Voyager Therapeutics, Inc.

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PROXY STATEMENT

FOR THE 2026 ANNUAL MEETING OF STOCKHOLDERS

To be held on June 9, 2026

INFORMATION CONCERNING SOLICITATION AND VOTING

This proxy statement contains information about the 2026 Annual Meeting of Stockholders of Voyager Therapeutics, Inc. (the “Annual Meeting”), which will be held on Tuesday, June 9, 2026, at 9:00 a.m. Eastern Time exclusively via the Internet in a virtual meting format atwww.virtualshareholdermeeting.com/VYGR2026 (the “Annual Meeting Website”). The Board of Directors of Voyager Therapeutics, Inc. is using this proxy statement to solicit proxies for use at the Annual Meeting. In this proxy statement, unless expressly stated otherwise or the context otherwise requires, the use of “Voyager,” “Company,” “our,” “we” or “us” refers to Voyager Therapeutics, Inc.

If you plan to attend the Annual Meeting, we recommend that you visit the Annual Meeting Website and log in with your 16-digit control number prior to the start time of 9:00 a.m. Eastern Time to ensure that you are fully logged in when the Annual Meeting begins. If you attend the Annual Meeting, you may vote your shares electronically during the Annual Meeting even if you have previously returned your proxy card or completed your proxy by phone or on the Internet. Stockholders wishing to vote their shares electronically during the Annual Meeting should refer to their Notice of Internet Availability of Proxy Materials (the “Notice”), for instructions regarding voting electronically during the Annual Meeting. Stockholders will not be able to attend the Annual Meeting in person.

All properly submitted proxies will be voted in accordance with the instructions contained in those proxies. If no instructions are specified, the proxies will be voted in accordance with the recommendation of our Board of Directors with respect to each of the matters set forth in the Notice. You may revoke your proxy at any time before it is exercised during the Annual Meeting by giving our Corporate Secretary (our “Secretary”) written notice to that effect by using the contact information below.

Our 2025 Annual Report on Form 10-K for the fiscal year ended December 31, 2025 (the “2025 Annual Report on Form 10-K”), and accompanying proxy statement (together, the “Proxy Materials”), are first being made available to stockholders on or about April 28, 2026.

Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting to be Held on June 9, 2026:

The Proxy Materials are available for viewing, printing and downloading at www.proxyvote.com, and at your request printed versions of the Proxy Materials can be delivered to you by mail, in connection with the Board of Directors’ solicitation of proxies for our Annual Meeting, and any adjournment or postponement of the Annual Meeting. If you requested printed versions of these materials by mail, they will also include a proxy card for the Annual Meeting.

A copy of our 2025 Annual Report on Form 10-K as filed with the Securities and Exchange Commission (the “SEC”) on March 9, 2026, except for exhibits, will be furnished without charge to any stockholder upon oral or written request to Voyager Therapeutics, Inc., 75 Hayden Avenue, Lexington, Massachusetts 02421, Attention: Secretary, Telephone: (857) 259-5340. The Proxy Materials are also available on the SEC’s website at http://www.sec.gov, and on our website at https://ir.voyagertherapeutics.com/financial-information/sec-filings.

Pursuant to rules adopted by the SEC we are providing access to our Proxy Materials over the Internet. Accordingly, we are sending a Notice, to our stockholders of record and beneficial owners as of the record date identified below. The mailing of the Notice to our stockholders is scheduled to begin on or around April 28, 2026.