uniQure NV

During the three months ended March 31, 2025, each of the following officers adopted a “Rule 10b5-1 trading arrangement” (as defined in Item 408(a) of Regulation S-K) that is intended to satisfy the affirmative defense of Rule 10b5-1(c) under the Exchange Act and our policies on insider trading:

(1) Date of adoption of this Rule 10b5-1 trading arrangement is in accordance with applicable SEC rules and regulations. The first trade pursuant to this Rule 10b5-1 trading arrangement will be, in accordance with applicable SEC rules and regulations, on a date after the date of adoption of the Rule 10b5-1 trading arrangement, to the extent triggered under its terms.

(2)The Rule 10b5-1 trading arrangement permits transactions through and including the earlier to occur of (a) the completion of all sales or (b) the date listed in the table. The arrangement also provides for automatic expiration in the event of bankruptcy, insolvency, death or mental incapacity of the adopting person.

(3)Sales under the 10b5-1 trading arrangement referred to in the table above for Mr. Kapusta will begin no earlier than (i) August 26, 2025 or (ii) the completion of all sales under Mr. Kapusta’s 10b5-1 trading arrangement dated August 12, 2024 (the terms of which are disclosed in our Quarterly Report on Form 10-Q for the period ended September 30, 2024).

Other than those disclosed above, none of our directors or officers adopted, modified, orterminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” in each case as defined in Item 408 of Regulation S-K, during the three months ended March 31, 2025.