Schrodinger, Inc.

For the period ended Dec 31, 2025. Filed Feb 25, 2026.

About this filing

A company's yearly report to the SEC, with audited financial statements. It is the fullest account a company gives of its business, its finances and the risks it sees.

FY2025 · Filed Feb 25, 2026

SDGR$32.41-2.9%Stored close · as of Nov 10, 2026

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Contents

Item 15. Exhibits and Financial Statement Schedules

(1)Financial Statements

The following documents are included in the pages herein and are filed as part of this Annual Report.

	Page
Reports of Independent Registered Public Accounting Firm	F-2
Consolidated Balance Sheets as of December 31, 2025 and 2024	F-4
Consolidated Statements of Operations for the Years ended December 31, 2025, 2024, and 2023	F-5
Consolidated Statements of Comprehensive (Loss) Income for the Years ended December 31, 2025, 2024, and 2023	F-6
Consolidated Statements of Stockholders’ Equity for the Years ended December 31, 2025, 2024, and 2023	F-7
Consolidated Statements of Cash Flows for the Years ended December 31, 2025, 2024, and 2023	F-8
Notes to Consolidated Financial Statements	F-9

(2)Financial Statement Schedules

All financial statement schedules have been omitted because they are not applicable, not required, or the information required is shown in the consolidated financial statements or the notes thereto.

(3)Exhibits

The exhibits filed as part of this Annual Report are listed below.

ExhibitNumber · Description of Exhibit · Form · File No. · Exhibit · Filing Date · Filed Herewith
3.1	Restated Certificate of Incorporation, as amended	10-Q	001-39206	3.1	7/31/2024
3.2	Amended and Restated Bylaws of Schrödinger, Inc.	8-K	001-39206	3.1	4/13/2023
4.1	Specimen Stock Certificate evidencing the shares of common stock	S-1/A	333-235890	4.1	1/27/2020
4.2	Amended and Restated Share Exchange Agreement, dated January 24, 2020, by and between the Registrant and Bill & Melinda Gates Foundation Trust	S-1/A	333-235890	4.2	1/27/2020
4.3	Description of Securities Registered Under Section 12 of the Exchange Act	10-K	001-39206	4.3	3/4/2021
10.1	Amended and Restated Investors’ Rights Agreement, dated as of November 9, 2018, by and among the Registrant and the other parties thereto, as amended	10-K	001-39206	10.1	2/28/2024
10.2+	2010 Stock Plan, as amended	S-1	333-235890	10.2	1/10/2020
10.3+	Form of Notice of Stock Option Grant and Stock Option Agreement under 2010 Stock Plan	S-1	333-235890	10.3	1/10/2020
10.4+	2020 Equity Incentive Plan	S-1/A	333-235890	10.4	1/27/2020
10.5+	Form of Stock Option Agreement and Form of Restricted Stock Unit Agreement for U.S. Participants under the 2020 Equity Incentive Plan	10-K	001-39206	10.5	2/24/2022
10.6+	Form of Stock Option Agreement for Non-U.S. Participants under the 2020 Equity Incentive Plan	10-Q	001-39206	10.2	11/12/2020

