Amylyx Pharmaceuticals, Inc.
For the period ended Dec 31, 2025. Filed Mar 3, 2026.
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FY2025 · Filed Mar 3, 2026
AMLX$30.91+2.3%Stored close · as of Nov 10, 2026
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Item 8. Consolidated Statements of Cash Flows
CONSOLIDATED STATEMENTS OF CASH FLOWS
(in thousands)
| Year Ended December 31, | ||
|---|---|---|
| 2025 | 2024 | |
| Cash flows used in operating activities: | ||
| Net loss | $(144,735) | $(301,743) |
| Adjustments to reconcile net loss to net cash used in operating activities: | ||
| Stock-based compensation expense | 27,645 | 33,038 |
| Depreciation expense | 525 | 904 |
| Accretion of investment discounts, net | (5,526) | (9,856) |
| Inventory impairment and loss on firm purchase commitments | — | 118,680 |
| Charge for purchase of IPR&D assets | — | 36,203 |
| Other non-cash items | (169) | 958 |
| Changes in operating assets and liabilities: | ||
| Accounts receivable, net | 359 | 39,602 |
| Inventories | — | (9,253) |
| Interest receivable | 24 | 359 |
| Prepaid expenses and other current assets | 5,960 | 1,998 |
| Operating lease right-of-use assets | 1,730 | 1,954 |
| Deposits and other assets | (1,976) | 677 |
| Accounts payable | 580 | (19,102) |
| Accrued expenses | (6,598) | (59,810) |
| Operating lease liabilities | (1,162) | (2,256) |
| Net cash used in operating activities | (123,343) | (167,647) |
| Cash flows provided by investing activities: | ||
| Purchases of property and equipment | (138) | (157) |
| Purchases of IPR&D assets, including transaction costs | — | (36,203) |
| Purchases of investments | (231,823) | (231,986) |
| Proceeds from maturities of marketable securities | 246,000 | 344,000 |
| Net cash provided by investing activities | 14,039 | 75,654 |
| Cash flows provided by financing activities: | ||
| Proceeds from financings, net of issuance costs | 256,313 | — |
| Proceeds from exercise of stock options and RSUs vesting | 4,077 | 2,132 |
| Withholding taxes paid on stock-based awards | (3,361) | (1,784) |
| Net cash provided by financing activities | 257,029 | 348 |
| Effect of exchange rate changes on cash, cash equivalents and restricted cash equivalents | 1,074 | (438) |
| Net increase (decrease) in cash, cash equivalents and restricted cash equivalents | 148,799 | (92,083) |
| Cash, cash equivalents and restricted cash equivalents, beginning of year | 78,837 | 170,920 |
| Cash, cash equivalents and restricted cash equivalents, end of year | $227,636 | $78,837 |
| Reconciliation of cash, cash equivalents and restricted cash equivalents: | ||
| Cash and cash equivalents | $226,651 | $77,391 |
| Restricted cash equivalents | 985 | 1,446 |
| Total cash, cash equivalents and restricted cash equivalents: | $227,636 | $78,837 |
| Supplemental disclosure of cash flow information: | ||
| Other assets included in accounts payable and accrued expenses | $500 | $— |
| Right-of-use assets obtained in exchange for new operating lease liabilities | $5,140 | $— |
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