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Immunome Inc.

For the period ended Jun 10, 2025. Filed Apr 24, 2025.

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What shareholders are asked to vote on at a company's meeting. It is where to find what directors and top executives are paid, and who owns the most shares.

Jun 10, 2025 · Filed Apr 24, 2025

IMNM$18.71+4.5%Stored close · as of Nov 6, 2026
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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of

the Securities Exchange Act of 1934 (Amendment No. )

Filed by the Registrant ☒

Filed by a party other than the Registrant ☐

Check the appropriate box:
☐Preliminary Proxy Statement
☐Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
☒Definitive Proxy Statement
☐Definitive Additional Materials
☐Soliciting Material under § 240.14a-12

Immunome, Inc.

(Name of Registrant as Specified in Its Charter)

(Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check all boxes that apply):

☒No fee required
☐Fee paid previously with preliminary materials
☐Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11

April 24, 2025

Dear Stockholder:

We are pleased to invite you to attend Immunome, Inc.’s 2025 Annual Meeting of Stockholders which will be held at 11:30 a.m. Eastern Time, on Tuesday, June 10, 2025. The annual meeting will be held entirely online via a live audio webcast. We believe that hosting the Annual Meeting virtually will enable greater stockholder attendance and participation and improves our ability to communicate more effectively with our stockholders. The Annual Meeting can be accessed via the Internet at: www.virtualshareholdermeeting.com/IMNM2025.

Details regarding the business to be conducted at the Annual Meeting are more fully described in the accompanying Notice of 2025 Annual Meeting of Stockholders and 2025 Annual Meeting Proxy Statement. Other than the proposals described in the Proxy Statement, the Board of Directors of Immunome, Inc. is not aware of any other matters to be presented for a vote at the Annual Meeting. Under U.S. Securities and Exchange Commission rules that allow companies to furnish proxy materials over the Internet, we have elected to deliver our proxy materials to the majority of our stockholders over the Internet. This delivery process allows us to provide stockholders with the information they need, while at the same time conserving natural resources and lowering the cost of delivery.

Your vote is important. Whether or not you plan to virtually attend the Annual Meeting, we hope you will vote as soon as possible. Information about voting methods is set forth in the accompanying Notice and Proxy Statement.

If you have any questions with respect to voting, please call our Corporate Secretary at 425-939-7410.

Sincerely,

/s/ Clay B. Siegall

Clay B. Siegall, Ph.D.

Chairman of the Board, President and Chief Executive Officer

18702 N. Creek Parkway, Suite 100

Bothell, Washington 98011

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To Be Held On June 10, 2025

Dear Stockholder:

You are cordially invited to attend the Annual Meeting of Stockholders (the “Annual Meeting”) of Immunome, Inc., a Delaware corporation. The Annual Meeting will be held on Tuesday, June 10, 2025, at 11:30 a.m. Eastern Time. The Annual Meeting will be a virtual meeting of stockholders, which will be conducted only via a live audio webcast. You will be able to attend the Annual Meeting, submit any questions and vote online during the meeting by visitingwww.virtualshareholdermeeting.com/IMNM2025. The Annual Meeting will be held for the following purposes:

1.To elect the two nominees named in this Proxy Statement to serve as Class II directors, to hold office until the 2028 Annual Meeting of Stockholders and such time as their successors are duly elected and qualified, or until their earlier death, resignation or removal.
2.To ratify the appointment by the Audit Committee of the Board of Ernst & Young LLP as Immunome, Inc.’s independent registered public accounting firm for the fiscal year ending December 31, 2025.
3.To conduct any other business properly brought before the Annual Meeting.

These items of business are more fully described in the Proxy Statement accompanying this Notice.

The Annual Meeting will be held virtually through a live audio webcast. Stockholders of record at the close of business on April 21, 2025 and their proxy holders will be able to attend the Annual Meeting, submit questions and vote during the live audio webcast by visitingwww.virtualshareholdermeeting.com/IMNM2025 and entering the 16-digit Control Number included in your Notice of Internet Availability or in the instructions that you received via email. Please refer to the additional logistical details and recommendations in the accompanying proxy statement. You may log-in beginning at 11:15 a.m. Eastern Time, on June 10, 2025.

Only stockholders of record at the close of business on April 21, 2025 and their proxy holders may vote at the Annual Meeting or any adjournment thereof.

Important Notice Regarding the Availability of Proxy Materials for the Stockholders’ Meeting to Be Held

On Tuesday, June 10, 2025 at 11:30 a.m. Eastern Time at

www.virtualshareholdermeeting.com/IMNM2025.

The proxy statement and annual report to stockholders are available at

https://investors.immunome.com/sec-filings/.

By Order of the Board of Directors

/s/ Clay B. Siegall

Clay B. Siegall, Ph.D.

Chairman of the Board, President and Chief Executive Officer

Bothell, WA

You are cordially invited to attend the Annual Meeting online. Whether or not you expect to attend the meeting, please vote over the telephone or the Internet as instructed in these materials, or, if you receive a paper proxy card by mail, by completing and returning the proxy card mailed to you, as promptly as possible in order to ensure your representation at the meeting. Even if you have voted by proxy, you may

still vote online if you attend the meeting.

IMMUNOME, INC.

18702 N. Creek Parkway, Suite 100

Bothell, WA 98011

PROXY STATEMENT

FOR THE 2025 ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD ON JUNE 10, 2025

MEETING AGENDA

ProposalsVoting StandardBoard Recommendation
Election of director nominees named in this Proxy StatementPlurality of the votes castFOR each of the Board’s nominees for director
Ratification of the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2025Majority of the votes castFOR ratification of the appointment
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The text of this filing, as the company filed it with the SEC, without its images or exhibits. This is not investment advice.