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Karyopharm Therapeutics Inc.

For the period ended Dec 31, 2025. Filed Feb 13, 2026.

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A company's yearly report to the SEC, with audited financial statements. It is the fullest account a company gives of its business, its finances and the risks it sees.

FY2025 · Filed Feb 13, 2026

KPTI$0.02-56.5%Stored close · as of Nov 10, 2026

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Contents

Item 15. Exhibits and Financial Statement Schedules

(a)(1) Financial Statements

The financial statements listed below are filed as a part of this Annual Report on Form 10-K.

Pagenumber
Report of Independent Registered Public Accounting Firm (PCAOB ID 42)124
Consolidated Balance Sheets as of December 31, 2025 and 2024127
Consolidated Statements of Operations for the years ended December 31, 2025, 2024 and 2023128
Consolidated Statements of Comprehensive Loss for the years ended December 31, 2025, 2024 and 2023129
Consolidated Statements of Stockholders’ Deficit for the years ended December 31, 2025, 2024 and 2023130
Consolidated Statements of Cash Flows for the years ended December 31, 2025, 2024 and 2023131
Notes to Consolidated Financial Statements132

(a)(2) Financial Statement Schedules

All financial schedules have been omitted because the required information is either presented in the consolidated financial statements or the notes thereto or is not applicable or required.

(a)(3) Exhibits

The exhibits required by Item 601 of Regulation S-K and Item 15(b) of this Annual Report on Form 10-K are listed in the Exhibit Index immediately preceding the signature page of this Annual Report on Form 10-K and are incorporated herein.

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The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.