Twist Bioscience Corp

SCHEDULE 14AINFORMATION

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

Filed by the Registrant x

Filed by a Party other than the Registrant o

Check the appropriate box:

Twist Bioscience Corporation

(Name of Registrant as Specified In Its Charter)

N/A

(Name of Person(s) Filing Proxy Statement if Other Than the Registrant)

Payment of Filing Fee (Check all boxes that apply):

TWIST BIOSCIENCE CORPORATION

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD ONFEBRUARY 5, 2026

You are cordially invited to attend an annual meeting of stockholders (the “Annual Meeting”) of Twist

Bioscience Corporation (the “Company”) that will be held via live audiocast at

www.virtualshareholdermeeting.com/TWST2026 on February 5, 2026 at 7:00 am Pacific Standard Time for the

following purposes:

1. To elect three Class II directors of our Board of Directors to serve for the ensuing three years and until

their successors are elected and qualified or until their earlier resignation or removal;

2. To approve, on a non-binding and advisory basis, a resolution approving the compensation of our

Named Executive Officers, as described in the accompanying proxy statement under “Executive

Compensation”;

3. To ratify the appointment of Ernst & Young LLP as the Company’s independent registered public

accounting firm for the fiscal year ending September 30,2026; and

4. To transact other business that may properly come before the Annual Meeting or any adjournments or

postponements thereof.

You can find more information about each of these items, including the nominees for directors, in the proxy

statement accompanying this notice. The record date for the Annual Meeting is December 26, 2025. Only

stockholders of record at the close of business on that date may vote at the meeting or any postponement or

adjournment thereof. This notice of annual meeting of stockholders and accompanying proxy statement and

form of proxy are first being mailed to stockholders on or about January 6, 2026.

The Board of Directors recommends that you vote in favor of each of the nominees for director (proposal 1)

and in favor of proposals 2 and 3, each as named or outlined in the proxy statement accompanying this notice.

Pursuant to rules promulgated by the Securities and Exchange Commission (“SEC”), we have elected to

provide access to our proxy materials both by sending you this full set of proxy materials, including a proxy

card, and by notifying you of the availability of our proxy materials on the internet. The proxy statement and our

2025 Annual Report to stockholders (the “2025 Annual Report”) are available at www.proxyvote.com.

You are cordially invited to attend the Annual Meeting via live audiocast. Whether or not you expect to

virtually attend the Annual Meeting, please vote on the matters to be considered as promptly as possible in

order to ensure your representation at the meeting. You may vote via the internet, by telephone or by returning

the enclosed proxy card. Even if you have voted by proxy, you may still vote via live audiocast if you virtually

attend the Annual Meeting by going to www.virtualshareholdermeeting.com/TWST2026 and logging in using the

16-digit control number found on your proxy card or voting instruction form. Once you are admitted as a

stockholder to the Annual Meeting, you may vote and ask questions by following the instructions available on

the meeting website. Your proxy is revocable in accordance with the procedures set forth in the proxy

statement.

You are encouraged to log in to www.virtualshareholdermeeting.com/TWST2026 before the Annual Meeting

begins. Online check-in will be available approximately 15 minutes before the meeting starts. If you encounter

any difficulties accessing or participating in the Annual Meeting through the meeting website, please call the

support team at the numbers listed on the website log-in screen.

By order of the Board of Directors,

Emily M. Leproust, Ph.D.

Chief Executive Officer

South San Francisco, California

January 6, 2026

• YOUR VOTE IS IMPORTANT SO PLEASE ACT TODAY! *

IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS

FOR THE ANNUAL MEETING OF STOCKHOLDERS OF TWIST BIOSCIENCE CORPORATION TO BE

HELD ONFEBRUARY 5, 2026

PROXY MATERIALS, INCLUDING OUR 2025 ANNUAL REPORT, ARE AVAILABLE AT

WWW.PROXYVOTE.COM. WHETHER OR NOT YOU PLAN TO ATTEND THE ANNUAL MEETING VIA LIVE

AUDIOCAST, WE ENCOURAGE YOU TO VOTE AND SUBMIT YOUR PROXY BY INTERNET OR BY MAIL.

FOR ADDITIONAL INSTRUCTIONS ON VOTING BY TELEPHONE OR THE INTERNET, PLEASE REFER

TO YOUR PROXY CARD. TO VOTE AND SUBMIT YOUR PROXY BY MAIL, PLEASE COMPLETE, SIGN

AND DATE THE ENCLOSED PROXY CARD AND RETURN IT IN THE ENCLOSED ENVELOPE. IF YOU

ATTEND THE ANNUAL MEETING VIA LIVE AUDIOCAST, YOU MAY REVOKE YOUR PROXY AND VOTE

VIRTUALLY. IF YOU HOLD YOUR SHARES THROUGH AN ACCOUNT WITH A BROKERAGE FIRM, BANK

OR OTHER NOMINEE, PLEASE FOLLOW THE INSTRUCTIONS YOU RECEIVE FROM YOUR ACCOUNT

MANAGER TO VOTE YOUR SHARES.

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