Cyclerion Therapeutics, Inc.

SIGNAT URES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrants have duly caused this report to be signed on their behalf by the undersigned, thereunto duly authorized, on March 30, 2026.

CYCLERION THERAPEUTICS, INC.

By:

/s/ Regina Graul

Regina Graul

President and Chief Executive Officer

POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Regina Graul and Rhonda Chicko, jointly and severally, as his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign this Annual Report on Form 10-K of Cyclerion Therapeutics, Inc.,

and any or all amendments thereto, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises hereby ratifying and confirming all that said attorneys-in-fact and agents, or his, her or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities indicated on March 30, 2026.

Signature

Title

/s/ Regina Graul

Regina Graul

President, Chief Executive Officer (Principal Executive Officer) and Director

/s/ Rhonda Chicko

Rhonda Chicko

Chief Financial Officer (Principal Financial and Accounting Officer)

/s/ Errol De Souza

Errol De Souza

/s/ Peter Hecht

Peter Hecht

/s/ Michael Higgins

Michael Higgins

/s/ Steven Hyman

Steven Hyman

/s/ Dina Katabi

Dina Katabi

Index to Consolidated Financial Statements of Cyclerion Therapeutics, Inc.