MapLight Therapeutics, Inc.

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

Filed by the Registrant ☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:

MapLight Therapeutics, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement if Other Than the Registrant)

Payment of Filing Fee (Check all boxes that apply)

MAPLIGHT THERAPEUTICS, INC.

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To Be Held On June 23, 2026

Dear Stockholder:

You are cordially invited to attend the 2026 Annual Meeting of Stockholders (the “Annual Meeting”) of MapLight Therapeutics, Inc. (the “Company”). The Annual Meeting will be held virtually on Tuesday, June 23, 2026 at 9:00 a.m. Pacific Time.

The Annual Meeting will be held for the following purposes, as more fully described in the accompanying proxy statement (the “Proxy Statement”):

We have elected to provide access to our proxy materials over the internet pursuant to the Securities and Exchange Commission’s “Notice and Access” rule. On or about May 1, 2026, we expect to mail to our stockholders a Notice of Internet Availability of Proxy Materials (the “Notice”) that will indicate how to access our accompanying proxy statement and our annual report for the fiscal year ended December 31, 2025 (the “Annual Report”) through the internet and will include instructions on how you can receive a paper copy of the annual meeting materials, including the Proxy Statement, the Annual Report and a proxy card.

The Board of Directors has fixed April 27, 2026 as the record date for the Annual Meeting. Only stockholders of record at the close of business on that date are entitled to notice of, and to vote at, the Annual Meeting or any adjournment or postponement thereof. You will be able to attend the Annual Meeting, submit your questions and vote online during the meeting by visiting www.proxydocs.com/MPLT and entering the 12-digit control number included in your Notice or in the instructions that you received via email. Please refer to the additional logistical details and recommendations in the Proxy Statement.

By Order of the Board of Directors,

Kristopher L. Hanson

General Counsel and Secretary

Redwood City, California

April 29, 2026

Your vote is important. Whether or not you expect to attend the Annual Meeting, please vote over the internet at www.proxydocs.com/MPLT, over the telephone by calling the toll-free number 1-866-625-6175, or, if you receive a paper proxy card by mail, by completing and returning the proxy mailed to you as promptly as possible in order to ensure your representation at the meeting. Even if you have voted by proxy, you may still vote online if you attend the Annual Meeting. Please note, however, that if your shares are held of record by a broker, bank or other agent and you wish to vote at the Annual Meeting, you must obtain a proxy issued in your name from that record holder.