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Tenaya Therapeutics, Inc.

For the period ended May 27, 2026. Filed Apr 16, 2026.

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About this filing

What shareholders are asked to vote on at a company's meeting. It is where to find what directors and top executives are paid, and who owns the most shares.

May 27, 2026 · Filed Apr 16, 2026

Use the contents to explore the available documents and sections.

TNYA$0.36+14.0%Stored close · as of Nov 6, 2026
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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE

SECURITIES EXCHANGE ACT OF 1934

Filed by the Registrant ☒

Filed by a party other than the Registrant ☐

Check the appropriate box:

☐Preliminary Proxy Statement
☐Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2))
☒Definitive Proxy Statement
☐Definitive Additional Materials
☐Soliciting Material Pursuant to §240.14a‑12

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check all boxes that apply):

☒No fee required
☐Fee paid previously with preliminary materials
☐Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11

(650) 825-6900

April 16, 2026

Dear Fellow Stockholders:

We are pleased to invite you to attend the annual meeting of stockholders of Tenaya Therapeutics, Inc. (Tenaya or the Company), to be held on Wednesday, May 27, 2026 at 8:00 a.m. Pacific Time. The annual meeting will be conducted virtually this year via a live audio webcast and will afford all of our stockholders the same rights and opportunities to participate as would be available at an in-person meeting. You will be able to attend the annual meeting virtually by visitingwww.proxydocs.com/TNYA, where you will be able to listen to the meeting live, submit questions and vote online by entering the control number located on your proxy card.

The attached formal meeting notice and proxy statement contain details of the business to be conducted at the annual meeting.

Your vote is important. Whether or not you attend the annual meeting, it is important that your shares be represented and voted at the annual meeting. Therefore, we urge you to vote and submit your proxy promptly via the Internet, telephone or mail.

On behalf of our Board of Directors, we would like to express our appreciation for your continued support of and interest in Tenaya.

Sincerely,

Faraz Ali, M.B.A.

Chief Executive Officer

NOTICE OF ANNUAL MEETING OF stockholders

Time and Date8:00 a.m. Pacific Time on Wednesday, May 27, 2026
PlaceThe annual meeting will be conducted virtually via a live audio webcast. You will be able to attend the annual meeting virtually by visiting www.proxydocs.com/TNYA, where you will be able to listen to the meeting live, submit questions and vote online during the meeting by visiting www.proxypush.com/TNYA.
Items of Business•To elect three Class II directors to hold office until our 2029 annual meeting of stockholders and until their respective successors are elected and qualified.•To ratify the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2026.•To amend and restate the Tenaya Therapeutics, Inc. 2021 Equity Incentive Plan to, among other things, increase the number of shares of our common stock reserved for issuance by approximately 3% of our outstanding shares and remove the annual limit of 4 million shares from the “evergreen” provision.•To transact other business that may properly come before the annual meeting or any adjournments or postponements thereof.
Record DateWednesday, April 1, 2026Only stockholders of record as of Wednesday, April 1, 2026, at the close of business are entitled to notice of and to vote at the annual meeting.
Availability of Proxy MaterialsThe Notice of Internet Availability of Proxy Materials containing instructions on how to access our proxy statement, notice of annual meeting, form of proxy and our annual report, is first being sent or given on or about April 16, 2026, to all stockholders entitled to vote at the annual meeting. We are providing access to our proxy materials over the Internet under the rules adopted by the Securities and Exchange Commission (SEC). The proxy materials and our annual report can be accessed as of April 16, 2026, by visiting www.proxydocs.com/TNYA.
VotingYour vote is important. Whether or not you plan to attend the annual meeting, we urge you to submit your proxy or voting instructions via the Internet, telephone or mail as soon as possible to ensure your shares are represented. For additional instructions for each of these voting options, please refer to the proxy card. Returning your proxy card does not deprive you of your right to attend the annual meeting and to vote your shares at the annual meeting. The proxy statement explains proxy voting and the matters to be voted on in more detail.

By order of the Board of Directors,

Faraz Ali, M.B.A.Chief Executive OfficerSouth San Francisco, CaliforniaApril 16, 2026

This proxy statement is being mailed to stockholders on or about April 16, 2026.

TABLE OF CONTENTS

Page
QUESTIONS AND ANSWERS ABOUT THE PROXY MATERIALS AND OUR ANNUAL MEETING1
BOARD OF DIRECTORS AND CORPORATE GOVERNANCE9
Composition of the Board9
Class II Nominees for Director9
Continuing Directors10
Director Independence12
Board Leadership Structure13
Role of Board in Risk Oversight Process13
Board Committees13
Attendance at Board and Stockholders Meetings16
Compensation Committee Interlocks and Insider Participation16
Considerations in Evaluating Director Nominees16
Stockholders Recommendations and Nominations to our Board of Directors17
Communications with the Board of Directors17
Policy Prohibiting Hedging or Pledging of Securities18
Insider Trading Policy18
Corporate Governance Guidelines and Code of Business Conduct and Ethics18
Director Compensation18
PROPOSAL NO. 1 ELECTION OF CLASS II DIRECTORS21
Nominees21
Vote Required21
Board Recommendation21
PROPOSAL NO. 2 RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM22
Fees Paid to the Independent Registered Public Accounting Firm22
Auditor Independence22
Audit Committee Policy on Pre-Approval of Audit and Permissible Non-Audit Services of Independent Registered Public Accounting Firm22
Vote Required23
Board Recommendation23
AUDIT COMMITTEE REPORT24
PROPOSAL NO. 3 APPROVAL OF THE TENAYA THERAPEUTICS, INC. AMENDED AND RESTATED 2021 EQUITY INCENTIVE PLAN25
Material Differences Between the Current 2021 Plan and the Restated Plan25
Why Should Stockholders Vote to Approve the Restated Plan?26
Summary of the Restated Plan28
Summary of U.S. Federal Income Tax Consequences32
Number of Awards Granted to Employees, Consultants and Directors34
Vote Required34
Board Recommendation35
EXECUTIVE OFFICERS36
EXECUTIVE COMPENSATION37
Processes and Procedures for Compensation Decisions37
Summary Compensation Table37
Employment Arrangements38

-i-

Executive Change in Control and Severance Plan38
Equity Plans39
Executive Incentive Compensation Plan39
Clawback Policy40
401(k) Plan40
Policies and Practices for Granting Certain Equity Awards40
Outstanding Equity Awards at Fiscal 2025 Year-End42
Equity Compensation Plan Information43
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT44
RELATED PERSON TRANSACTIONS46
Investors’ Rights Agreement46
Stock, Pre-funded Warrant, Warrant Issuances46
Indemnification Agreements46
Policies and Procedures for Related Person Transactions47
OTHER MATTERS48
Delinquent Section 16(a) Reports48
APPENDIX A49
AMENDED AND RESTATED TENAYA THERAPEUTICS, INC. 2021 EQUITY INCENTIVE PLAN49

-ii-

PROXY STATEMENT

FOR THE 2026 ANNUAL MEETING OF STOCKHOLDERS

To be held at 8:00 a.m. Pacific Time on Wednesday, May 27, 2026

The information provided in the “question and answer” format below is for your convenience only and is merely a summary of the information contained in this proxy statement. You should read this entire proxy statement carefully.

QUESTIONS AND ANS

ContentsView on SEC.gov

The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.