Tempus AI, Inc.

Disclosure of Trading Arrangements

During the fiscal quarter ended March 31, 2026, none of our directors or officers (as defined in Rule 16a-1(f) under the Exchange Act)adopted or terminated a “Rule 10b5-1 trading arrangement” or a “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408 of Regulation S-K, except as set forth in the table below.

• Contract, instruction or written plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act.

** “Non-Rule 10b5-1 trading arrangement” as defined in Item 408(c) of Regulation S-K under the Exchange Act.

(1)

This Rule 10b5-1 trading plan provides for sales of (i) 20,562 shares of Class A common stock and (ii) up to 100% of the net number of shares received upon vesting of an aggregate of 47,180 RSUs and time-vesting PSUs, after giving effect to the withholding or sale of a portion of such shares to satisfy tax withholding obligations. Accordingly, the aggregate maximum number of shares that may be sold pursuant to this trading arrangement is dependent on the amount of tax withholding required upon the vesting of RSUs and time-vesting PSUs, and, therefore, is indeterminable at this time.

(2)

Trading under this Rule 10b5-1 trading plan will not commence until completion of the required cooling off period under Rule 10b5-1 and the conclusion of Mr. Lefkofsky’s prior Rule 10b5-1 trading plan.

(3)

Represents the adoption of a Rule 10b5-1 trading plan by Blue Media, LLC and Gray Media, LLC, each an entity controlled by Mr. Lefkofsky, and Lefkofsky Family Foundation and Vas.org Foundation, of each of which Mr. Lefkofsky is a trustee, providing for the sale of up to 4,590,000 shares of Class A common stock held by Blue Media, LLC, up to 1,955,000 shares of Class A common stock held by Gray Media, LLC, up to 255,000 shares of Class A common stock held by Lefkofsky Family Foundation, and up to 250,000 shares of Class A common stock held by Vas.org Foundation.