Nurix Therapeutics, Inc.

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

(Rule 14a-101)

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NURIX THERAPEUTICS, INC.

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LETTER FROM OUR CEO

Dear fellow stockholders,

As we reflect on 2025 and look ahead to 2026 and beyond, Nurix enters its next chapter with a pivotal development program in chronic lymphocytic leukemia (CLL) underway. In addition, we are expanding opportunities in inflammation and immunology (I&I) and deepening our partnered pipeline. Our focus remains clear: to establish degrader-based medicines at the forefront of patient care in oncology and autoimmune disease.

Tremendous Progress in 2025: From Proof of Concept to Pivotal Trials

2025 marked a year of strategic transition for Nurix as bexobrutideg, our lead Bruton’s tyrosine kinase (BTK) degrader, advanced from clinical proof of concept into registrational development in relapsed/refractory chronic lymphocytic leukemia (CLL), the most common leukemia in adults. At the 67th American Society of Hematology (ASH) Annual Meeting, we presented maturing Phase 1a/1b data in heavily pretreated CLL patients that underscore bexobrutideg’s potential best-in-class profile.

In the Phase 1a cohort that consisted of patients who had received many prior lines of treatment, bexobrutideg achieved a remarkable objective response rate (ORR) of 83.0%, including two complete responses, with a median progression-free survival (PFS) of 22.1 months and a median duration of response of 20.1 months across all doses tested. Data from the randomized Phase 1b cohort comparing 200 mg and 600 mg once-daily dosing demonstrated higher response rates and a favorable trend toward longer PFS at the 600 mg dose. These results supported the 600 mg dose as the recommended Phase 2 dose in accordance with FDA’s Project Optimus. Importantly, bexobrutideg was well tolerated, demonstrating a consistent safety profile across dose levels, with no dose-limiting toxicities, no systemic fungal infections, and no Grade 4 infections.

We also reported encouraging Phase 1 data in Waldenström macroglobulinemia (WM), a type of non-Hodgkin lymphoma, achieving a 75.0% ORR with a median follow-up of 8.1 months. Notably, neither median duration of response nor PFS had been reached, indicating that patients continue to benefit from therapy over time. Collectively, these results position bexobrutideg as a potentially transformative once-daily, oral therapy for patients with B-cell malignancies.

Beyond bexobrutideg, we continued to advance our broader oncology pipeline, reflecting Nurix’s ability to apply its degrader expertise across multiple programs. Zelebrudomide, our dual BTK and cereblon neosubstrate degrader, progressed through dose escalation with the new chirally controlled drug form. NX-1607, our oral CBL-B inhibitor, generated additional monotherapy signals of efficacy with a disease control rate of 49.3% across doses and tumor types as well as supportive translational data in solid tumors, demonstrating dose-dependent target engagement and peripheral immune activation.

DAYBreak™ and the Path to Registration

The DAYBreak-201 Phase 2 study in relapsed/refractory CLL is designed as a pivotal trial to support accelerated approval in the United States. It is enrolling adult patients who have progressed after all approved agents, including a covalent BTK inhibitor, a BCL-2 inhibitor, and a non-covalent BTK inhibitor. These patients currently have few meaningful treatment options remaining.

We also announced plans for DAYBreak-306, a Phase 3 trial that will test bexobrutideg head-to-head against the latest approved BTK non-covalent inhibitor, pirtobrutinib. The trial is designed to not only enable full approval of bexobrutideg in the United States and other major markets, but also to generate practice-changing data that compares the removal of cancer-driving proteins versus merely inhibiting its enzymatic function.

STAT6 and IRAK4: Building a Differentiated I&I Portfolio

STAT6 is a key transcription factor regulating Type 2 inflammation. Our collaboration with Sanofi is focused on targeted degradation of STAT6 as an approach to modulating IL-4/IL-13–driven pathways compared with antibody or inhibitor strategies. In 2025, Sanofi exercised its option to extend its license for our STAT6 program, including on a development candidate, NX-3911, which currently is in investigational new drug (IND) enabling studies.

IRAK4 is a key kinase that regulates immune cell activity. In 2025, GS-6791 demonstrated potent and sustained IRAK4 degradation, robust inhibition of IL-1 and IL-36 signaling, and meaningful efficacy in an animal model of atopic dermatitis. Gilead and Nurix presented this preclinical data at the 2025 European Academy of Dermatology and Venereology Congress. Also in 2025, GS-6791 began a comprehensive, first-in-human Phase 1 study in healthy volunteers.

