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Spyre Therapeutics, Inc.

For the period ended Jun 30, 2026. Filed Aug 4, 2026.

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A company's report for each of its first three quarters. The financial statements are not audited. It shows how the business has moved since the last annual report, and what management says changed.

Jun 30, 2026 · Filed Aug 4, 2026

SYRE$103.86+7.5%Stored close · as of Nov 6, 2026

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Item 5. Other Information

Trading Plans

During the fiscal quarter ended June 30, 2026, no director or Section 16 officer adopted orterminated any Rule 10b5-1 trading arrangement or non-Rule 10b5-1 trading arrangement (in each case, as defined in Item 408(a) of Regulation S-K) except as described below.

On April 16, 2026, Heidy King-Jones, our Chief Legal Officer and Corporate Secretary, adopted a trading plan intended to satisfy Rule 10b5-1(c) to sell up to 76,000 shares of our common stock over a period ending April 5, 2028, subject to certain conditions, all of which are to be acquired upon the exercise of employee stock options.

On April 16, 2026, Jeffrey Albers, one of ourdirectors, and Sessions LLC, an investment company of which Mr. Albers is a managing director and owns 10% or more of the equity interest in or otherwise exercises significant influence over, adopted a trading plan intended to satisfy Rule 10b5-1(c) to sell up to 23,000 shares of our common stock over a period ending July 31, 2027, subject to certain conditions,5,000 of which are to be acquired upon the exercise of director stock options.

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