Annovis Bio, Inc.

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Malvern, Pennsylvania 19355

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PROXY STATEMENT

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ANNUAL MEETING OF STOCKHOLDERS

To Be Held June 17, 2026

IMPORTANT NOTICE REGARDING THE INTERNET AVAILABILITY OF PROXY MATERIALS FOR THE ANNUAL STOCKHOLDER MEETING TO BE HELD ON WEDNESDAY, JUNE 17, 2026: Copies of this Proxy Statement and the accompanying form of proxy card, and 2025 Annual Report on Form 10-K (the “Annual Report”) are available at www.web.viewproxy.com/annovisbio/2026, using your Virtual Control Number that was included in the Notice of Internet Availability of Proxy Materials you received in the mail. If you want to receive a paper or e-mail copy of these documents, you must request one. There is no charge for requesting a copy. Please choose one of the following methods to make your request:

BY INTERNET: http://www.web.viewproxy.com/annovisbio/2026

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BY TELEPHONE:1-877-777-2857

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BY E-MAIL*: requests@viewproxy.com

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If requesting materials by e-mail, please send a blank e-mail with your Virtual Control Number that was included in the Notice of Internet Availability of Proxy Materials.

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This Proxy Statement and the accompanying proxy card, the foregoing Notice of Internet Availability of Proxy Materials and the Annual Report are intended to be sent or given to stockholders of Annovis Bio, Inc. (the “Company,” “Annovis,” “we,” “us” or “our”) on or about May 4, 2026, in connection with the solicitation of proxies on behalf of our Board of Directors (the “Board”) for use at our 2026 Annual Meeting of Stockholders (the “Annual Meeting”), to be held on Wednesday, June 17, 2026, at 10:00 a.m., Eastern Daylight Time (EDT), virtually at www.web.viewproxy.com/Annovisbio/2026, and at any adjournment or postponement thereof.