Zentalis Pharmaceuticals, Inc.

We have developed and implemented a cybersecurity risk management program intended to protect the confidentiality, integrity and availability of our critical systems and information. Our cybersecurity program is aligned with industry standards and reasonable security safeguards for comparable companies in our industry. We reference various security industry frameworks and controls, such as National Institute of Standards and Technology, or NIST, Cybersecurity Framework 2.0, ISO/IEC 27001:2022, the Sarbanes-Oxley Act, Title 21 Code of Federal Regulations Part 11, Network and Information Security Directive 2, and other guidance to help us assess, identify and manage cybersecurity risks. This does not imply that we meet any particular technical standards, specifications, or requirements, only that we use the frameworks and controls as a guide to help us identify, assess, and manage cybersecurity risks relevant to our business. We also actively engage with industry participants as part of our continuing efforts to evaluate and enhance the effectiveness of our information security policies and procedures. From time to time, we engage consultants and other third parties to assist us with assessing and improving our cybersecurity program.

Key elements of our cybersecurity risk management program include but are not limited to the following:

•risk assessments designed to help identify material risks from cybersecurity threats to our critical systems and information;

•the use of external service providers, where appropriate, to assess, test or otherwise assist with aspects of our security processes;

•cybersecurity awareness training of our employees, including incident response personnel and senior management;

•a cyber incident response team and cyber incident response plan that includes procedures for responding to cybersecurity incidents; and

•a third-party risk management process for key service providers based on our assessment of their criticality to our operations and respective risk profile.

We have not identified risks from known cybersecurity threats, including as a result of any prior cybersecurity incidents, that have materially affected us, including our operations, business strategy, results of operations or financial condition. We face risks from cybersecurity threats that, if realized, are reasonably likely to materially affect us, including our operations, business strategy, results of operations, or financial condition. For more information, see “Risk Factors—Risks Related to Employee Matters, Managing Our Growth and Other Risks Related to Our Business—Our business and operations may suffer in the event of information technology system failures, cyberattacks or deficiencies in our cybersecurity.”

Cybersecurity Governance

The Board considers cybersecurity risk as part of its overall risk oversight function and has delegated to the Audit Committee oversight of cybersecurity and information security risks, including oversight of management’s implementation of our cybersecurity risk management program. The Audit Committee receives periodic reports from management regarding our cybersecurity program. These reports include updates on our cybersecurity program and the status of projects to strengthen our information security systems. In addition, management updates the Audit Committee, where it deems appropriate, regarding cybersecurity incidents it considers to be significant. The Audit Committee periodically reports to the full Board regarding its activities, including those related to cybersecurity.

Our management team, including our Chief Executive Officer, our Chief Legal Officer and our Vice President, Information Technology, is responsible for assessing and managing our risks from cybersecurity threats. Certain members of our management team are part of our Cyber Incident Response Team and are responsible for executing the processes set forth therein, including with respect to our key third party service providers. Our Vice President, Information Technology has over thirty years of experience in information security, and previously held a Certified Information Systems Auditor certification from the Information Systems Audit and Control Association from 2006 to 2022. Our Chief Executive Officer has thirty years of experience overseeing information technology, or IT, functions and has eight years of experience serving on the audit committees of companies that had oversight responsibility of the company’s cybersecurity risk management program. Our management team takes steps to stay informed about and monitor efforts to prevent, detect, mitigate and remediate cybersecurity risks and incidents through various means, which may include briefings from internal security personnel; threat intelligence and other information obtained from governmental, public or private sources, including external consultants engaged by us; and alerts and reports produced by security tools deployed in our IT environment.