LEXICON PHARMACEUTICALS, INC.

Upon stockholder approval of the proposed amendment and the election by our board of directors to effect a reverse stock split, such reverse stock split would become effective as of the filing of a certificate of amendment to our Sixth Amended and Restated Certificate of Incorporation, in substantially the form attached as Appendix C to this proxy statement, with the Secretary of State of the State of Delaware. Upon filing of the certificate of amendment, and without any further action by us or our stockholders, the issued shares of common stock held by stockholders of record as of the effective date of the reverse stock split would be converted into a lesser number of shares of common stock calculated in accordance with the reverse stock split ratio selected by our board of directors and set forth in the certificate of amendment.

Beginning on the effective date of the reverse stock split, each stock certificate representing pre-split shares of our common stock will be deemed for all corporate purposes to evidence ownership of post-split shares of our common stock. Stockholders will be notified that the reverse stock split has been effected as soon as practicable after the effective date of the reverse stock split.