PLIANT THERAPEUTICS INC

On August 26, 2024, Mike Ouimette, our General Counsel, adopted a trading plan, or the Ouimette 10b5-1 Sales Plan, intended to satisfy the affirmative defense of Rule 10b5-1(c) under the Exchange Act. Under the Ouimette 10b5-1 Sales Plan, which goes into effect on January 2, 2025, an aggregate of 40,000 shares of the Company’s common stock (such aggregate amount, which may be reduced by any shares sold prior pursuant to a prior trading plan adopted by Mr. Ouimette on October 4, 2023 and prior to initiation of sales pursuant to the Ouimette 10b5-1 Sales Plan) and up to 100% of net shares Mr. Ouimette may receive from the vesting of certain outstanding RSU awards from time to time (the “Ouimette Authorized Shares”) may be sold. Due to vesting conditions of the awards and the number of shares withheld for taxes, to be determined only on the vesting date and market conditions, the number of shares actually sold under the Ouimette 10b5-1 Sales Plan may be less than the maximum number of shares that can be sold. The Ouimette 10b5-1 Sales Plan, which was entered into during an open trading window under the Company’s insider trading policy, will be in effect until the earlier of (1)December 31, 2025, or (2) the date on which all Ouimette Authorized Shares have been sold under the Ouimette 10b5-1 Sales Plan.

On September 26, 2024, Keith Cummings, our Chief Financial Officer, adopted a trading plan, or the Cummings 10b5-1 Sales Plan, intended to satisfy the affirmative defense of Rule 10b5-1(c) under the Exchange Act. Under the Cummings 10b5-1 Sales Plan, which goes into effect on December 26, 2024, an aggregate of 91,434 shares of the Company’s common stock may be sold (such aggregate amount, which may be reduced by any shares sold prior pursuant to a prior trading plan adopted by Dr. Cummings on June 13, 2023 and prior to initiation of sales pursuant to the Cummings 10b5-1 Sales Plan, the “Cummings

Authorized Shares”). The Cummings 10b5-1 Sales Plan, which was entered into during an open trading window under the Company’s insider trading policy, will be in effect until the earlier of (1)December 12, 2025, or (2) the date in which all Cummings Authorized Shares have been sold under the Cummings 10b5-1 Sales Plan.