10.7+	Form of Restricted Stock Unit Agreement for Non-U.S. Participants under the 2020 Equity Incentive Plan	10-K	001-39206	10.6	2/24/2022
10.8+	2020 Employee Stock Purchase Plan, as amended	10-Q	001-39206	10.4	7/31/2024
10.9+	Seventh Amended and Restated Director Compensation Policy	10-Q	001-39206	10.1	8/6/2025
10.10+	Senior Executive Incentive Compensation Plan	S-1	333-235890	10.8	1/10/2020
10.11+	Amended and Restated Executive Severance and Change in Control Benefits Plan, as amended	8-K	001-39206	10.2	8/18/2022
10.12+	Employment Agreement, dated May 11, 2010, by and between the Registrant and Ramy Farid	S-1	333-235890	10.1	1/10/2020
10.13+	Employment Agreement, dated May 16, 2025, by and between Schrödinger, Inc. and Richie Jain	8-K	001-39206	10.1	5/20/2025
10.14+	Employment Agreement, dated August 16, 2022, by and between the Registrant and Geoffrey Porges	8-K	001-39206	10.1	8/18/2022
10.15+	Separation and Release of Claims Agreement, dated as of September 5, 2025, by and between the Registrant and Geoffrey Porges	8-K	001-39206	10.1	9/8/2025
10.16+	Employment Agreement, dated March 17, 2003, by and between the Registrant and Jenny Herman	10-K	001-39206	10.15	2/28/2023
10.17+	Employment Agreement, dated May 14, 2018, by and between the Registrant and Karen Akinsanya	S-1	333-235890	10.14	1/10/2020
10.18+	Employment Agreement, dated April 27, 2010, by and between the Registrant and Yvonne Tran	S-1	333-235890	10.16	1/10/2020
10.19+	Employment Agreement, dated September 11, 2006, by and between the Registrant and Patrick Lorton	S-1	333-235890	10.17	1/10/2020
10.20+	Employment Agreement, dated March 9, 2009, by and between the Registrant and Robert Abel	S-1	333-235890	10.19	1/10/2020
10.21†+	Employment Agreement, dated May 9, 2025, by and between the Registrant and Mannix Aklian					X
10.22+	Employment Agreement, dated July 28, 2023, by and between the Registrant and Margaret Dugan	10-K	001-39206	10.19	2/28/2024
10.23+	Consulting Agreement, dated December 1, 2025, by and between the Registrant and Dugan Consulting, LLC					X
10.24+	Consultant Agreement, dated July 1, 1999, between the Registrant and Richard A. Friesner, as amended					X
10.25+	Form of Indemnification Agreement between the Registrant and each of its Executive Officers and Directors	S-1	333-235890	10.21	1/10/2020
10.26	Office Lease Agreement, dated April 5, 2021, by and between the Registrant and SPUSV5 1540 Broadway, LLC	8-K	001-39206	10.1	4/8/2021
10.27	First Amendment to Lease, dated May 19, 2022, by and between the Registrant and SPUSV5 1540 Broadway, LLC	10-Q	001-39206	10.1	8/4/2022
10.28	Second Amendment to Lease, dated June 13, 2024, by and between the Registrant and SPUSV5 1540 Broadway, LLC	10-Q	001-39206	10.2	7/31/2024

10.29	Lease, dated August 6, 2008, between One Main Place Portland – Oregon, Inc., Landlord, and Registrant, Tenant, as amended	S-1	333-235890	10.23	1/10/2020
10.30	Office Lease Amendment, dated May 6, 2021, by and between Registrant and MADISON-OFC ONE MAIN PLACE OR LLC	10-Q	001-39206	10.2	8/12/2021
10.31†	Agreement, dated as of May 5, 1994, between The Trustees of Columbia University in the City of New York and Registrant, as amended	S-1	333-235890	10.24	1/10/2020
10.32†	Agreement, dated as of July 15, 1998, between The Trustees of Columbia University in the City of New York and Registrant, as amended	S-1	333-235890	10.25	1/10/2020
10.33†	Agreement, dated as of September 2001, between The Trustees of Columbia University in the City of New York and Schrödinger, LLC, as amended	S-1	333-235890	10.26	1/10/2020
10.34†	Agreement, dated as of June 19, 2003, between The Trustees of Columbia University in the City of New York and Schrödinger, LLC	S-1	333-235890	10.27	1/10/2020
10.35†	Software and Patent License Agreement, dated May 27, 2008, between The Trustees of Columbia University in the City of New York and Schrödinger, LLC	S-1	333-235890	10.28	1/10/2020
10.36†	Services Royalty Amendment, dated November 1, 2008, by and between The Trustees of Columbia University in the City of New York and Schrödinger, LLC	S-1	333-235890	10.29	1/10/2020
10.37†	Master License Agreement, dated as of September 11, 2024, by and between Schrödinger, LLC and The Trustees of Columbia University	8-K	001-39206	10.1	9/12/2024
10.38+	Global Bonus Plan	S-1/A	333-235890	10.33	1/27/2020
10.39†	Independent Contractor Agreement, dated June 23, 2020, by and between the Registrant and Gates Ventures, LLC	10-Q	001-39206	10.2	8/10/2020
10.40†	Amendment #1 to the Independent Contractor Agreement, dated August 14, 2023, by and between the Registrant and Gates Ventures, LLC	10-Q	001-39206	10.1	11/1/2023
10.41+	2021 Inducement Equity Incentive Plan, as amended	S-8	333-287037	99.1	5/7/2025
10.42+	Nonstatutory Stock Option Agreement under 2021 Inducement Equity Incentive Plan	10-K	001-39206	10.39	3/4/2021
10.43+	Form of Option Agreement for Non-U.S. Participants under the 2021 Inducement Equity Incentive Plan	10-Q	001-39206	10.3	8/4/2022
10.44+	Form of Restricted Stock Unit Agreement for U.S. Participants under 2021 Inducement Equity Incentive Plan	10-Q	001-39206	10.1	5/4/2023
10.45+	Form of Restricted Stock Unit Agreement for Non-U.S. Participants under 2021 Inducement Equity Incentive Plan	10-Q	001-39206	10.2	5/4/2023
10.46+	Schrödinger, Inc. 2022 Equity Incentive Plan, as amended	10-Q	001-39206	10.3	7/31/2024
10.47+	Form of Option Agreement for U.S. Participants under the 2022 Equity Incentive Plan	10-Q	001-39206	10.4	8/4/2022

