Biofrontera Inc.

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 14A INFORMATION

PROXY STATEMENT

PURSUANT TO SECTION 14(a) OF THE

SECURITIES EXCHANGE ACT OF 1934

Filed by the Registrant ☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:

BIOFRONTERA INC.

(Name of Registrant as Specified in Its Charter)

(Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (check the appropriate box):

660 Main Street, 1 st Floor

Woburn, Massachusetts 01801

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To Be Held on June 11, 2026

Dear Stockholder of Biofrontera Inc.:

NOTICE IS HEREBY GIVEN that the 2026 Annual Meeting of Stockholders (the “Meeting”) of Biofrontera Inc., a Delaware corporation (the “Company”), will be held on June 11, 2026, at 10:00 a.m., Eastern Time. The meeting will be completely virtual and will be conducted solely online via live webcast. There will not be a physical location for the Meeting.

You will be able to attend the Meeting virtually and to vote and submit questions prior to and during the Meeting by visiting meetnow.global/MVWJYNQ and entering the control number provided in the Notice of Internet Availability of Proxy Materials (or proxy card, if you request and receive a physical copy of the proxy materials).

At the Meeting, stockholders will be asked to vote on the following matters:

The matters listed above are described in the accompanying Proxy Statement. The Board of Directors has fixed the close of business on April 21, 2026 as the record date for determining the stockholders entitled to notice of and to vote at the Meeting or any adjournments or postponements. The list of stockholders of record as of the record date will be made available for inspection at the Meeting and will also be available for inspection during the ten days preceding the Meeting at the Company’s offices located at 660 Main Street, 1 st Floor, Woburn, Massachusetts 01801. We are distributing proxy materials online rather than mailing printed copies, as it allows us to expedite delivery to our stockholders through a lower cost, more environmentally responsible method. You will not receive printed copies unless you request them by following the instructions contained in the Notice of Internet Availability of Proxy Materials that you previously received.

YOUR VOTE IS IMPORTANT. WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING, PLEASE PROVIDE US WITH YOUR VOTING INSTRUCTIONS IN ONE OF THE FOLLOWING WAYS AS PROMPTLY AS POSSIBLE:

By internet or telephone. To vote your shares via the internet, go to www.investorvote.com/BFRI to complete an electronic proxy card. If you vote by telephone, call 1-800-652-8683 in the United States, U.S. territories and Canada and follow the instructions. You will be asked to provide the Company number and control number from the Notice of Internet Availability of Proxy Materials (or proxy card, if you request and receive a physical copy of the proxy materials).

By mail. If you request and receive a paper copy of a proxy card by mail, you may vote by mail. To have your shares voted using the proxy card, simply complete, sign and date the proxy card and return it promptly in the envelope provided.

On behalf of the Board of Directors and the employees of Biofrontera Inc., we thank you for your continued support.

April 30, 2026

IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS FOR THE 2026 ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON JUNE 11, 2026: THE COMPANY’S PROXY MATERIALS AND ANNUAL REPORT ARE AVAILABLE AT http://www.edocumentview.com/BFRI.

660 Main Street, 1 st Floor

Woburn, Massachusetts 01801

PROXY STATEMENT

For the 2026 Annual Meeting of Stockholders to be held on June 11, 2026

The Company is providing this Proxy Statement in connection with the solicitation by its Board of Directors (the “Board”) of proxies to be voted at the 2026 Annual Meeting, to be held on June 11, 2026, at 10:00 a.m., Eastern Time, in a virtual-only format, and any adjournments or postponements.

Only stockholders as of the record date of April 21, 2026 may attend the Meeting. At the close of business on the record date, we had outstanding 12,007,558 shares of our common stock, par value $0.001 per share (the “Common Stock”), representing a total of 12,007,558 votes entitled to be cast at the Meeting, and 22,286 shares of our preferred stock, par value $0.001 per share (the “Preferred Stock”), representing a total of 4,742,525 votes entitled to be cast at the Meeting. We made our proxy materials available to stockholders on or about May 1, 2026. Our proxy materials include the Notice of the Annual Meeting, this Proxy Statement, and the proxy card. These proxy materials, other than the proxy card, which is available only with the printed materials, along with our Annual Report on Form 10-K for the year ended December 31, 2025, can be accessed at http://www.edocumentview.com/BFRI.

You are invited to attend the Meeting to vote on the proposals described in this Proxy Statement. However, you do not need to attend the Meeting to vote your shares. Instead, you may vote by following the instructions under “Questions and Answers” below. The matters to be acted on are stated in the accompanying Notice of Annual Meeting of Stockholders. The Board knows of no other business to come before the Meeting.

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