Contineum Therapeutics, Inc.

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of

the Securities Exchange Act of 1934 (Amendment No. )

Filed by the Registrant ☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:

Contineum Therapeutics, Inc.

(Name of Registrant as Specified in its Charter)

(Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box):

To the Stockholders of Contineum Therapeutics, Inc.:

It is my pleasure to invite you to attend the 2025 Annual Meeting of Stockholders (the “Annual Meeting”) of Contineum Therapeutics, Inc., to be held on Thursday, June 26, 2025 at 9:00 a.m. (Pacific Time).The Annual Meeting will be completely virtual. You may attend the virtual meeting, submit questions, and vote your shares electronically during the meeting via live webcast by registering at www.proxydocs.com/CTNM in advance of the Annual Meeting. Upon completing your registration, you will receive further instructions via email, including a unique link that will allow you access to the Annual Meeting and to vote and submit questions during the Annual Meeting.

Details regarding the business to be conducted at the Annual Meeting are more fully described in the accompanying Notice of Annual Meeting of Stockholders and Proxy Statement.

We are permitted by the Securities and Exchange Commission rules that allow companies to furnish proxy materials to their stockholders on the internet. On or around Tuesday, April 29, 2025, we expect to mail to our stockholders of record an Important Notice Regarding Internet Availability of Proxy Materials (the “Notice”) containing instructions on how to access our proxy statement for our Annual Meeting (the “Proxy Statement”) and our 2024 Annual Report on Form 10-K. The Notice also provides instructions on how to vote online or by telephone, how to access the virtual Annual Meeting, and how to receive a paper copy of the proxy materials by mail.

Whether or not you plan to virtually attend the meeting, your vote is important and we encourage you to vote promptly. You may vote by proxy over the internet or by telephone, or, if you received paper copies of the proxy materials by mail, you can also vote by mail by following the instructions on your proxy card. If you virtually attend the Annual Meeting, you will have the right to revoke your proxy and vote electronically during the Annual Meeting via the live webcast. If you hold your shares through an account with a brokerage firm, bank or other nominee, please follow the instructions you receive from your brokerage firm, bank or other nominee to vote your shares.

On behalf of the Board of Directors, thank you for your continued support.

Sincerely,

/s/ Carmine N. Stengone Carmine N. Stengone President, Chief Executive Officer and Director

3565 General Atomics Court, Suite 200 San Diego, CA 92121

Telephone: 858-333-5280 www.contineum-tx.com

Contineum Therapeutics, Inc.

3565 General Atomics Court, Suite 200

San Diego, CA 92121

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To be held virtually at 9:00 a.m., Pacific Time, on Thursday, June 26, 2025

To the Stockholders of Contineum Therapeutics, Inc.:

You are cordially invited to attend the Annual Meeting of Stockholders (the “Annual Meeting”) of Contineum Therapeutics, Inc., a Delaware corporation. The meeting will be held on Thursday, June 26, 2025, at 9:00 a.m. (Pacific Time).The Annual Meeting will be completely virtual. You may attend the meeting, submit questions, and vote your shares electronically during the meeting via live webcast by registering at***www.proxydocs.com/CTNM**** *in advance of the Annual Meeting. You do not need to attend the virtual Annual Meeting to vote your shares. Instead, you may vote by internet, by telephone, or, if you requested and received paper copies of the proxy materials by mail, you may also vote by completing and mailing your proxy card. Upon completing your registration, you will receive further instructions via email, including a unique link that will allow you access to the Annual Meeting and to vote and submit questions during the Annual Meeting. At the Annual Meeting our stockholders will be asked:

These items of business are more fully described in the Proxy Statement accompanying this Notice.

The record date for the Annual Meeting is April 28, 2025. Only stockholders of record at the close of business on that date may vote at the Annual Meeting or any adjournment thereof.

Our Board of Directors recommends a vote “FOR” for the election of all nominees for director to our Board of Directors and “FOR” the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2025.

