Skye Bioscience, Inc.

Rule 10b5-1 and Non-Rule 10b5-1 Trading Arrangements

On April 24, 2025, Kaitlyn Arsenault, the Company’s Chief Financial Officer, adopted a Rule 10b5-1 trading plan. Ms. Arsenault's Rule 10b5-1 trading plan is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c ) under the Exchange Act ("Rule 10b5-1(c)") and provides for (i) the potential sale of up to 45,434 shares of the Company’s common stock subject to restricted stock units held by Ms. Arsenault until December 31, 2027 and (ii) the sale of an indeterminate number of shares of the Company's common stock at market prices sufficient to cover Ms. Arsenault's tax liability upon the vesting of the unvested restricted stock units held by Ms. Arsenault until December 31, 2027.

On April 25, 2025, Paul Grayson, the Chairman of the Company's Board of Directors, adopted a Rule 10b5-1 trading plan. Mr. Grayson's Rule 10b5-1 trading plan is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) and provides for (i) the potential sale of up to 86,563 shares of the Company’s common stock subject to restricted stock units held by Mr. Grayson until December 31, 2026, which amount includes the sale of an indeterminate number of shares of the Company's common stock at market prices sufficient to cover Mr. Grayson's tax liability upon the vesting of the unvested restricted stock units held by Mr. Grayson until December 31, 2026 and (ii) the potential sale of up to 98,138 shares of the Company’s common stock held by Mr. Grayson until December 31, 2026.

On April 25, 2025, Chris Twitty, the Company’s Chief Scientific Officer, adopted a Rule 10b5-1 trading plan. Dr. Twitty's Rule 10b5-1 trading plan is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) and provides for the sale of an indeterminate number of shares of the Company's common stock at market prices sufficient to cover Dr. Twitty's tax liability upon the vesting of the unvested restricted stock units held by Dr. Twitty until December 31, 2026.

On April 29, 2025, Tu Diep, the Company’s Chief Operating Officer, adopted a Rule 10b5-1 trading plan. Mr. Diep's Rule 10b5-1 trading plan is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) and provides for the sale of an indeterminate number of shares of the Company's common stock at market prices sufficient to cover Mr. Diep's tax liability upon the vesting of the unvested restricted stock units held by Mr. Diep until December 31, 2026.

No other officers or directors, as defined in Rule 16a‐1 (f) under the Exchange Act, adopted and/or terminated a "Rule 10b5‐1 trading arrangement" or a "non‐Rule 10b5‐1 trading arrangement," as defined in Regulation S‐K Item 408, during the last fiscal quarter.