BIODESIX INC

Report of Independent Regist ered Public Accounting Firm

To the Stockholders and the Board of Directors

Biodesix, Inc.:

Opinion on the Financial Statements

We have audited the accompanying balance sheets of Biodesix, Inc. (the Company) as of December 31, 2025 and 2024, the related statements of operations, stockholders’ (deficit) equity, and cash flows for the years then ended December 31, 2025, and the related notes (collectively, the financial statements). In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company as of December 31, 2025 and 2024, and the results of its operations and its cash flows for the years then ended December 31, 2025, in conformity with U.S. generally accepted accounting principles.

Basis for Opinion

These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits, we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

Critical Audit Matter

The critical audit matter communicated below is a matter arising from the current period audit of the financial statements that was communicated or required to be communicated to the audit committee and that: (1) relates to accounts or disclosures that are material to the financial statements and (2) involved our especially challenging, subjective, or complex judgments. The communication of a critical audit matter does not alter in any way our opinion on the financial statements, taken as a whole, and we are not, by communicating the critical audit matter below, providing a separate opinion on the critical audit matter or on the accounts or disclosures to which it relates.

Measurement of diagnostic tests revenue

As discussed in Notes 2 and 11 to the financial statements, the Company derives revenue from two sources: (i) diagnostic tests, providing lung diagnostic testing services for healthcare providers associated with blood-based tests and (ii) development services to biopharmaceutical, life sciences and diagnostic companies. For diagnostic tests revenue, the Company estimates the transaction price, which is the amount of consideration it expects to be entitled to receive in exchange for providing services based on its historical collection experience, using a portfolio approach by considering payment history, historical price concessions and reimbursement contracts, among other factors including variable consideration. The Company recognized revenues of $79.2 million for the year ended December 31, 2025, related to diagnostic tests revenue.

We identified the evaluation of diagnostic tests revenue as a critical audit matter. Subjective auditor judgment was required to evaluate the measurement of diagnostic tests revenue, specifically the estimation of the amount of diagnostic tests revenue expected to be collectible from payors.

The following are the primary procedures we performed to address this critical audit matter. We evaluated the design of an internal control related to the estimation of the amount of diagnostic tests revenue expected to be collected, including managements consideration of the impact of payment histories. We compared diagnostic tests revenue recorded by the Company to subsequent cash receipts. For a sample of tests, we evaluated collections of revenue to identify whether the estimation method required adjustment. This included comparing collections to certain relevant documentation, including explanation of benefits and test results. In addition, we inquired of the individuals responsible for monitoring and tracking the status of anticipated collections to understand the progress of these activities and any impact on management’s estimates.

/s/ KPMG LLP

We have served as the Company’s auditor since 2016.

Denver, Colorado

February 26, 2026