Regardless of the number of shares you own, your VOTE is important. Therefore, even if you presently plan to virtually attend the Annual Meeting, please vote or submit your proxy by following the instructions in the Important Notice Regarding Internet Availability of Proxy Materials as soon as possible so that your shares can be voted at the Annual Meeting in accordance with your instructions. Telephone and internet voting are available. For specific instructions on voting, please refer to the instructions in the Notice Regarding Internet Availability of Proxy Materials or the proxy card (if you requested and received a printed copy of the proxy materials). If you do virtually attend the Annual Meeting and wish to vote electronically, you may withdraw your proxy at that time.

Please read the attached Proxy Statement, as it contains important information you need to know to vote at the Annual Meeting.

By Order of our Board of Directors

/s/ Carmine N. Stengone

Carmine N. Stengone President, Chief Executive Officer and Director

San Diego, California

You are cordially invited to attend the virtual Annual Meeting. Whether or not you expect to attend the virtual Annual Meeting, please vote as soon as possible. We encourage you to vote via the internet. For further details, see “Questions and Answers about This Proxy Material and Voting.”

Contineum Therapeutics, Inc.

3565 General Atomics Court, Suite 200

San Diego, CA 92121

FOR THE 2025 ANNUAL MEETING OF STOCKHOLDERS

To be held virtually at 9:00 a.m., Pacific Time, on Thursday, June 26, 2025

This proxy statement and proxy card are furnished in connection with the solicitation of proxies by our Board of Directors to be voted at the 2025 Annual Meeting of Stockholders (the “Annual Meeting”) of Contineum Therapeutics, Inc. (sometimes referred to as “we,” “us,” “or,” the “Company” or “Contineum”), which will be held virtually on Thursday, June 26, 2025, at 9:00 a.m. (Pacific Time) via live webcast. To attend the Annual Meeting, stockholders of record must register atwww.proxydocs.com/CTNMin advance of the Annual Meeting. Upon completing your registration, you will receive further instructions via email, including a unique link that will allow you access to the Annual Meeting and to vote and submit questions during the Annual Meeting. However, you do not need to attend the virtual Annual Meeting to vote your shares. Instead, you may vote by internet, by telephone, or, if you requested and received paper copies of the proxy materials by mail, you may also vote by completing and mailing your proxy card.

IMPORTANT NOTICE REGARDING INTERNET AVAILABILITY OF PROXY MATERIALS

We are making this proxy statement and our annual report available to stockholders primarily via the internet, instead of mailing printed copies of those materials to each stockholder. This proxy statement, the Notice of Annual Meeting of Stockholders, our form of proxy card and our Annual Report on Form 10-K for the year ended December 31, 2024 (the “Annual Report on Form 10-K”) are available for viewing, downloading and printing atwww.proxydocs.com/CTNM. On or around Tuesday, April 29, 2025, we intend to mail to our stockholders the Notice Regarding Availability of Proxy Materials (the “Notice”) containing instructions on how to access and review this proxy statement and our Annual Report on Form 10-K. The Notice also includes instructions on how you may submit your proxy over the internet or via telephone and how to vote online at the Annual Meeting. If you received a Notice and would like to receive a printed copy of our proxy materials, you should follow the instructions for requesting those materials included in the Notice.

Additionally, you can find a copy of our Annual Report on Form 10-K, which includes our financial statements for the fiscal year ended December 31, 2024, on the website of the Securities and Exchange Commission (“SEC”), atwww.sec.gov, or in the “SEC Filings” section of the “Investors” section of our website located atwww.contineum-tx.com. You may also obtain a copy of our Annual Report on Form 10-K, including our financial statements, free of charge, by sending a written request to the attention of our Corporate Secretary at Contineum Therapeutics, Inc., 3565 General Atomics Court, Suite 200, San Diego, CA 92121.