Nurix Therapeutics Inc

(c) Director and Section 16 Officer Rule 10b5-1 Trading Arrangements

On February 29, 2024, Christine Ring, Ph.D., J.D., Chief Legal Officer and Chief Compliance Officer of the Company, entered into a prearranged written stock sale plan (Rule 10b5-1 Plan) in accordance with Rule 10b5-1 under the Securities Exchange Act of 1934, as amended (Exchange Act). The Rule 10b5-1 Plan was entered into during an open trading window in accordance with the Company’s policies regarding transactions in the Company’s securities and is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act. The Rule 10b5-1 Plan provides for the potential sale of an aggregate of up to 111,060 shares of the Company’s common stock issuable upon the exercise of option awards granted to Dr. Ring under the Company’s 2012 Equity Incentive Plan and 2020 Equity Incentive Plan, so long as the market price of the Company’s common stock is higher than certain minimum threshold prices specified in the Rule 10b5-1 Plan. A portion of the shares are expected to be sold in the market to cover the exercise price and taxes associated with the exercise of the options. The remaining shares underlying the options will be sold in the open market at the times and prices specified in the Rule 10b5-1 Plan. The first potential sale date under the Rule 10b5-1 Plan is May 30, 2024. The Rule 10b5-1 Plan expires on February 15, 2025, or upon the earlier completion of all authorized transactions under such Rule 10b5-1 Plan.

The Rule 10b5-1 Plan includes a representation from Ms. Ring to the broker administering the Rule 10b5-1 Plan that she was not in possession of any material nonpublic information regarding the Company or the securities subject to the Rule 10b5-1 Plan at the time it was entered into. A similar representation was made to the Company in connection with the adoption of the Rule 10b5-1 Plan under the Company’s policies regarding transactions in the Company’s securities. Those representations were made as of the date of adoption of the Rule 10b5-1 Plan, and speak only as of such date. In making those representations, there is no assurance with respect to any material nonpublic information of which the insider was unaware, or with respect to any material nonpublic information acquired by the insider or the Company after the date of the representation.

No other director or Section 16 officer of the Company adopted orterminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K, during the three months ended February 29, 2024.