II clinical trials for zelenectide pevedotin in patients with NECTIN4 amplified advanced breast cancer and NECTIN4 amplified advanced or metastatic non-small cell lung cancer.

Previous wording

During the six months ended June 30, 2026 and 2025, we used $1.0 million and $1.1 million, respectively, of cash in investing activities for purchases of property and equipment, consisting primarily of laboratory equipment.

Current wording

During the nine months ended September 30, 2026 and 2025, we used $1.3 million and $1.8 million, respectively, of cash in investing activities for purchases of property and equipment, consisting primarily of laboratory equipment.

Previous wording

During each of the six months ended June 30, 2026 and 2025, net cash used in financing activities was $0.1 million, primarily consisting of principal payments on finance lease obligations.

Current wording

During each of the nine months ended September 30, 2026 and 2025, net cash used in financing activities was $0.1 million, primarily consisting of principal payments on finance lease obligations.

Previous wording

As of June 30, 2026, we had cash and cash equivalents of $510.1 million. We expect that our existing cash and cash equivalents will enable us to fund our operating expenses and capital expenditure requirements for at least 12 months from the date of filing of this Quarterly Report.

Current wording

As of September 30, 2026, we had cash and cash equivalents of $469.9 million. We expect that our existing cash and cash equivalents will enable us to fund our operating expenses and capital expenditure requirements for at least 12 months from the date of filing of this Quarterly Report.

Previous wording

Until such time, if ever, that we can generate product revenue sufficient to achieve profitability, we expect to finance our cash needs through a combination of equity offerings, debt financings, collaborations, monetization transactions, government contracts or other strategic transactions. To the extent that we raise additional capital through the sale of equity, ownership interests of existing holders of our ADSs and ordinary shares will be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect the rights of holders of our ADSs or ordinary shares. If we raise additional funds through collaboration agreements, strategic alliances, licensing arrangements, monetization transactions, or marketing and distribution arrangements, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs or product candidates or grant licenses on terms that may not be favorable to us or grant rights to develop and market products or product candidates that we would otherwise prefer to develop and market ourselves. Future debt financing, if available, may involve covenants restricting our operations or our ability to incur additional debt. Any debt or equity financing that we raise may contain terms that are not favorable to us or our shareholders.

Current wording

Until such time, if ever, that we can generate product revenue sufficient to achieve profitability, we expect to finance our cash needs through a combination of equity offerings, debt financings, collaborations, monetization transactions, government contracts or other strategic transactions. To the extent that we raise additional capital through the sale of equity, ownership interests of existing holders of our ADSs and ordinary shares will be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect the rights of holders of our ADSs or ordinary shares. If we raise additional funds through collaboration agreements, strategic alliances, licensing arrangements, monetization transactions, or marketing and distribution arrangements, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs or product candidates or grant licenses on terms that may not be favorable to us or grant rights to develop and market products or product candidates that we would