Financial Strength and Operational Discipline

We ended fiscal 2025 with $592.9 million in cash, cash equivalents, and marketable securities. In October 2025, we completed a $250.0 million underwritten registered offering with participation from leading healthcare-focused institutional investors, significantly strengthening our balance sheet and enabling accelerated execution across pivotal clinical programs and pipeline expansion.

Throughout 2025, our collaborations with Gilead, Sanofi, and Pfizer continued to validate the breadth and scalability of our DEL-AI™ platform while providing meaningful nondilutive capital. In 2025, we recognized $84.0 million in revenue from these partners and remain eligible for up to $6.1 billion in future fees and milestones, plus royalties on product sales. In oncology, our Degrader Antibody Conjugate (DAC) collaboration with Pfizer achieved multiple preclinical milestones that demonstrated the feasibility of DACs as a next-generation antibody-drug conjugate modality. In all our collaborations, we maintain highly valuable option rights to join our partners in co-development and co-commercialization in the United States, rights that are triggered after clinical data is obtained from trials funded and managed by our partners. Such optionality provides us with the ability to selectively and cost-effectively develop our product pipeline in alignment with established leaders in the fields of oncology and I&I.

Looking Ahead to 2026: Advancing to Phase 3 in Oncology and Expanding into I&I

The central theme for 2026 is advancing bexobrutideg to Phase 3 while also broadening the bexobrutideg clinical program to include selected I&I indications. BTK sits at a critical intersection of B-cell receptor, toll-like receptor, and Fc-receptor signaling, making it a compelling target in antibody-mediated autoimmune and inflammatory diseases. While existing BTK inhibitors validate aspects of this biology, they address only the kinase function of BTK and may be limited by off-target effects.

Bexobrutideg is designed to catalytically degrade BTK, eliminating both its kinase and scaffolding functions and enabling deeper and more durable pathway suppression at low, free plasma concentrations. We believe this profile may offer a more effective and safe therapeutic option for chronic autoimmune diseases where sustained control of pathogenic B-cell and myeloid signaling must be balanced with long-term tolerability.

2026 Catalysts and Strategic Priorities

As we enter 2026, our focus centers on four major priorities:

Closing Thoughts

Nurix was founded on science that demonstrated the potential to selectively alter protein levels within the cell. After over a decade of applying rigorous scientific principles of drug discovery, we believe we are approaching an inflection point in our efforts to develop innovative, targeted protein degradation drugs to treat serious disease. We have a deep appreciation for all who have supported these efforts: the patients and families who participate in our trials, the investigators and study staff who partner with us, our corporate collaborators, our employees, and our stockholders. We expect 2026 will be a significant year for Nurix as we progress our clinical trials with the ultimate goal of delivering new therapies for patients in need. We look forward to sharing our progress as these therapies advance toward patients.

Sincerely,

Arthur T. Sands, M.D., Ph.D.

President & Chief Executive Officer

Nurix Therapeutics, Inc.

Brisbane, California

March 27, 2026

FORWARD LOOKING STATEMENTS

The CEO letter above and the proxy statement below contain statements that relate to future events and expectations and as such constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statement may be identified by words such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,” “outlook,” “plan,” “predict,” “should,” “will,” and similar expressions and their variants. All statements that reflect Nurix’s expectations, assumptions or projections about the future are forward-looking statements, including, without limitation, statements regarding: Nurix’s future plans, prospects and strategies; Nurix’s plans and expectations with respect to its current and prospective drug candidates; the tolerability, safety profile, therapeutic potential and other advantages of Nurix’s drug candidates; the planned timing and conduct of Nurix’s clinical trials; the planned timing for the provision of updates and findings from Nurix’s clinical trials; the potential benefits of and Nurix’s expectations with respect to its strategic collaborations; and the potential benefits and advantages of Nurix’s scientific approach, DEL-AI platform and degrader antibody conjugates. Forward-looking statements reflect Nurix’s current beliefs, expectations, and assumptions. Although Nurix believes the expectations and assumptions reflected in such forward-looking statements are reasonable, Nurix can give no assurance that they will prove to be correct. Forward-looking statements are not guarantees of future performance and are subject to risks, uncertainties and changes in circumstances that are difficult to predict, which could cause Nurix’s actual activities and results to differ materially from those expressed in any forward-looking statement. Such risks and uncertainties include, but are not limited to: (i) whether Nurix will be able to advance its drug candidates, obtain regulatory approval of and ultimately commercialize its drug candidates; (ii) uncertainties related to the timing and results of preclinical studies and clinical trials; (iii) whether Nurix will be able to fund development activities and achieve development goals; (iv) uncertainties related to the timing and receipt of payments from Nurix’s collaboration partners, including milestone payments and royalties on future product sales; (v) the impact of global business, political and macroeconomic conditions, cybersecurity events, instability in the banking system, and global events, including regional conflicts around the world, on Nurix’s business, clinical trials, financial condition, liquidity and results of operations; (vi) whether Nurix will be able to protect intellectual property and (vii) other risks and uncertainties described under the heading “Risk Factors” in Nurix’s Annual Report on Form 10-K for the year ended November 30, 2025, and other Securities and Exchange Commission filings. Accordingly, readers are cautioned not to place undue reliance on these forward-looking statements. The statements in the CEO letter and proxy statement speak only as of the date of the CEO letter and proxy statement, even if subsequently made available by Nurix on its website or otherwise. Nurix disclaims any intention or obligation to update publicly any forward-looking statements, whether in response to new information, future events, or otherwise, except as required by applicable law.

