Cryoport, Inc.

Insider Trading Arrangements and Policies

On May 11, 2026, Mr. Jerrell Shelton, a member of our Board of Directors and our Chairman, President, and Chief Executive Officer, entered into a trading plan, which is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). Mr. Shelton’s plan covers the potential sale of up to 500,000 shares of our common stock that were previously acquired from the exercise of stock options or settlement of restricted stock units. Transactions under Mr. Shelton’s plan are based upon pre-established dates and stock

price thresholds and will only occur upon the expiration of the applicable mandatory cooling-off period. Mr. Shelton’s plan will terminateon the earlier of March 12, 2027 or the date all shares subject to the plan have been sold.

On May 27, 2026, Mr. Daniel Hancock, amember of our Board of Directors, entered into a trading plan, which is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). Mr. Hancock’s plan covers the potential sale of up to 74,379 shares of our common stock to be acquired upon the exercise of stock options. Transactions under Mr. Hancock’s plan are based upon pre-established dates and stock price thresholds and will only occur upon the expiration of the applicable mandatory cooling-off period. Mr. Hancock’s plan will terminateon the earlier of July 30, 2027 or the date all shares subject to the plan have been sold.

No other director or officer (as defined in Exchange Act Rule 16a-1(f)) adopted or terminated a “Rule 10b5–1 trading arrangement” or a “non-Rule 10b5–1 trading arrangement,” each as defined in Item 408 of Regulation S-K of the Securities Act of 1933, as amended, during the three months ended June 30, 2026.