Humacyte Inc

Director and Officer Trading Arrangements

On August 16, 2024, Shamik Parikh, the Company’s Chief Medical Officer, adopted a trading arrangement for the sale of Common Stock that is intended to satisfy the affirmative defense conditions provided by Rule 10b5-1(c) under the Exchange Act. (the “Parikh 10b5-1 Plan”). The Parikh 10b5-1 Plan provides for a first possible trade date of November 21, 2024 and terminates automatically on the earlier of the execution of all trades contemplated by the Parikh 10b5-1 Plan, or August 25, 2025. The Parikh 10b5-1 Plan provides for the sale of up to 181,512 shares of Common Stock pursuant to its terms.

On September 13, 2024, Dale Sander, the Company’s Chief Financial Officer, adopted a trading arrangement for the sale of Common Stock that is intended to satisfy the affirmative defense conditions provided by Rule 10b5-1(c) under the Exchange Act. (the “Sander 10b5-1 Plan”). The Sander 10b5-1 Plan provides for a first possible trade date of December 12, 2024 and terminates automatically on the earlier of the execution of all trades contemplated by the Sander 10b5-1 Plan, or September 12, 2025. The Sander 10b5-1 Plan provides for the sale of up to 189,860 shares of Common Stock pursuant to its terms.

Other than as disclosed above, during the three months ended September 30, 2024, no director or officer (as defined in Rule 16a-1(f) under the Exchange Act) of the Company adopted orterminated any “Rule 10b5-1 trading arrangement” or any “non Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K.