ILLUMINA, INC.

As of March 29, 2026, we had $1,089 million in cash and cash equivalents, of which $554 million was held by foreign subsidiaries. Cash and cash equivalents decreased by $329 million from December 28, 2025 due to factors described in the “Cash Flow Summary” below. Our primary source of liquidity, other than our holdings of cash, cash equivalents, and investments, has been cash flows from operations and, from time to time, issuances of debt. Our ability to generate cash from operations, supplemented with the issuance of debt and/or liquidation of our short-term investments, provides us with the financial flexibility we need to meet operating, investing, and financing needs. In Q1 2026, we received proceeds from sales of our short-term investment in GRAIL of $104 million. As of March 29, 2026, we had $66 million remaining in short-term investments, comprised of marketable equity securities.

On January 30, 2026, we acquired SomaLogic for a total purchase price of $460 million, including cash of $382 million and contingent consideration with an estimated fair value of $81 million, offset by $3 million for settlement of a preexisting relationship. Under the contingent consideration arrangements, Standard BioTools is eligible to receive up to $75 million in milestone payments, comprised of up to $25 million based on 2025 performance and up to $50 million based on 2026 performance, due upon the achievement of specified revenue targets. Standard BioTools is also entitled to receive a 2% royalty on revenues generated from sales of SOMAmer-based NGS library preparation kits, paid quarterly for 10 years through January 2036. As of March 29, 2026, the aggregate fair value of our contingent consideration liabilities was $84 million, of which $66 million was included in accrued liabilities. In April 2026, we paid $25 million for the milestone payment earned for the 2025 performance period.

In November 2025, we issued $500 million aggregate principal amount of 2030 Term Notes, which mature on December 12, 2030 and accrue interest at a rate of 4.750% per annum, payable semi-annually in June and December of each year. In September 2024, we issued $500 million aggregate principal amount of 2026 Term Notes, which mature on September 9, 2026 and accrue interest at a rate of 4.650% per annum, payable semi-annually in March and September of each year. In December 2022, we issued $500 million aggregate principal amount of 2027 Term Notes, which mature on December 13, 2027 and accrue interest at a rate of 5.750% per annum, payable semi-annually in June and December of each year. In March 2021, we issued $500 million aggregate principal amount of 2031 Term Notes, which mature on March 23, 2031 and accrue interest at a rate of 2.550% per annum, payable semi-annually in March and September of each year. We may redeem for cash all or any portion of the 2026, 2027, 2030, or 2031 Term Notes, at our option, at any time prior to maturity.

In January 2023, we entered into the Revolving Credit Agreement, which provides us with a $750 million senior unsecured five year revolving credit facility, including a $40 million sublimit for swingline borrowings and a $50 million sublimit for letters of credit. The credit facility matures, and all amounts outstanding become due and payable in full, on January 4, 2028, subject to two one-year extensions at our option and consent of the extending lenders and certain other conditions. As of March 29, 2026, there were no outstanding borrowings.

As of March 29, 2026, the fair value of our contingent consideration liability related to GRAIL was $35 million, of which $33 million was included in other long-term liabilities. The contingent value rights entitle the holders to receive future cash payments on a quarterly basis (Covered Revenue Payments) representing a pro rata portion of certain GRAIL-related revenues (Covered Revenues) each year through August 2033. This reflects a 2.5% payment right to the first $1 billion of revenue each year for 12 years. Revenue above $1 billion each year is subject to a 9% contingent payment right during this same period. In Q1 2026, we paid $410,000 in aggregate Covered Revenue Payments related to aggregate Covered Revenues for the period Q4 2025 of $44 million.

In August 2024, our Board of Directors authorized the 2024 Repurchase Program, which canceled and superseded all prior and available repurchase authorizations, to repurchase up to $1.5 billion of our outstanding common stock. The repurchases may be completed through open market purchases, pursuant to Rule 10b5-1 or Rule 10b-18, or through an accelerated share repurchase program. Authorizations to repurchase up to approximately $400 million of our outstanding common stock remained available as of March 29, 2026. Subsequent to March 29, 2026 and through May 1, 2026, we repurchased an additional approximate 720,000 shares of our common stock for $90 million under the 2024 Repurchase Program. As of May 1, 2026, authorizations to repurchase up to approximately $310 million of our outstanding common stock remained available. On April 28, 2026, our Board of Directors authorized a new 2026 Repurchase Program to repurchase up to $1.5 billion of our outstanding common stock. The 2026 Repurchase Program is in addition to the $1.5 billion previously authorized under the 2024 Repurchase Program. We intend to continue to repurchase incremental shares over the course of 2026.

We had $3 million, $25 million, and $21 million, respectively, remaining in our capital commitments to three investment funds as of March 29, 2026 that are callable through December 2027, July 2029, and December 2034, respectively.

We anticipate that our current cash, cash equivalents, and short-term investments, together with cash provided by operating activities and available borrowing capacity under the Revolving Credit Facility, are sufficient to fund our near-term capital and operating needs for at least the next 12 months. Operating needs include the planned costs to operate our business, including amounts required to fund working capital and capital expenditures. Our primary short-term needs for capital, which are subject to change, may include:

•support of commercialization efforts related to our current and future products;

•acquisitions of equipment and other fixed assets for use in our current and future manufacturing and research and development facilities;

•the continued advancement of research and development efforts;

•potential strategic acquisitions and investments;

•repayment of debt obligations;

•repurchases of our outstanding common stock; and

•the evolving needs of our facilities, including costs of leasing and building out facilities.

We expect that our revenue and results of operations, as well as the status of each of our new product development programs, will significantly impact our cash management decisions. Our future capital requirements and the adequacy of our available funds will depend on many factors, including:

•our ability to successfully commercialize and further develop our technologies and create innovative products in our markets;

•scientific progress in our research and development programs and the magnitude of those programs;

•competing technological and market developments; and

•the need to enter into collaborations with other companies or acquire other companies or technologies to enhance or complement our product and service offerings.

Cash Flow Summary

Operating Activities

Net cash provided by operating activities of $289 million in Q1 2026 consisted of net income of $134 million, plus net adjustments of $156 million, less net changes in operating assets and liabilities of $1 million. The primary adjustments to net income include depreciation and amortization expense of $69 million, share-based compensation expense of $60 million, and a net loss on strategic investments of $38 million, offset by change in fair value of contingent consideration of $16 million. Cash flow impact from changes in operating assets and liabilities were primarily driven by decreases in accounts receivable and accrued liabilities and an increase in other assets.

Investing Activities

Net cash used in investing activities was $366 million in Q1 2026. We paid $415 million for acquisitions and intangible assets, net of cash acquired, and invested $38 million in capital expenditures, primarily associated with investments in facilities. This was offset by proceeds received for net sales of strategic investments of $87 million, primarily related to sales of our short-term investment in GRAIL.

Financing Activities

Net cash used in financing activities was $251 million in Q1 2026. We used $242 million to repurchase our common stock and $33 million to pay taxes related to net share settlement of equity awards. We received proceeds from the sale of shares under our employee stock purchase plan of $24 million.