Skye Bioscience, Inc.

Rule 10b5-1 and Non-Rule 10b5-1 Trading Arrangements

On February 12, 2025, Deborah Charych, amember of the Company's Board of Directors, adopted a Rule 10b5-1 trading plan. Dr. Charych's Rule 10b5-1 trading plan is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) and provides for the potential sale of up to 58,917 shares of the Company’s common stock subject to stock options held by Dr. Charych upon exercise of such stock options until December 31, 2025.

On March 28, 2025, Punit Dhillon, the Company’s Chief Executive officer and a member of the Company's Board of Directors, adopted a Rule 10b5-1 trading plan. Mr. Dhillon's Rule 10b5-1 trading plan is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) and provides for (i) the potential sale of up to 68,846 shares of the Company’s common stock subject to restricted stock units held by Mr. Dhillon until December 31, 2025, which amount includes the sale of an indeterminate number of shares of the Company's common stock at market prices sufficient to cover Mr. Dhillon's tax liability upon the vesting of such restricted stock units (ii) the potential sale of up to 25,000 shares of the Company’s common stock subject to restricted stock units held by Mr. Dhillon until December 31, 2026, which amount includes of the sale of an indeterminate number of shares of the Company's common stock at market prices sufficient to cover Mr. Dhillon's tax liability upon the vesting of such restricted stock units, (iii) the potential sale of up to 20,322 shares of the Company’s common stock held by Mr. Dhillon until December 31, 2025 and (iv) the potential sale of up to 50,000 shares of the Company’s common stock held by Mr. Dhillon until December 31, 2026.