Caris Life Sciences, Inc.

Extension of Laboratory Lease

On August 8, 2025, Caris MPI, Inc. (“Caris MPI”), a wholly-owned subsidiary of the Company, entered into Amendment No. 3 (the “Amendment”) to that certain Lease Agreement between Caris MPI and WPT Land 2 LP dated March 4, 2019, as amended on June 17, 2019 and October 5, 2021 (as amended, the “Lease Agreement”). The Lease Agreement relates to the Company’s blood-based clinical laboratory located at 4415 Cotton Center Boulevard, Building 5, Phoenix, Arizona 85040. The Amendment extends the term of the Lease Agreement until August 31, 2031 (from its current expiration of July 31, 2026). Under the Amendment, the Company is entitled a free month of rent for August 2025, and thereafter, the base rent will increase by approximately 5% for the year commencing September 1, 2026 and will increase by approximately 3.5% for each year thereafter. The Company retains its right under the Lease Agreement to extend the term of the lease for a further five years at then-current fair market value after the expiration of the extended term.

The foregoing description of the material terms of the Amendment does not purport to be complete and is subject to, and is qualified in its entirety by, reference to the Amendment, which will be filed as an exhibit to the Company’s Quarterly Report on Form 10-Q for the quarterly period ending September 30, 2025.

Disclosure of Trading Arrangements

During the fiscal quarter ended June 30, 2025, none of our directors or officers (as defined in Rule 16a-1(f) under the Exchange Act)adopted orterminated a “Rule 10b5-1 trading arrangement” or a “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408 of Regulation S-K.