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Predictive Oncology Inc.

For the period ended Nov 25, 2025. Filed Oct 27, 2025.

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About this filing

What shareholders are asked to vote on at a company's meeting. It is where to find what directors and top executives are paid, and who owns the most shares.

Nov 25, 2025 · Filed Oct 27, 2025

AGPU$6.73+11.2%Stored close · as of Nov 6, 2026
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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No. )

Filed by the Registrant ☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:

☐Preliminary Proxy Statement
☐Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
☒Definitive Proxy Statement
☐Definitive Additional Materials
☐Soliciting Material under §240.14a-12

Predictive Oncology Inc.

(Name of registrant as specified in its charter)

(Name of person(s) filing proxy statement, if other than the registrant)

Payment of Filing Fee (Check all boxes that apply):

☒No fee required
☐Fee paid previously with preliminary materials
☐Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11

91 43rd Street, Suite 110

Pittsburgh, Pennsylvania 15201

Telephone: (412) 432-1500

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To Be Held on November 25, 2025

Dear Stockholder:

You are cordially invited to attend the Annual Meeting of Stockholders (the “Annual Meeting”) of Predictive Oncology Inc. (the “Company”) on November 25, 2025, at 12:00 PM (Eastern Time) at the offices of DLA Piper LLP (US) at 1001 Liberty Avenue, Suite 500, Pittsburgh, Pennsylvania, 15222 for the following purposes:

1.To elect two Class I directors to hold office until the 2028 Annual Meeting of Stockholders;
2.To ratify the appointment of KPMG LLP (“KPMG”) as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2025 (the “Auditor Proposal”);
3.To approve an amendment to the Company’s 2024 Equity Incentive Plan (the “Plan Amendment Proposal”);
4.To approve, in accordance with Nasdaq Listing Rule 5635(a), the issuance of 14,903,393 shares of our common stock upon the exercise of pre-funded warrants to purchase 14,903,393 shares of common stock (the “Issuance Proposal”);
5.To vote on a non-binding advisory resolution to approve compensation of the Company’s executive officers as disclosed in the proxy statement accompanying this Notice; and
6.To transact any other business as may properly come before the Annual Meeting or any adjournments thereof.

These items of business are more fully described in the proxy statement accompanying this Notice.

The record date for the Annual Meeting is October 24, 2025. Only stockholders of record at the close of business on that date are entitled to vote at the meeting or any adjournment thereof, or by proxy.

By Order of the Board of Directors,

/s/ Raymond Vennare

Raymond Vennare

Chief Executive Officer

Pittsburgh, Pennsylvania

October 27, 2025

You are cordially invited to attend the meeting in person. Whether or not you expect to attend the meeting, please vote your shares. You may vote your proxy over the Internet or by completing and returning the proxy card mailed to you. Voting instructions are printed on your proxy card and included in the proxy statement. Any stockholder attending the meeting may vote in person, even if you have previously submitted your vote. Please note, however, that if your shares are held of record by a broker, bank or other nominee and you wish to vote at the meeting, you must obtain a legal proxy issued in your name from that record holder.

IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS FOR THE

STOCKHOLDER MEETING TO BE HELD ON NOVEMBER 25, 2025:

The Notice of Annual Meeting of Stockholders, the Proxy Statement and form of proxy card for the Annual Meeting are available at https://annualgeneralmeetings.com/poai/2025/.

TABLE OF CONTENTS

QUESTIONS AND ANSWERS ABOUT THIS PROXY MATERIAL AND VOTING1
PROPOSAL NO. 1: ELECTION OF DIRECTORS6
INFORMATION REGARDING THE BOARD OF DIRECTORS AND CORPORATE GOVERNANCE8
RELATED PARTY TRANSACTIONS12
EQUITY COMPENSATION PLAN INFORMATION13
EXECUTIVE COMPENSATION14
DIRECTOR COMPENSATION17
PROPOSAL NO. 2: RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS22
PROPOSAL NO. 3: APPROVAL OF AN AMENDMENT TO THE 2024 EQUITY INCENTIVE PLAN24
PROPOSAL NO. 4: APPROVAL OF THE ISSUANCE OF OUR SHARES OF OUR COMMON STOCK UPON THE EXERCISE OF PRE- FUNDED WARRANTS30
PROPOSAL NO. 5: “SAY-ON-PAY” VOTE31
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT32
OTHER MATTERS33

91 43rd Street, Suite 110

Pittsburgh, Pennsylvania 15201

Telephone: (412) 432-1500

PROXY STATEMENT

FOR THE ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD ON NOVEMBER 25, 2025

**QUESTIONS AND ANSWERS

ContentsView on SEC.gov

The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.