Upstream Bio, Inc.
For the period ended Mar 31, 2026. Filed May 13, 2026.
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A company's report for each of its first three quarters. The financial statements are not audited. It shows how the business has moved since the last annual report, and what management says changed.
Mar 31, 2026 · Filed May 13, 2026
UPB$3.38-5.6%Stored close · as of Nov 10, 2026
Extracted filing text, with the paragraph anchors used by the comparison.
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Condensed Consolidated Statements of Operations and Comprehensive Loss
(Amounts in thousands, except share and per share amounts)
| Three Months Ended March 31, | ||
|---|---|---|
| 2026 | 2025 | |
| Collaboration revenue | $1,034 | $566 |
| Operating expenses: | ||
| Research and development | 36,565 | 25,797 |
| General and administrative | 8,084 | 6,782 |
| Total operating expenses | 44,649 | 32,579 |
| Loss from operations | (43,615) | (32,013) |
| Other income (expense): | ||
| Interest income | 3,054 | 4,743 |
| Other expense, net | (30) | — |
| Total other income, net | 3,024 | 4,743 |
| Net loss | $(40,591) | $(27,270) |
| Net loss per share attributable to common stockholders, basic and diluted | $(0.75) | $(0.51) |
| Weighted-average common shares outstanding, basic and diluted | 54,332,319 | 53,617,723 |
| Comprehensive loss: | ||
| Net loss | $(40,591) | $(27,270) |
| Unrealized gain (loss) on investments, net of tax | (430) | 393 |
| Total other comprehensive income (loss) | (430) | 393 |
| Comprehensive loss | $(41,021) | $(26,877) |
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