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ARROWHEAD PHARMACEUTICALS, INC.

For the period ended Jan 26, 2026. Filed Jan 27, 2026.

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About this filing

What shareholders are asked to vote on at a company's meeting. It is where to find what directors and top executives are paid, and who owns the most shares.

Jan 26, 2026 · Filed Jan 27, 2026

ARWR$58.16+1.2%Stored close · as of Nov 6, 2026
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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No. )

Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐

Check the appropriate box:

☐Preliminary Proxy Statement
☐Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
☒Definitive Proxy Statement
☐Definitive Additional Materials
☐Soliciting Material Under §240.14a-12

ARROWHEAD PHARMACEUTICALS, INC.

(Name of Registrant as Specified in Its Charter)

(Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of filing fee (Check all boxes that apply):

☒No fee required.
☐Fee paid previously with preliminary materials.
☐Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

Notice of Annual Meeting of Stockholders

To Be Held on Thursday, March 19, 2026

Your vote is important, whether or not you expect to attend the Annual Meeting of Stockholders. Stockholders of record are urged to vote via the Internet or telephone as instructed, or if you are voting by mail, to mark, sign and date and promptly return the proxy in the postage-prepaid return envelope provided. Voting promptly will help avoid the additional expense of further solicitation to assure a quorum at the meeting. Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to be Held on Thursday, March 19, 2026: You may access the following proxy materials at www.proxyvote.com before the meeting and at www.virtualshareholdermeeting.com/ARWR2026 during the meeting. • Notice of the 2026 Annual Meeting of Stockholders; • Company’s 2026 Proxy Statement; and • Company’s Annual Report on Form 10-K for the year ended September 30, 2025TO THE STOCKHOLDERS OF ARROWHEAD PHARMACEUTICALS, INC.: NOTICE IS HEREBY GIVEN that the 2026 Annual Meeting of Stockholders of Arrowhead Pharmaceuticals, Inc., a Delaware corporation (the “Company” or “Arrowhead”), will be held on Thursday, March 19, 2026, at 10:00 a.m., Pacific Time (the “Annual Meeting”). This year’s meeting will be a completely “virtual” meeting of stockholders. If you are a stockholder of record, you can attend the Annual Meeting online, vote your shares electronically, and submit your questions during the Annual Meeting by visiting www.virtualshareholdermeeting.com/ARWR2026. Prior to the Annual Meeting, you will be able to vote at www.proxyvote.com or, if you requested printed copies of the proxy materials, by telephone or mail. The Annual Meeting will be held for the purpose of considering and voting upon the following proposals, as more fully described in the accompanying Proxy Statement: 1. To elect the seven directors named in the Proxy Statement to serve as members of the Company’s Board of Directors until the next Annual Meeting or until their successors are duly elected and qualified; 2. To conduct an advisory (non-binding) vote to approve executive compensation; 3. To approve the Arrowhead Pharmaceuticals, Inc. Amended and Restated 2021 Incentive Plan;4. To ratify the selection of KPMG LLP as independent auditors of the Company for the fiscal year ending September 30, 2026; and 5. To transact any other matters that may properly come before the Annual Meeting or any adjournments or postponements thereof. The foregoing items of business are more fully described in the Proxy Statement accompanying this Notice. The Board of Directors has fixed January 22, 2026 as the record date for the meeting. Only stockholders of record at the close of business on that date will be entitled to notice of, and to vote at, the Annual Meeting and any adjournment or postponement thereof.
All stockholders of record are cordially invited to attend the Annual Meeting by visiting www.virtualshareholdermeeting.com/ARWR2026. Instructions for accessing the virtual Annual Meeting are provided in the Proxy Statement. In the event of a technical malfunction or other situation that the meeting chair determines may affect the ability of the Annual Meeting to satisfy the requirements for a meeting of stockholders to be held by means of remote communication under the Delaware General Corporation Law, or that otherwise makes it advisable to adjourn the Annual Meeting, the chair or secretary of the Annual Meeting will convene the meeting at 11:00 a.m., Pacific Time on the date specified above and at the Company’s address specified below solely for the purpose of adjourning the meeting to reconvene at a date, time and physical or virtual location announced by the meeting chair or secretary. Under either of the foregoing circumstances, we will post information regarding the announcement on the Investors page of the Company’s website at ir.arrowheadpharma.com.If you prefer to receive paper copies of our proxy materials, please follow the instructions included in the Notice of Internet Availability. To ensure your representation at the meeting, you are urged to vote via the Internet, or if you requested a printed copy of the proxy materials, by telephone or mail by marking, signing, dating and returning the proxy card or voting instruction form provided with the printed proxy materials as promptly as possible in the postage-prepaid envelope enclosed for that purpose. Any stockholder of record attending the Annual Meeting may vote at the Annual Meeting even if such stockholder has previously returned a proxy.
/s/ Patrick O’BrienPatrick O’BrienSecretaryPasadena, CaliforniaJanuary 26, 2026

Arrowhead Pharmaceuticals, Inc. ● 177 E. Colorado Blvd., Suite 700 ● Pasadena, California 91105

2026 PROXY STATEMENT Table of Contents

General Information Concerning Solicitation and Voting1
Record Date2
Revocability of Proxies2
Voting and Solicitation2
Quorum; Abstentions; Broker Non-Votes2
Deadline for Receipt of Stockholder Proposals3
Proposal One — Election of Directors4
Board Composition and Nominating Process10
Corporate Governance, Environmental and Social Commitment11
Stockholder Communications with Directors12
Board Meetings and Committees13
Director Compensation15
Proposal Two — Advisory Vote to Approve Executive Compensation17
Proposal Three — Vote to Approve the Arrowhead Pharmaceuticals, Inc. Amended and Restated 2021 Incentive Plan18
Executive Compensation24
Compensation Discussion and Analysis24
Our Company24
Business Development26
Platform27
Pipeline28
Executive Compensation Philosophy34
Executive Compensation Program Design35
Governance of Executive Compensation Program35
Individual Compensation Elements38
Employment Arrangements43
Post-Employment Compensation Arrangements43
Other Compensation Policies and Practices43
Tax and Accounting Considerations44
Compensation Risk Assessment46
Compensation Tables47
Proposal Four — Ratification of Appointment of Independent Auditors61
Audit Fees62
Report of the Audit Committee63
Security Ownership of Certain Beneficial Owners and Management64
Equity Compensation Plan Information66
Review and Approval of Related-Party Transactions68
Certain Relationships and Related Transactions, and Director Independence69
ContentsView on SEC.gov

The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.