ATOSSA THERAPEUTICS, INC.

In accordance with the requirements of the Dodd-Frank Wall Street Reform and Consumer Protection Act (the “Dodd-Frank Act”) and Section 14A of the Exchange Act, we are providing our stockholders with the opportunity to cast a non-binding, advisory vote to approve the compensation of our named executive officers (the “say-on-pay” vote).

The say-on-pay vote is a non-binding, advisory vote on the compensation of the Company’s “named executive officers,” as described in this Proxy Statement under the caption “Executive Compensation,” including in the tabular disclosure regarding such compensation and in the accompanying narrative disclosure. The say-on-pay vote is not a vote on the Company’s general compensation policies or the compensation of the Company’s Board.

Our philosophy in setting compensation policies for executive officers has two fundamental objectives: (1) to attract and retain a highly skilled team of executives and (2) to align our executives’ interests with those of our stockholders by rewarding short-term and long-term performance and tying compensation to increases in stockholder value. The Compensation Committee believes in a pay for performance culture, meaning that executive compensation should be directly linked both to improvements in corporate performance and accomplishments that are expected to increase stockholder value.

The vote under this Proposal No. 3 is advisory, and therefore not binding on the Company, the Board or our Compensation Committee. However, our Board, including our Compensation Committee, values the opinions of our stockholders and, to the extent there is any significant vote against the executive officer compensation as disclosed in this Proxy Statement, we will consider the outcome of the vote when making future compensation decisions for our named executive officers.

We are required to hold a say-on-pay vote at least once every three years, and, subject to the vote outcome on Proposal 4, our Board’s current policy is to hold a say-on-pay vote on an annual basis. Unless the Board modifies its policy on the frequency of holding say-on-pay advisory votes, after the Annual Meeting, the next say-on-pay vote is expected to occur at our 2026 Annual Meeting of Stockholders.

Stockholders are being asked to approve the following resolution pursuant to this Proposal No. 3:

RESOLVED, that the stockholders of Atossa Therapeutics, Inc. approve, on a non-binding, advisory basis, the compensation of the Company’s “named executive officers” (as defined in the Proxy Statement), as such compensation is described in the Company’s Proxy Statement for the 2025 Annual Meeting of Stockholders under the caption “Executive Compensation,” including in the tabular disclosure regarding such compensation and the accompanying narrative disclosure.

The non-binding, advisory approval of this proposal requires the affirmative vote of a majority of the votes cast on the matter. Abstentions and broker non-votes, if any, are not counted as votes cast, and they will have no effect on the outcome of the proposal.

THE BOARD OF DIRECTORS RECOMMENDS AN ADVISORY VOTE“FOR”PROPOSAL NO. 3.

PROPOSAL NO. 4