Upstream Bio, Inc.

For the period ended Mar 31, 2026. Filed May 13, 2026.

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A company's report for each of its first three quarters. The financial statements are not audited. It shows how the business has moved since the last annual report, and what management says changed.

Mar 31, 2026 · Filed May 13, 2026

UPB$3.58+10.8%Stored close · as of Nov 9, 2026

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Contents

Signatures

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	UPSTREAM BIO, INC.
Date: May 13, 2026	By:	/s/ E. Rand Sutherland
		E. Rand Sutherland
		Chief Executive Officer(Principal Executive Officer)
Date: May 13, 2026	By:	/s/ Michael Paul Gray
		Michael Paul Gray
		Chief Financial and Operating Officer(Principal Financial and Accounting Officer)

ContentsView on SEC.gov

The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.