10.48+	Form of Option Agreement for Non-U.S. Participants under the 2022 Equity Incentive Plan	10-Q	001-39206	10.5	8/4/2022
10.49+	Form of Restricted Stock Unit Agreement for U.S. Participants under the 2022 Equity Incentive Plan	10-Q	001-39206	10.6	8/4/2022
10.50+	Form of Restricted Stock Unit Agreement for Non-U.S. Participants under the 2022 Equity Incentive Plan	10-Q	001-39206	10.7	8/4/2022
10.51+	Amended and Restated Sales Agreement, dated as of February 28, 2024, by and between the Registrant and Leerink Partners LLC.	8-K	001-39206	1.1	2/29/2024
10.52†	Research Collaboration and License Agreement, dated as of November 11, 2024, by and between the Registrant and Novartis Pharma AG	10-K	001-39206	10.48	2/26/2025
19.1	Schrödinger, Inc. Global Insider Trading Policy	10-K	001-39206	19.1	2/26/2025
21.1	Subsidiaries of the Registrant					X
23.1	Consent of KPMG LLP, independent registered public accounting firm					X
31.1	Certification of Principal Executive Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002					X
31.2	Certification of Principal Financial Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002					X
32.1#	Certification of Principal Executive Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002					X
32.2#	Certification of Principal Financial Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002					X
97.1+	Schrödinger, Inc. Clawback Policy	10-K	001-39206	97.1	2/28/2024
101.INS	Inline XBRL Instance Document – the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document.					X
101.SCH	Inline XBRL Taxonomy Extension Schema Document.					X
101.CAL	Inline XBRL Taxonomy Extension Calculation Linkbase Document					X
101.DEF	Inline XBRL Taxonomy Extension Definition Linkbase Document.					X
101.LAB	Inline XBRL Taxonomy Extension Label Linkbase Document.					X

101.PRE	Inline XBRL Taxonomy Extension Presentation Linkbase Document	X
104	Cover page formatted as Inline XBRL and contained in Exhibit 101.	X

†	Portions of this exhibit have been omitted pursuant to Item 601(b)(10)(iv) of Regulation S-K.
#	The certifications attached as Exhibits 32.1 and 32.2 that accompany this Annual Report, are deemed furnished and not filed with the Securities and Exchange Commission and are not to be incorporated by reference into any filing of Schrödinger, Inc. under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date of this Annual Report, irrespective of any general incorporation language contained in such filing.
+	Management contract or compensatory plan or arrangement filed in response to Item 15(a)(3) of the Instructions to the Annual Report on Form 10-K.

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