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To Be Held May 15, 2026

To Our Stockholders:

NOTICE IS HEREBY GIVEN that the 2026 Annual Meeting of Stockholders (Annual Meeting) of Nurix Therapeutics, Inc. (Nurix) is scheduled to be held on Friday, May 15, 2026, at 9:00 a.m. (Pacific Time). The meeting will be held as a virtual meeting only, via live audio webcast. You will not be able to attend the meeting in person. We believe that hosting a “virtual meeting” will enable greater stockholder attendance and participation from any location around the world.

You will be able to participate in and vote during the meeting by joining the live webcast atwww.virtualshareholdermeeting.com/NRIX2026 on Friday, May 15, 2026, at 9:00 a.m. (Pacific Time). It is important that you retain a copy of the control number found on your proxy card or voting instruction form, as such number will be required in order for stockholders to gain access to the virtual meeting.

We are holding the meeting for the following purposes, which are more fully described in the accompanying proxy statement:

In addition, stockholders may be asked to consider and vote upon such other business as may properly come before the meeting or any adjournment or postponement thereof.

Only stockholders of record at the close of business on March 20, 2026, are entitled to receive notice of, and to vote at, the Annual Meeting and any adjournments thereof. On or about March 27, 2026, we expect to mail to stockholders a Notice of Internet Availability of Proxy Materials (the Notice of Internet Availability) containing instructions on how to access our proxy statement for the Annual Meeting and our Annual Report on Form 10-K for the fiscal year ended November 30, 2025 (Annual Report). The Notice of Internet Availability also provides instructions on how to vote through the internet or by telephone and includes instructions on how to receive paper copies of the proxy materials by mail, if desired.

For 10 days prior to the meeting, a complete list of the stockholders entitled to vote at the Annual Meeting will be available upon request by any stockholder for any purpose relating to the meeting. Stockholders can request the list of stockholders through our investor relations website atir.nurixtx.com/contact-ir.

Your vote as a Nurix stockholder is very important. Each share of common stock that you own represents one vote.

For questions regarding your stock ownership, you may contact us through our website atir.nurixtx.com/contact-ir or, if you are a registered holder, via our transfer agent, Equiniti Trust Company, LLC, by email through their website athttps://equiniti.com/us/ast-access or by phone at (800) 937-5449. Whether or not you expect to attend the virtual Annual Meeting, we encourage you to read the proxy statement and vote through the internet or by telephone, or to request, sign and return your proxy card as soon as possible, so that your shares may be represented at the Annual Meeting. For specific instructions on how to vote your shares, please refer to the section titled “General Proxy Information” in the proxy statement. Information on or accessible through our website is not incorporated by reference in the proxy statement.

By Order of the Board of Directors,

Arthur T. Sands, M.D., Ph.D.

President and Chief Executive Officer

Brisbane, California

Important Notice Regarding the Availability of Proxy Materials for the virtual Annual Meeting of Stockholders to be held on May 15, 2026: the Proxy Statement and our Annual Report are available athttps://www.proxyvote.com. You will need the control number included on your proxy card or voting instruction form or included in the email to you if you received the proxy materials by e-mail, as such number will be required in order for stockholders to gain access to the virtual meeting.

PROXY STATEMENT FOR 2026 ANNUAL MEETING OF STOCKHOLDERS

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