SPRUCE BIOSCIENCES, INC.

There areno disclosures required by this Item 9B relating to “Rule 10b5-1 trading arrangements” and “non-Rule 10b5-1 trading arrangements,” as those terms are defined in Item 408 of Regulation S-K.

Our 2026 Annual Meeting of the Stockholders, or the 2026 Annual Meeting, has been tentatively scheduled to occur on May 21, 2026. The time and location of the 2026 Annual Meeting, and the matters to be considered, will be as set forth in our definitive proxy statement to be filed on Schedule 14A with the SEC for the 2026 Annual Meeting.

The date of our 2026 Annual Meeting will have changed by more than 30 days from the anniversary of our 2025 Annual Meeting of the Stockholders. In accordance with Rule 14a-5(f) and Rule 14a-8(e) under the Exchange Act, we will consider shareholder proposals submitted pursuant to Rule 14a-8 for inclusion in our proxy materials for the 2026 Annual Meeting to have been submitted in a timely fashion if such proposals are received by us no later than March 19, 2026. Any proposal intended to be considered for inclusion in our proxy materials must comply with Rule 14a-8 of Regulation 14A of the proxy rules of the SEC. Such proposals should be delivered to 611 Gateway Boulevard, Suite 740, South San Francisco, California 94080, Attention: Corporate Secretary. The submission of a proposal does not guarantee that it will be included in our proxy materials.

In addition, in light of the foregoing and in accordance with Rule 14a-5(e)(2) and Rule 14a-5(f) under the Exchange Act, in order for shareholder proposals submitted outside of Rule 14a-8 in connection with the 2026 Annual Meeting to be considered timely for purposes of Rule 14(a)-4(c) under the Exchange Act, such proposals must be received by us no later than March 19, 2026. Such proposals should be delivered to our 611 Gateway Boulevard, Suite 740, South San Francisco, California 94080, Attention: Corporate Secretary. Proposals must comply with the procedures and include the information required by our bylaws.