GRAIL, Inc.

Our principal office and research laboratory is approximately 74,300 square feet and located at 1525 O’Brien Drive, Menlo Park, California. We also lease office space of approximately 57,400 square feet at 1605 Adams Drive, Menlo Park, California. These leases expire on September 30, 2026. The Company plans to relocate its headquarters to Sunnyvale, California upon expiration of these leases.

In June 2020, we entered into an agreement to lease approximately 200,000 square feet of a building in Durham, North Carolina which is primarily a commercial laboratory capable of meeting demand of up to one million tests per year. We have approximately 46,000 square feet of CAP-accredited, CLIA-certified laboratory space with sufficient capacity to support multiple years of growth. This lease expires in 2033 and we have three separate options to extend the lease, each for an additional five years. We hold a CLIA Certificate of Accreditation Registration from the CMS,an accreditation from CAP, and certifications from the State of California Department of Public Health and New York State Department of Health, among others, for our North Carolina laboratory.

In September 2025, we entered into an agreement to lease an aggregate of approximately 75,556 square feet for our new corporate headquarters located at 250 S. Matilda Avenue, Suite 100 in Sunnyvale, California. This lease is expected to commence on or about October 1, 2026 and expire on or about September 30, 2037. We have the option to expand into additional space and renew the lease for an additional five-year term under specified conditions.

We believe that our facilities are sufficient to meet our current and anticipated near-term needs.

For financial information regarding leases, refer to Note 9 — Leasesin Item 8 in this Annual Report on Form 10-K.