Xilio Therapeutics, Inc.

For the period ended Dec 31, 2025. Filed Mar 23, 2026.

About this filing

A company's yearly report to the SEC, with audited financial statements. It is the fullest account a company gives of its business, its finances and the risks it sees.

FY2025 · Filed Mar 23, 2026

XLO$9.00+4.4%Stored close · as of Nov 9, 2026

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Contents

Cover page Table of Contents

PART I

Item 1. Business (no text here)

Item 1. Business

Item 1A. Risk Factors (no text here)

Item 1A. Risk Factors

Item 1B. Unresolved Staff Comments (no text here)

Item 1B. Unresolved Staff Comments

Item 1C. Cybersecurity (no text here)

Item 1C. Cybersecurity

Item 2. Properties (no text here)

Item 2. Properties

Item 3. Legal Proceedings (no text here)

Item 3. Legal Proceedings

Item 4. Mine Safety Disclosures (no text here)

Item 4. Mine Safety Disclosures

PART II

Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities (no text here)

Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities

Item 6. [Reserved] (no text here)

Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations (no text here)

Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations Overview Financial Operations Overview Results of Operations Contractual Obligations Critical Accounting Policies and Use of Estimates

Item 7A. Quantitative and Qualitative Disclosures About Market Risk (no text here)

Item 8. Financial Statements and Supplementary Data

Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure (no text here)

Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

Item 9A. Controls and Procedures (no text here)

Item 9A. Controls and Procedures

Evaluation of Disclosure Controls and Procedures Management’s Annual Report on Internal Control over Financial Reporting Changes in Internal Control over Financial Reporting

Item 9B. Other Information (no text here)

Item 9B. Other Information Item 9C. Disclosure Regarding Foreign Jurisdictions That Prevent Inspections

PART III

Item 10. Directors, Executive Officers and Corporate Governance (no text here)

Item 10. Directors, Executive Officers, and Corporate Governance

Item 11. Executive Compensation (no text here)

Item 11. Executive Compensation

Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters (no text here)

Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

Item 13. Certain Relationships and Related Transactions, and Director Independence (no text here)

Item 13. Certain Relationships and Related Transactions, and Director Independence

Item 14. Principal Accountant Fees and Services (no text here)

Item 14. Principal Accountant Fees and Services

PART IV

Item 15. Exhibits and Financial Statement Schedules (no text here)

Item 15. Exhibits and Financial Statement Schedules Indicates management contract or compensatory plan or arrangement.

Item 16. Form 10-K Summary (no text here)

Item 16. Form 10‑K Summary Xilio Therapeutics, Inc.REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM Consolidated Balance Sheets Consolidated Statements of Operations and Comprehensive Loss Consolidated Statements of Stockholders’ Equity Item 8. Consolidated Statements of Cash Flows Notes to Consolidated Financial Statements 1. Description of Business and Liquidity 2. Summary of Significant Accounting Policies 3. Fair Value Measurements 4. Property and Equipment, Net 5. Accrued Expenses Collaboration, License and Option Agreement with AbbVie License Agreement with Gilead Sciences, Inc.Clinical Trial Collaboration with F. Hoffmann-La Roche Ltd Amended and Restated Exclusive License Agreement with City of Hope CTLA-4 Monoclonal Antibody License Agreement with WuXi Biologics 7. Leases 8. Commitments and Contingencies 9. Preferred Stock and Common Stock 10. Stock-Based Compensation 11. Net Loss Per Share 12. Income Taxes 13. 401(k) Plan

Item 9B. Other Information

Director and Officer Trading Arrangements

A portion of the compensation of our directors and officers (as defined in Rule 16a-1(f) under the Exchange Act) is in the form of equity awards and, from time to time, directors and officers may engage in open-market transactions with respect to the securities acquired pursuant to such equity awards or other of our securities, including to satisfy tax withholding obligations when equity awards vest or are exercised, and for diversification or other personal reasons.

Transactions in our securities by directors and officers are required to be made in accordance with ourinsider trading policy, which requires that the transactions be in accordance with applicable U.S. federal securities laws that prohibit trading while in possession of material nonpublic information. Rule 10b5-1 under the Exchange Act provides an affirmative defense that enables directors and officers to prearrange transactions in our securities in a manner that could negate a claim of insider trading for transactions undertaken while in possession of material nonpublic information.

None of our directors or officers adopted or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement (as such terms are defined in Items 408(a) and 408(c) of Regulation S-K, respectively) during the fourth quarter of 2025.

ContentsView on SEC.gov

The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.