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ALX ONCOLOGY HOLDINGS INC

For the period ended Apr 17, 2026. Filed Apr 20, 2026.

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What shareholders are asked to vote on at a company's meeting. It is where to find what directors and top executives are paid, and who owns the most shares.

Apr 17, 2026 · Filed Apr 20, 2026

Use the contents to explore the available documents and sections.

ALXO$1.16+0.4%Stored close · as of Nov 6, 2026
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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE

SECURITIES EXCHANGE ACT OF 1934

Filed by the Registrant☒

Filed by a party other than the Registrant☐

Check the appropriate box:

☐Preliminary Proxy Statement
☐Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
☒Definitive Proxy Statement
☐Definitive Additional Materials
☐Soliciting Material Pursuant to §240.14a-11(c) or §240.14a-2

(Name of Registrant as Specified In Its Charter)

Payment of Filing Fee (Check all boxes that apply):

☒No fee required.
☐Fee paid previously with preliminary materials.
☐Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11

Dear Stockholder:

We are pleased to invite you to attend the 2026 Annual Meeting of Stockholders (the Annual Meeting) of ALX Oncology Holdings Inc. (ALX or the Company), which will be conducted via a live webcast on Wednesday, June 10, 2026 at 1:00 p.m. Pacific Time. The Annual Meeting will be held in a virtual format only. You will be able to attend the Annual Meeting by visiting www.virtualshareholdermeeting.com/ALXO2026, where you will be able to listen to the meeting live, submit questions and vote online by entering the control number located on your proxy card.

The attached Notice of Annual Meeting of Stockholders and Proxy Statement contain details of the business to be conducted at the Annual Meeting.

Whether or not you attend the virtual Annual Meeting, it is important that your shares be represented and voted at the meeting. Therefore, we urge you to promptly vote and submit your proxy via the Internet, by phone, or by signing, dating and returning the enclosed proxy card in the enclosed envelope. If you decide to attend the Annual Meeting, you will be able to change your vote or revoke your proxy, even if you have previously submitted your proxy.

On behalf of the Company’s Board of Directors, we would like to thank you for your continued support of and interest in ALX.

Sincerely,

Corey Goodman, Ph.D.Jason Lettmann
Chairman of the Board of DirectorsChief Executive Officer and Director

ALX ONCOLOGY HOLDINGS INC.

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

Time and DateWednesday, June 10, 2026 at 1:00 p.m. Pacific Time
PlaceThe Annual Meeting will be a completely virtual meeting of stockholders, to be conducted via a live webcast. You will be able to attend the Annual Meeting virtually, submit questions and vote online during the meeting by visiting www.virtualshareholdermeeting.com/ALXO2026.
Items of Business•To elect three Class III directors to serve until the 2029 annual meeting of stockholders or until their successors are duly elected and qualified;•To conduct an advisory vote to approve the compensation of our named executive officers (NEOs);•To ratify the appointment of KPMG LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2026; and•To transact such other business as may properly come before the Annual Meeting or any adjournments or postponements thereof.
Record DateWednesday, April 15, 2026 (the Record Date). Only stockholders of record at the close of business on the Record Date are entitled to receive notice of, and to vote at, the Annual Meeting.

YOUR VOTE IS IMPORTANT. Whether or not you plan to attend the Annual Meeting virtually, we urge you to submit your vote via the Internet, telephone or mail as soon as possible to ensure your shares are represented. For additional instructions for each of these voting options, please refer to the proxy card. Returning the proxy does not deprive you of your right to attend the Annual Meeting and to vote your shares at the Annual Meeting. The proxy statement explains proxy voting and the matters to be voted on in more detail.

Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting to Be Held on June 10, 2026. Our proxy statement and Annual Report to Stockholders are being made available on or about April 20, 2026 on our investor relations website at https://ir.alxoncology.com/ under “Financials & Filings.” We are providing access to our proxy materials over the Internet under the rules adopted by the Securities and Exchange Commission.

By order of the Board of Directors,

Jason Lettmann

Chief Executive Officer and Director

South San Francisco, California

This proxy statement is being mailed to stockholders on or about April 20, 2026.

TABLE OF CONTENTS

Page
QUESTIONS AND ANSWERS ABOUT THE ANNUAL MEETING1
BOARD OF DIRECTORS AND CORPORATE GOVERNANCE9
Director Nominees9
Continuing Directors11
Family Relationships12
Director Independence12
Board Leadership Structure13
Board Diversity13
Role of the Board in Risk Oversight13
Committees of our Board of Directors14
Attendance at Board and Stockholder Meetings16
Considerations in Evaluating Director Nominees16
Stockholder Recommendations for Nominations to the Board of Directors17
Communications with the Board of Directors17
Corporate Governance Guidelines and Code of Business Conduct and Ethics17
Director Compensation18
PROPOSAL NO. 1 ELECTION OF DIRECTORS22
Nominees22
Vote Required22
PROPOSAL NO. 2 ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS23
Vote Required23
PROPOSAL NO. 3 RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM24
Fees Paid to the Independent Registered Public Accounting Firm24
Auditor Independence24
Audit Committee Policy on Pre-Approval of Audit and Permissible Non-Audit Services of Independent Registered Public Accounting Firm25
Vote Required25
AUDIT COMMITTEE REPORT26
EXECUTIVE OFFICERS27
EXECUTIVE COMPENSATION29
Named Executive Officers29
Summary29
Compensation Philosophy30
“Say-on-Pay” Voting30
Compensation Determination Process30
Pay Components31
Severance and Change in Control Protections32
Other Compensation32
Additional Policies and Practices33
Summary Compensation Table34
Outstanding Equity Awards at 2025 Year-End35
Executive Employment Letter Agreements36
Change in Control and Severance Agreements37
Executive Incentive Compensation Plan38
2025 Inducement Equity Incentive Plan39
Equity Compensation Plan Information40
Compensation Recovery (Clawback)41
Insider Trading Policy42
Pay Versus Performance42
Description of Relationship Between Compensation Actually Paid and Company Total Shareholder Return (or TSR)44
Description of Relationship Between NEO Compensation Actually Paid and Net Income/(Loss)45
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT46
CERTAIN RELATIONSHIPS, RELATED PARTY AND OTHER TRANSACTIONS49
venBio Consulting Agreement49
Tallac Therapeutics Agreements49
ScalmiBio Milestone Payments50
Indemnification Agreements50
Related-Party Transaction Policy50
OTHER MATTERS51
Delinquent Section 16(a) Reports51

ALX ONCOLOGY HOLDINGS INC.

PROXY STATEMENT

FOR THE 2026 ANNUAL MEETING OF STOCKHOLDERS

To Be Held at 1:00 p.m. Pacific Time on Wednesday, June 10, 2026

This proxy statement and the enclosed form of proxy are furnished in connection with the solicitation of proxies by our board of directors for use at the 2026 annual meeting of stockholders of ALX Oncology Holdings Inc. (the Annual Meeting), and any postponements, adjournments or continuations thereof. The Annual Meeting will be held on Wednesday, June 10, 2026 at 1:00 p.m. Pacific Time virtually via a live webcast. You will be able to attend the Annual Meeting virtually by visiting www.virtualshareholdermeeting.com/ALXO2026, where you will be able to listen to the meeting live, submit questions and vote online by entering the control number on your proxy card.

ContentsView on SEC.gov

The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.