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Karyopharm Therapeutics Inc.

For the period ended Dec 31, 2025. Filed Feb 13, 2026.

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A company's yearly report to the SEC, with audited financial statements. It is the fullest account a company gives of its business, its finances and the risks it sees.

FY2025 · Filed Feb 13, 2026

KPTI$0.04-27.1%Stored close · as of Nov 9, 2026

Extracted filing text, with the paragraph anchors used by the comparison.

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Contents

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

Date: February 12, 2026KARYOPHARM THERAPEUTICS INC.
By:/s/ Richard Paulson
Richard PaulsonPresident and Chief Executive Officer and Director(Principal Executive Officer)

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

SignatureTitleDate
/s/ Richard PaulsonPresident and Chief Executive Officer and DirectorFebruary 12, 2026
Richard Paulson(Principal Executive Officer)
/s/ Lori Macomber Lori MacomberExecutive Vice President, Chief Financial Officer and TreasurerFebruary 12, 2026
(Principal Financial Officer)
/s/ Kristin AbateVice President, Chief Accounting Officer and Assistant TreasurerFebruary 12, 2026
Kristin Abate(Principal Accounting Officer)
/s/ Garen G. BohlinDirectorFebruary 12, 2026
Garen G. Bohlin
/s/ Barry E. GreeneDirectorFebruary 12, 2026
Barry E. Greene
/s/ Christy J. OligerDirectorFebruary 12, 2026
Christy J. Oliger
/s/ Deepika R. PakianathanDirectorFebruary 12, 2026
Deepika R. Pakianathan, Ph.D.
/s/ Chen SchorDirectorFebruary 12, 2026
Chen Schor
/s/ Zhen SuDirectorFebruary 12, 2026
Zhen Su, M.D.
ContentsView on SEC.gov

The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.